Results 81 to 90 of about 5,561 (208)

Dissecting domain-specific evolutionary pressure profiles of transient receptor potential vanilloid subfamily members 1 to 4. [PDF]

PLoS ONE, 2014
The transient receptor potential vanilloid family includes four ion channels-TRPV1, TRPV2, TRPV3 and TRPV4-that are represented within the vertebrate subphylum and involved in several sensory and physiological processes.
Pau Doñate-Macián, Alex Perálvarez-Marín   +1 more
doaj   +1 more source

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK [PDF]

, 2019
Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear.
Changchuan Xie, Chen-Song Zhang, Cixiong Zhang, D. Grahame Hardie, Dong Jiang, Hai-Long Piao, Jianfeng Wu, Jie Chen, Jin-Wei Feng, Jiwen Cui, Li Yu, Meiqin Hu, Mengqi Li, Mengqi Li, Qing-Feng Liu, Sheng-Cai Lin, Shu-Yong Lin, Teng Ma, Wen Wang, Xiao Tian, Xiao-Song Xie, Xiaotong Li, Xin Chen, Yanyan Yang, Yaying Wu, Ying Li, Ying Liu, Yu-Qing Wu, Yue Zong, Zhiyun Ye, Zhizhong Lin, Zhuan Zhou, 宗岳, 张宸崧, 林圣彩   +34 more
core   +5 more sources

Development and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis

Arthritis Care &Research, Volume 77, Issue 12, Page 1409-1417, December 2025.
Objective Several single‐nucleotide polymorphisms (SNPs) have been associated with chronic pain syndromes. Our objective was to determine whether genetic variants are associated with pain and disease activity in rheumatoid arthritis (RA). Methods Participants were included from two independent RA cohorts: FORWARD (National Databank for Rheumatic ...
Katie J. McMenamin, Thomas R. Riley IV, Kristin Wipfler, Kaleb Michaud, Austin Wheeler, Bryant R. England, Brian Sauer, Katherine D. Wysham, Rui Xiao, Michael March, Grant W. Cannon, Sylvanus Toikumo, Henry R. Kranzler, Rachel L. Kember, Ted R. Mikuls, Joshua F. Baker   +15 more
wiley   +1 more source

Case report: Novel p.Val306Met missense mutation in TRPV3 in a case of Olmsted syndrome accompanied by squamous cell carcinoma

Frontiers in Oncology
Olmsted syndrome (OS) is a rare congenital skin disorder, typically characterized by symmetrical, severe palmoplantar and periorificial keratoderma, often accompanied by alopecia, and onychodystrophy, with varying degrees of pruritus and pain.
Yangyang Hao, Rong Wu, Xi Chen, Yunjia Shen, Mengwei Chou, Jianqiang Yang   +5 more
doaj   +1 more source

Modulatory effects of the fruits of Tribulus terrestris L. on the function of atopic dermatitis-related calcium channels, Orai1 and TRPV3

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To examine the effects of Tribulus terrestris L. (T. terrestris) extract on the modulation of calcium channels to evaluate its use in topical agents for treatment of atopic dermatitis. Methods: The 70% methanol extract of T.
Joo Hyun Nam, Hyo Won Jung, Young-Won Chin, Woo Kyung Kim, Hyo Sang Bae   +4 more
doaj   +1 more source

Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel [PDF]

, 2014
The TRPV4 calcium-permeable cation channel plays important physiological roles in osmosensation, mechanosensation, cell barrier formation, and bone homeostasis. Recent studies reported that mutations in TRPV4, including some in its ankyrin repeat domain (
Gaudet, Rachelle, Inada, Hitoshi, Procko, Erik, Sotomayor, Marcos   +3 more
core   +2 more sources

Transient Receptor Potential Channels as Key Regulators of Neuroinflammation in Neurological Disorders: Mechanistic Insights, Therapeutic Potentials, and Future Directions

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
This study elucidates the central role of transient receptor potential (TRP) channels in driving neuroinflammation across neurological disorders. Acting as critical molecular sensors on neurons and glial cells, TRP channels' activation initiates downstream pathways that promote the release of proinflammatory cytokines, a pathological mechanism in ...
Daji Guo, Mengjiao Cai, Yanmin Xian, Yinyin Chen, Yujun Feng, Chun Hu, Lizhang Zeng, Lei Shi, Shiqing Zhang   +8 more
wiley   +1 more source

Inhibition of Cutaneous TRPV3 Channels by Natural Caffeic Acid for the Alleviation of Skin Inflammation

Molecules
Natural caffeic acid (CA) and its analogues have been studied for their potential applications in the treatment of various inflammatory and infectious skin diseases.
Guoji Zhang, Liqin Wang, Yaxuan Qu, Shilun Mo, Xiaoying Sun, Kewei Wang   +5 more
doaj   +1 more source

Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. [PDF]

PLoS ONE, 2008
Transient receptor potential (TRP) ion channels mediate key aspects of taste, smell, pain, temperature sensation, and pheromone detection. To deepen our understanding of TRP channel physiology, we require more diverse pharmacological tools.
Stephanie C Stotz, Joris Vriens, Derek Martyn, Jon Clardy, David E Clapham   +4 more
doaj   +1 more source

Citral inibe a inflamação aguda e nocicepção em camundongos: o papel dos receptores TLR4 e TLR2/DECTINA-1 [PDF]

, 2015
TCC(graduação) - Universidade Federal de Santa Catarina. Araranguá. Fisioterapia.Citral (3,7-dimethyl-2,6-octadienal), um monoterpeno de cadeia aberta e principal componente bioativo do capim limão, apresenta diferentes propriedades farmacológicas, tais ...
Gonçalves, Elaine Cristina Dalazen
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