Results 91 to 100 of about 5,561 (208)
Understand spiciness: mechanism of TRPV1 channel activation by capsaicin. [PDF]
, 2017 Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin activates this channel has been under extensive investigation using a variety ...
Yang, Fan, Zheng, Jie
core +2 more sources
Artificial skin sensation for neuroprosthetic hands
FlexMat, Volume 2, Issue 4, Page 458-474, December 2025.In this review, Li et al. provide a systematic summary of the design strategy and performance of flexible tactile sensors for neuroprosthetic hands, which can efficiently transduce environmental stimuli such as pressure, temperature, and pain. The comparisons of sensing modality between human skin and each flexible sensor subtype are also discussed ...
Yue Li, Tie Li, Ting Zhang, Zheng Liu
wiley +1 more source
Tonic Inhibition of TRPV3 by Mg2+ in Mouse Epidermal Keratinocytes [PDF]
Journal of Investigative Dermatology, 2012 The transient receptor potential vanilloid 3 channel (TRPV3) is abundantly expressed in epidermal keratinocytes and has important roles in sensory biology and skin health. Mg(2+) deficiency causes skin disorders under certain pathological conditions such as type 2 diabetes mellitus.
Luo, Jialie +3 more
openaire +2 more sources
Sensory Neuroscience, Volume 1, Issue 3, December 2025.ABSTRACT Sensory neuron disorders, such as peripheral neuropathies and trigeminal neuralgia, cause chronic pain and sensory dysfunction; however, regenerative treatments are limited. Human pluripotent stem cells (hPSCs) provide a powerful platform to model these diseases by generating functional sensory neuron subtypes, including nociceptors and ...
Pushpanathan Muthuirulan +3 more
wiley +1 more source
Structural basis of temperature sensation by the TRP channel TRPV3 [PDF]
Nature Structural & Molecular Biology, 2019 We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergo α-to-π transitions.
Appu K. Singh +5 more
openaire +3 more sources
eLife, 2019 The Transient Receptor Potential Vanilloid 1 (TRPV) channel is activated by an array of stimuli, including heat and vanilloid compounds. The TRPV1 homologues TRPV2 and TRPV3 are also activated by heat, but sensitivity to vanilloids and many other ...
Feng Zhang +2 more
doaj +1 more source
TRPV4: Molecular Conductor of a Diverse Orchestra [PDF]
, 2016 Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective cation channel, originally described in 2000 by research teams led by Schultz ( Nat Cell Biol 2: 695 –702, 2000) and Liedtke ( Cell 103: 525–535, 2000).
Cibelli, Mario +5 more
core +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
Basic and Clinical Neuroscience, 2016 Introduction: Stimulation of peptidergic fibers activates microglia in the dorsal horn. Microglia activation causes fractalkine (FKN) release, a neuron-glia signal, which enhances pain.
Sasan Gazerani +3 more
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