Results 61 to 70 of about 4,775 (199)

TRPV2 calcium channel promotes breast cancer progression potential by activating autophagy

Cancer Cell International
Breast cancer, the most prevalent and aggressive tumor affecting women, requires identification of disease determinants to facilitate the development of effective therapeutic strategies.
Qing Li, Huixian Li, Ruiwen Zhu, William Chi Shing Cho, Xiaoqiang Yao, Fung Ping Leung, Gary Tse, Lai Kwok Leung, Wing Tak Wong   +8 more
doaj   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

TRPV2 correlates with endometrial cancer aggressiveness and its activation improves chemosensitivity

, 2022
Introduction Endometrial cancer (EC) is the most commonly diagnosed gynaecological malignancy in developed countries. EC comprises type I endometrioid EC and type II non-endometrioid EC, the most aggressive and with poor prognosis.
G. Santoni, M. B. Morelli, O. Marinelli, C. Amantini, C. Aguzzi, F. Maggi, M. Nabissi, L. Zeppa   +7 more
core   +1 more source

Functional Expression of Transient Receptor Potential and Piezo1 Channels in Cultured Interstitial Cells of Human-Bladder Lamina Propria

Frontiers in Physiology, 2022
The interstitial cells in bladder lamina propria (LP-ICs) are believed to be involved in sensing/afferent signaling in bladder mucosa. Transient receptor potential (TRP) cation channels act as mechano- or chemo-sensors and may underlie some of the ...
MengMeng Zhao, Zhenghao Chen, Lei Liu, Ning Ding, Jiliang Wen, Jiaxin Liu, WenZhen Wang, Nan Ge, Shulu Zu, Wei Song, Guoqing Chen, Xiulin Zhang   +11 more
doaj   +1 more source

Aβ1‐40 induces venular endothelial cell ferroptosis in cerebral amyloid angiopathy via the ATF3/xCT axis: Insights from single‐cell RNA sequencing

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Amyloid‐beta (Aβ)‐induced microvascular injury is a key pathological feature of cerebral amyloid angiopathy (CAA). Recent evidence suggests that ferroptosis is implicated in Aβ pathology; however, its cell‐type specificity and regulatory mechanisms within the cerebral microvasculature in CAA remain unclear. METHODS Single‐cell RNA
Chunmei Wu, Xiaodong Ye, Hualin Chen, Yongkang Fang, Yan Lan, Jiahe Ye, Xin Liu, Ruizhi Xiao, Suiqiang Zhu, Shanshan Huang   +9 more
wiley   +1 more source

RT-PCR analysis of the TRPV2 protein in WT and TRPV2-KO mice.

, 2015
(A) Schematic of the TRPV2 channel, including RT-PCR primer locations (*indicates TRPV2 antibody binding site). (B) RT-PCR expression results from the primer pairs (see Table 1).
Sheryl E. Koch (793860), Min Jiang (56794), Tatiana Radzyukevich (793857), Ryan Apel (793858), Nathan Robbins (491110), Xu Gao (51798), Jack Rubinstein (491112), Mindi Naticchioni (793853), Rajiv Karani (793854), Logan Fulford (634792), Margaret A. Smith (793855), Evan Onusko (793856), Judith Heiny (793859)   +12 more
core   +1 more source

Rhythmic Trafficking of TRPV2 in the Suprachiasmatic Nucleus is Regulated by Prokineticin 2 Signaling

Journal of Circadian Rhythms, 2015
The mammalian circadian clock is composed of single-cell oscillators. Neurochemical and electrical signaling among these oscillators is important for the normal expression of circadian rhythms.
Katherine J. Burton, Xiaohan Li, Jia-Da Li, Wang-Ping Hu, Qun-Yong Zhou   +4 more
doaj   +1 more source

Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

British Journal of Pharmacology, Volume 183, Issue 13, Page 3538-3557, July 2026.
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe, Julia A. Rocereta, Ruth A. Pumroy, Andreas Leffler, Michael Schaefer, Vera Moiseenkova‐Bell, Kerstin Hill   +6 more
wiley   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, Volume 13, Issue 36, 29 June 2026.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Osmosensation in TRPV2 dominant negative expressing skeletal muscle fibres.

, 2015
Increased plasma osmolarity induces intracellular water depletion and cell shrinkage followed by activation of a regulatory volume increase (RVI). In skeletal muscle, this is accompanied by transverse tubule (TT) dilation and by a membrane depolarisation
De Clippele, Marie, Zanou, Bidossessi Nadège, Shigeo Wakabayashi, Inès Dufour, Schakman, Olivier, Voets, Thomas, Zanou, Nadege, Nicolas Tajeddine, Dufour, Inès, Yuko Iwata, Thomas Voets, Allard, Bruno, Bruno Allard, Wakabayashi, Shigeo, Iwata, Yuko, Philippe Gailly, Seghers, François, Clarisse Fuster, Tajeddine, Nicolas, Nadège Zanou, Mondin, Ludivine, Gailly, Philippe, Fuster, Clarisse, Ludivine Mondin, Olivier Schakman, François Seghers, Marie de Clippele   +26 more
core   +1 more source