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Abstract Both hot and cold sensation of the homotetrameric thermosensitive transient receptor potential vanilloid 1–4 (TRPV1-4) channels have been predicted by a single Gibbs-Helmholtz equation for a change in molar heat capacity. However, cold activation has not been confirmed for those heat-responsive TRPV1-4 channels.
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Cold unfolding of heat-responsive TRPV3

Abstract The homotetrameric thermosensitive transient receptor potential vanilloid 1–4 (TRPV1-4) channels in sensory neurons are strongly responsive to heat stimuli. However, their cold activations have not been reported in line with the nonzero heat capacity difference during heat or cold unfolding transitions.
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Mechanism of Proton Inhibition of TRPV3 [PDF]

Biophysical Journal, 2019
Haiyuan Wang +3 more
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Whole genome sequencing analysis of alpaca suggests TRPV3 as a candidate gene for the suri phenotype

BMC Genomics
Background Alpaca is a domestic South American camelid probably arising from the domestication of two wild camelids, the vicugna and the guanaco. Two phenotypes are described for alpaca, known as huacaya and suri.
Stefano Pallotti +6 more
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Structural Basis of TRPV3 Activation and Inactivation [PDF]