Results 101 to 110 of about 5,561 (208)
BMC Neurology, 2007 Background Transient receptor potential (TRP) receptors expressed by primary sensory neurons mediate thermosensitivity, and may play a role in sensory pathophysiology.
Bountra Chas +8 more
doaj +1 more source
TRP Channels: Current Perspectives in the Adverse Cardiac Remodeling [PDF]
, 2019 Calcium is an important second messenger required not only for the excitation-contraction coupling of the heart but also critical for the activation of cell signaling pathways involved in the adverse cardiac remodeling and consequently for the heart ...
Calderón Sánchez, Eva María +7 more
core +1 more source
Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.ABSTRACT Cyanide is widely recognized for its potent toxicity, yet evidence shows that concentrations below 1 μM may enhance cytochrome c oxidase activity and have a regulatory function. Recent findings also demonstrate that mammalian cells, including endothelial cells, produce cyanide endogenously, where it can modulate mitochondrial bioenergetics ...
Elif Alan‐Albayrak, Ulf Simonsen
wiley +1 more source
Molecules, 2020 Bioassay-guided fractionation of the ethanol extract of whole herbs of Achillea alpina led to the isolation of isochlorogenic acids A and B as transient receptor potential vanilloid 3 (TRPV3) channel antagonists by using a calcium fluorescent assay.
Shi-Wei Sun +7 more
doaj +1 more source
Metabotropic glutamate receptor 2/3 (mGluR2/3) activation suppresses TRPV1 sensitization in mouse, but not human sensory neurons [PDF]
, 2018 The use of human tissue to validate putative analgesic targets identified in rodents is a promising strategy for improving the historically poor translational record of preclinical pain research.
Baranger, David A.A. +5 more
core +2 more sources
The Therapeutic Potential of Cannabidiol in Skin Conditions
Journal of Cosmetic Dermatology, Volume 24, Issue 11, November 2025.ABSTRACT Background Dermatological disorders can have a negative impact on quality of life. Cannabidiol (CBD) is a phytocannabinoid found in the Cannabis sativa L. plant. It has multiple molecular targets, many of which are expressed in the skin, and may have therapeutic potential in several skin conditions. Aims This review aims to provide an overview
Maria C. Redmond, David P. Finn
wiley +1 more source
TRPV4 is the temperature-sensitive ion channel of human sperm. [PDF]
, 2018 Ion channels control the ability of human sperm to fertilize the egg by triggering hyperactivated motility, which is regulated by membrane potential, intracellular pH, and cytosolic calcium.
Lishko, Polina V +2 more
core +2 more sources
Zebrafish TRPA1 Channels Are Required for Chemosensation But Not for Thermosensation or Mechanosensory Hair Cell Function [PDF]
, 2008 Transient receptor potential (TRP) ion channels have been implicated in detecting chemical, thermal, and mechanical stimuli in organisms ranging from mammals to Caenorhabditis elegans.
Caron, Sophie +10 more
core +4 more sources
ChemMedChem, Volume 20, Issue 20, October 15, 2025.Beyond their established role as nonsteroidal anti‐inflammatory drugs (NSAIDs), fenamates (niflumic, flufenamic, mefenamic, meclofenamic, and tolfenamic acids) have recently been identified as modulators of cationic ion channels. This review highlights their differential effects on ion channel activity and explores their potential for repurposing in ...
Paola Laghetti +4 more
wiley +1 more source
Molecular triggers of egg activation at fertilization in mammals [PDF]
, 2016 In mammals, the sperm activates the development of the egg by triggering a series of oscillations in the cytosolic-free Ca2+concentration (Ca2+i). The sperm triggers these cytosolic Ca2+ioscillations after sperm–egg membrane fusion, as well as after ...
Sanders, Jessica R., Swann, Karl
core +1 more source