Results 101 to 110 of about 4,775 (199)

TRPV2

Transient potential receptor vanilloid 2 (TRPV2) is widely expressed through the nervous system and specifically found in neuronal subpopulations and some glial cells. TRPV2 is known to be sensitized by methionine oxidation, which results from inflammation.
Enrich-Bengoa, Jennifer||, Manich, Gemma||, Valente, Tony||, Sanchez-Molina, Paula||, Almolda Ardid, Beatriz||, Solà, Carme||, Saura, Josep||, González, Berta||, Castellano López, Bernardo||, Peralvarez-Marin, Alex||   +9 more
openaire   +1 more source

Functional and structural insights into activation of TRPV2 by weak acids

The EMBO Journal
Transient receptor potential (TRP) ion channels are involved in the surveillance or regulation of the acid-base balance. Here, we demonstrate that weak carbonic acids, including acetic acid, lactic acid, and CO2 activate and sensitize TRPV2 through a ...
Ferdinand M Haug, Ruth A Pumroy, Akshay Sridhar, Sebastian Pantke, Florian Dimek, Tabea C Fricke, Axel Hage, Christine Herzog, Frank G Echtermeyer, Jeanne de la Roche, Adrian Koh, Abhay Kotecha, Rebecca J Howard, Erik Lindahl, Vera Moiseenkova-Bell, Andreas Leffler   +15 more
doaj   +1 more source

Cobalt ions sensitize TRPV2 and TRPV4 channels in synovial fibroblasts, leading to cytokine secretion

Frontiers in Materials
Cobalt-chromium alloys are widely used in orthopedic implants due to their excellent toughness, wear resistance, and biocompatibility. However, cobalt ions released as consequence of corrosion or wear, trigger cytokine secretion and promote inflammation ...
Katharina Held, Katharina Held, Katharina Held, Sara Koobor, Sara Koobor, Jacob Nieckarz, Jacob Nieckarz, Rouhollah Mousavizadeh, Felipe Simon, Felipe Simon, Michael E. Cox, Michael E. Cox, Joris Vriens, Joris Vriens, Felipe Eltit   +14 more
doaj   +1 more source

TRPV2 is highly expressed on the surface of peri-infarct macrophages - a flow cytometry analysis.

, 2014
(A) Representative captures of cardiac cells dually expressing CD11B/C and TRPV2 at different time points post MI. Q2-2 upper right quadrates represent the cells which stained positive with both CD11B/C and TRPV2 (TRPV2 expressing monocytes/macrophages).
Pavel Goryainov (618055), Natalie Landa (618056), Michal Entin-Meer (618054), Gad Keren (376640), Iris Barshack (221117), Jonathan Semo (618057), Camila Avivi (221101), Ran Levy (196173)   +7 more
core   +1 more source

Embryo thermal manipulation enhances mitochondrial function in the skeletal muscle of heat-stressed broilers by regulating transient receptor potential V2 expression

Poultry Science
: Heat stress induces mitochondrial dysfunction, thereby impeding skeletal muscle development and significantly impacting the economic efficiency of poultry production.
Sheng Li, Xiaoqing Li, Kai Wang, Le Liu, Ketian Chen, Wenhan Shan, Luyao Liu, Mohamed Kahiel, Chunmei Li   +8 more
doaj   +1 more source

Sitagliptin eye drops prevent the impairment of retinal neurovascular unit in the new Trpv2 +/− rat model

Journal of Neuroinflammation
Impaired function of the retinal neurovascular unit (NVU) is an early event in diabetic retinopathy (DR). It has been previously shown that topical delivery of the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin can protect against diabetes-mediated
Hugo Ramos, Josy Augustine, Burak M. Karan, Cristina Hernández, Alan W. Stitt, Tim M. Curtis, Rafael Simó   +6 more
doaj   +1 more source

Peripheral inflammation induces up-regulation of TRPV2 expression in rat DRG

, 2005
The transient receptor potential vanilloid subfamily member 2 (TRPV2) is a cation channel activated by temperatures above 52 degrees C. To analyze the contribution of TRPV2 to the development of inflammation-induced hyperalgesia, the expression of TRPV2 ...
Tanaka, M., Amaya, F., Shimosato, G., Decosterd, I., Ueda, M., Tanaka, Y.   +5 more
core   +1 more source

Dual‐Gating Strategy: Ultrasound Activation of TRPV2 Channels and Borate‐Glass‐Induced Calcium Overload for Tumor Suppression

Advanced Science
Effective and precise treatment of breast cancer, particularly with bone metastasis, remains a significant challenge. Here, a dual‐gating strategy combining locally delivered borate glass (BG) and ultrasound (US) is developed for the precise and ...
Haihong Zhu, Liping Ouyang, Yangguang Huang, Ji Tan, Chunyu Liu, Qian Wang, Rongkun Huang, Wing Tak Wong, Xuanyong Liu, Haobo Pan, Yun Liao   +10 more
doaj   +1 more source

Thermoring switch for TRPV2 inactivation

Abstract The interdomain interaction plays a critical role in regulating protein activity. Although the exogenous nonselective chemical agonist, 2-aminoethoxydiphenyl borate (2-APB), is well-known for activating and inactivating the homotetrameric thermosensitive transient receptor potential vanilloid 2 (TRPV2) channel, the precise ...
openaire   +1 more source

Cannabidiol Directly Activates TRPV2 [PDF]

Biophysical Journal, 2019
Aaron Gochman, Andres Jara-Oseguera, Kenton Swartz   +2 more
openaire   +1 more source