Results 71 to 80 of about 4,775 (199)

Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats

JCI Insight, 2022
Loss of retinal blood flow autoregulation is an early feature of diabetes that precedes the development of clinically recognizable diabetic retinopathy (DR).
Michael O’Hare, Gema Esquiva, Mary K. McGahon, Jose Manuel Romero Hombrebueno, Josy Augustine, Paul Canning, Kevin S. Edgar, Peter Barabas, Thomas Friedel, Patrizia Cincolà, Jennifer Henry, Katie Mayne, Hannah Ferrin, Alan W. Stitt, Timothy J. Lyons, Derek P. Brazil, David J. Grieve, J. Graham McGeown, Tim M. Curtis   +18 more
doaj   +1 more source

Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation

BMEMat, Volume 4, Issue 2, June 2026.
Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu, Nan Xu, Xin Li, Xiaowo Kang, Tieyuan Bian, Junsheng Lin, Hao Tang, Yinyin Bao, Lu Zhang, Hongyan Yuan, Mingxi Yao, Xingyu Jiang, Zhi Luo   +12 more
wiley   +1 more source

Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel. [PDF]

PLoS ONE, 2012
Angiotensin II (AngII) receptor (ATR) is involved in pathologic local events such as neovascularisation and inflammation including in the brain and retina.
Rene Barro-Soria, Julia Stindl, Claudia Müller, Renate Foeckler, Vladimir Todorov, Hayo Castrop, Olaf Strauß   +6 more
doaj   +1 more source

Force stimulation promotes nerve regeneration by restoring cellular energy

BMEMat, Volume 4, Issue 2, June 2026.
Mechanical stimulation can help nerves regenerate in various ways. We developed two devices (a piezo‐motor‐driven stretching device and a SAW‐based actuator) to apply mechanical stimulation to sciatic nerve and DRG neurons. Our study shows that appropriate mechanical force stimulation can promote regeneration by restoring the energy supply to the ...
Zhe Wang, Chen Cai, Hetao Xie, Yupeng Yang, Lei Li, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Meiwan Chen, Yuanhua Sang, Bing Ji, Zenan Wang   +10 more
wiley   +1 more source

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling

Glia, Volume 74, Issue 6, June 2026.
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro, Quentin Brassart, Valérie Fraulob, Laura Calzà, Wojciech Krezel   +4 more
wiley   +1 more source

Mechanobiology in Stem Cell‐Based Bioprinting

Cell Proliferation, Volume 59, Issue 5, May 2026.
Mechanobiology in stem cell‐based bioprinting is an emerging field that bridges the mechanical conditions of the bioprinting process with the regulation of stem cell behaviour for engineering living tissues. Stresses encountered during bioprinting, together with the mechanical properties of bioinks, play a critical role in regulating stem cell ...
Supeng Ding, Tiankun Liu, Rui Yao
wiley   +1 more source

Conformational plasticity in the selectivity filter of the TRPV2 ion channel [PDF]

Nature Structural & Molecular Biology, 2018
Transient receptor potential vanilloid (TRPV) channels are activated by ligands and heat and are involved in various physiological processes. In contrast to the architecturally related voltage-gated cation channels, TRPV1 and TRPV2 subtypes possess another activation gate at the selectivity filter that can open widely enough to permeate large organic ...
Lejla Zubcevic, Son Le, Huanghe Yang, Seok-Yong Lee   +3 more
openaire   +2 more sources

Evaluating FABP5 as a Therapeutic Target for Pain Management

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Background and Objective Fatty acid‐binding proteins (FABPs) are intracellular lipid transporters. Pharmacological inhibition of FABP5 is analgesic in preclinical visceral, inflammatory, neuropathic and joint pain models. Genetic knockout or knockdown of FABP5 induces analgesia in select visceral and inflammatory pain models.
William Warren, Myles Osborn, Martin Kaczocha, Andrew Yates, Saoirse O'Sullivan   +4 more
wiley   +1 more source

Cellular Localization of TRPV2 and Molecular Mechanisms of TRPV2 Translocation

, 2012
Transient receptor potential (TRP) channels perform a diverse range of functions throughout the body. The function of the ubiquitously expressed TRPV2 protein is unknown.
Marks, Christian
core  

Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2

, 2019
Thermosensitive transient receptor potential (TRP) ion channels detect changes in ambient temperature to regulate body temperature and temperature-dependent cellular activity.
Claverol, Stéphane,, Claverol, Stéphane, Echtermeyer, Frank, Tominaga, Makoto, Herzog, Christine,, Filipovic, Milos R.,, de la Roche, Jeanne,, Eberhardt, Mirjam J., Leffler, Andreas, Filipovic, Milos R., Pumroy, Ruth A., Tominaga, Makoto,, Pumroy, Ruth A.,, Zygmunt, Peter M.,, Moiseenkova-Bell, Vera Y., Zielke, Johannes,, de la Roche, Jeanne, Eberhardt, Mirjam J.,, Zygmunt, Peter M., Echtermeyer, Frank,, Zielke, Johannes, Herzog, Christine, Fricke, Tabea C.,, Fricke, Tabea C., Moiseenkova-Bell, Vera Y.,, Lund University., Leffler, Andreas,   +26 more
core   +1 more source