Results 121 to 130 of about 3,271 (166)

Inhibition of transient receptor potential vanilloid 1 (TRPV1) by a novel selective antagonist for anti-nociceptive effect on inflammatory pain without hyperthermia. [PDF]

PLoS One
Guan J, Zhao C, Zhou Q, Zhu C.
europepmc   +1 more source

CYP1B1 modulates stress and repair pathways in airway cells challenged by wood smoke particles. [PDF]

Toxicol Sci
Sun L, Almestica-Roberts M, Nguyen ND, Cowley J, Romero EG, Serna SN, Zhang P, Niu C, Memon TA, Deering-Rice CE, Reilly CA.   +10 more
europepmc   +1 more source

The potential effects, mechanisms and translational perspectives of natural products in the treatment of atopic dermatitis. [PDF]

Chin Med
Shao C, Zhang Y, Bai Y, Wu Y, Cong L, Zhao M, Ren T.   +6 more
europepmc   +1 more source

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TRPV3

2014
Transient receptor potential vanilloid-3 (TRPV3) is a Ca(2+)-permeable nonselective cation channel widely expressed in skin keratinocytes, as well as oral and nasal epithelia. TRPV3 is activated by innocuous warm as well as noxious hot temperatures. Activation of TRPV3 in skin keratinocytes causes release of multiple substances, which in turn regulate ...
Pu, Yang, Michael X, Zhu
openaire   +2 more sources

Structural basis of TRPV3 inhibition by an antagonist

Nature Chemical Biology, 2022
The TRPV3 channel plays vital roles in skin physiology. Dysfunction of TRPV3 causes skin diseases, including Olmsted syndrome. However, the lack of potent and selective inhibitors impedes the validation of TRPV3 as a therapeutic target. In this study, we identified Trpvicin as a potent and subtype-selective inhibitor of TRPV3.
Junping Fan, Linghan Hu, Zongwei Yue, Daohong Liao, Fusheng Guo, Han Ke, Daohua Jiang, Yong Yang, Xiaoguang Lei   +8 more
openaire   +2 more sources

TRPV3 endogenously expressed in murine colonic epithelial cells is inhibited by the novel TRPV3 blocker 26E01

Cell Calcium, 2020
TRPV3 is a Ca2+-permeable cation channel, prominently expressed by keratinocytes where it contributes to maintaining the skin barrier, skin regeneration, and keratinocyte differentiation. However, much less is known about its physiological function in other tissues and there is still a need for identifying novel and efficient TRPV3 channel blockers. By
Carina Glas, Kerstin Hill, Michael Schaefer   +2 more
exaly   +3 more sources

A pentameric TRPV3 channel with a dilated pore

Nature, 2023
Transient receptor potential (TRP) channels are a large, eukaryotic ion channel superfamily that control diverse physiological functions, and therefore are attractive drug targets1-5. More than 210 structures from more than 20 different TRP channels have been determined, and all are tetramers4. Despite this wealth of structures, many aspects concerning
Shifra Lansky, John Michael Betancourt, Jingying Zhang, Yining Jiang, Elizabeth D. Kim, Navid Paknejad, Crina M. Nimigean, Peng Yuan, Simon Scheuring   +8 more
openaire   +2 more sources

Analgesic Potential of TRPV3 Antagonists

Current Topics in Medicinal Chemistry, 2011
The vanilloid subfamily of transient receptor potential (TRPV) ion channels serves critical functions in sensory signaling in specialized cells and intact organisms ranging from yeast to primates. As thermosensors, chemosensors, and/or mechanosensors, these channels monitor the local environment and integrate and respond to multiple stimuli ...
Regina M, Reilly, Philip R, Kym
openaire   +2 more sources

Thermally Activated TRPV3 Channels

2014
TRPV3 is a temperature-sensitive transient receptor potential (TRP) ion channel. The TRPV3 protein functions as a Ca(2+)-permeable nonselective cation channel with six transmembrane domains forming a tetrameric complex. TRPV3 is known to be activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants.
Jialie, Luo, Hongzhen, Hu
openaire   +2 more sources

Unlocking the therapeutic potential of TRPV3: Insights into thermosensation, channel modulation, and skin homeostasis involving TRPV3

BioEssays
AbstractRecent insights reveal the significant role of TRPV3 in warmth sensation. A novel finding elucidated how thermosensation is affected by TRPV3 membrane abundance that is modulated by the transmembrane protein TMEM79. TRPV3 is a warmth‐sensitive ion channel predominantly expressed in epithelial cells, particularly skin keratinocytes.
Jing Lei, Makoto Tominaga
exaly   +3 more sources