Results 81 to 90 of about 4,775 (199)

Alteration of expression pattern of transient receptor potential vanilloid 2 and transient receptor potential vanilloid 3 in ocular surface neoplasm

Taiwan Journal of Ophthalmology, 2020
PURPOSE: We determined if the immunohistochemical expression pattern of transient receptor potential vanilloid (TRPV) family members and TRP ankyrin 1 (TRPA1) differs among a healthy conjunctival epithelium and diseased epithelia.
Ai Izutani-Kitano, Yuka Okada, Kana Ichikawa, Peter Sol Reinach, Shizuya Saika   +4 more
doaj   +1 more source

Biodegradable Mg Alloys: Enhancing Anti‐tumor Immunity in Cancer Therapy

Rare Metals, Volume 45, Issue 4, April 2026.
ABSTRACT Magnesium (Mg) alloys, as biodegradable metallic materials with excellent biocompatibility and mechanical properties, demonstrate significant advantages. In the field of immunotherapy, they present a promising potential option for enhancing therapeutic outcomes and hold broad prospects for application.
Can Feng, Ning Liang, Pingping Hu, Yingying Zhang, Jun Wang, Zhong Lu, Kai Guan, Guodong Deng, Jiandong Zhang   +8 more
wiley   +1 more source

Experimental and computational biophysics to identify vasodilator drugs targeted at TRPV2 using agonists based on the probenecid scaffold

Computational and Structural Biotechnology Journal
TRP channels are important pharmacological targets in physiopathology. TRPV2 plays distinct roles in cardiac and neuromuscular function, immunity, and metabolism, and is associated with pathologies like muscular dystrophy and cancer.
Èric Catalina-Hernández, Mario López-Martín, David Masnou-Sánchez, Marco Martins, Victor A. Lorenz-Fonfria, Francesc Jiménez-Altayó, Ute A. Hellmich, Hitoshi Inada, Antonio Alcaraz, Yuji Furutani, Alfons Nonell-Canals, Jose Luis Vázquez-Ibar, Carmen Domene, Rachelle Gaudet, Alex Perálvarez-Marín   +14 more
doaj   +1 more source

Pharmacokinetic analysis of selective TRPV2 inhibitor SET2 in rats. [PDF]

Sci Rep
The TRPV2 channel, which regulates calcium transients, has emerged as a potential therapeutic target in various diseases, including cardiovascular injury, neurodegeneration, and cancer. However, the absence of selective inhibitors has limited functional studies.
Bartosova L, Doka G, Kralova E, Balis P, Dulova U, Ferenczyova K, Kovac A, Piestansky J, Rajtik T.   +8 more
europepmc   +3 more sources

The Excelsatoxin A‐Receptor TMEM233 Modulates Nav1.8

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
TMEM233 is a largely uncharacterized transmembrane protein that enables the sensitivity of Nav1.8 to Excelasatoxin A, a naturally occurring peptide that can significantly reduce the fast inactivation of this ion channel (left) expressed in sensory neurons or different cell lines. Moreover, its presence enhances the use dependent block of Nav1.8 induced
George Oprita, Marvin J. A. Meyer, Daniel Rudolf, Inês C. A. Pombeiro Stein, Jennifer R. Deuis, Hue N. T. Tran, Thomas Durek, Klasfauseweh Tabea, Jami Sina, Stephen G. Waxman, Sulayman D. Dib‐Hajj, Alexandru Babes, Irina Vetter, Andreas Leffler   +13 more
wiley   +1 more source

Activation of Piezo1 or TRPV2 channels inhibits human ureteral contractions via NO release from the mucosa

Frontiers in Pharmacology
We aimed to investigate the expression and motor modulatory roles of several mechano-sensitive channels (MSCs) in human ureter. Human proximal ureters were obtained from eighty patients subjected to nephrectomy.
Jianing Liu, Cong Wang, Wenyu Wang, Ning Ding, Jiaxin Liu, Hanwen Liu, Jiliang Wen, Wendong Sun, Shulu Zu, Xiulin Zhang, Jieke Yan   +10 more
doaj   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, Volume 36, Issue 24, 23 March 2026.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells

, 2009
OBJECTIVE—Calcium-permeable cation channel TRPV2 is expressed in pancreatic β-cells. We investigated regulation and function of TRPV2 in β-cells. RESEARCH DESIGN AND METHODS—Translocation of TRPV2 was assessed in MIN6 cells and cultured mouse β-cells by ...
Hisanaga, Etsuko, Ueki, Kohjiro, Mori, Masatomo, Nagasawa, Masahiro, Kojima, Itaru, Kulkarni, Rohit   +5 more
core   +1 more source

Establishment of a TRPV2 knockout human embryonic stem cell line (WAe009-A-1Y) using episomal vector-based CRISPR/Cas9

Stem Cell Research
We established a TRPV2-knockout human embryonic stem cell line (WAe009-A-1Y) using a non-integrating episomal CRISPR/Cas9 system. This cell line exhibits an 8-nucleotide frameshift deletion in TRPV2 exon 2, confirmed pluripotency (97.6 % SSEA4+ cells ...
Rui Bai, Siyao Zhang, Xiaoyan Gu, Yi You, Xujie Liu   +4 more
doaj   +1 more source

Involvement of TRPV2 Activation in Intestinal Movement through Nitric Oxide Production in Mice

, 2010
Transient receptor potential channel vanilloid 2 (TRPV2) can detect various stimuli such as temperature (>52°C), stretch, and chemicals, including 2-aminoethoxydiphenyl borate, probenecid, and lysophospholipids.
Hiroshi Mihara, Koji Shibasaki, Ammar Boudaka, Akihiro Yamanaka, Makoto Tominaga, Toshiro Sugiyama   +5 more
core   +1 more source