Results 71 to 80 of about 5,561 (208)

Ubiquitination and proteosome-dependent degradation of the activated form of human liver-enriched transcription factor CREB-H regulated by protein kinase A [PDF]

, 2014
Poster Presentation - Theme 1: Cell biologyCREB-H is a membrane-bound bZIP transcription factor which is mainly expressed in liver and small intestine. CREB-H plays important roles in the regulation of lipid metabolism, iron metabolism, gluconeogenesis ...
Chan, CP, Cheng, Y, Deng, J, Gao, W, Jin, DY, Tang, VHM   +5 more
core  

Activation of Transient Receptor Potential Vanilloid 3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes [PDF]

, 2018
K
Angyal, Ágnes, Béke, Gabriella, Bíró, Tamás, Kawada, Naoki, Kemény, Lajos, Kistamás, Kornél, Lisztes, Erika, Mihály, Johanna, Mori, Tomohiro, Nánási, Péter Pál, Szegedi, Andrea, Szöllősi, Attila Gábor, Vasas, Nikolett, Yanagida, Takashi   +13 more
core   +1 more source

Towards a digital cancer cell twin: External pharmacological validation of a mechanistic A549 electrophysiology model

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
A mechanistic in‐silico model of A549 lung adenocarcinoma electrophysiology reproduces drug‐modulated ion‐channel responses across wild‐type and erlotinib‐resistant phenotypes. By accurately capturing KCa1.1 and KCa3.1 inhibition and phenotype‐specific KCa remodelling within biologically plausible bounds, the model provides a validated foundation for ...
Celine Desoyer, Martin Ruf, Christian Baumgartner   +2 more
wiley   +1 more source

A Comprehensive Review of Acne Treatments: Unpacking the Chemical Structures and Effective Bioactive Compounds

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Acne vulgaris is a frequent skin disorder, affecting a large part of the population worldwide, and strongly influencing not only the physical but also the mental aspects of health. The choice of therapy for acne vulgaris is a very difficult one because the multifactorial causality of the disease and interindividual ...
Mobina Tajdari, Setare Abolghasemi, Elham Khanniri, Maryam Bayanati, Rahil Hakimimofrad, Mohammad Mahboubi‐Rabbani   +5 more
wiley   +1 more source

Yifei Decoction Regulates the NGF/TRKA/PI3K/AKT Signaling Axis to Inhibit the Epithelial–Mesenchymal Transformation and Proliferation of Pulmonary Epithelial Cells in Bleomycin‐Induced Pulmonary Fibrogenesis

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Background It was important to find better therapeutic drugs for idiopathic pulmonary fibrosis (IPF), and in our previous study, Yifei decoction (YFT) alleviated IPF. A deeper understanding of its mechanisms of action could aid in the development of novel treatment strategies.
Lijuan Chen, Chengzhong Lan, Xiangli Deng, Mei Wu, Mei Shao, Mei Yang, Xinwen Ma, Fen Huang, Haiyin Wu, Lipi Buch   +9 more
wiley   +1 more source

Alteration of expression pattern of transient receptor potential vanilloid 2 and transient receptor potential vanilloid 3 in ocular surface neoplasm

Taiwan Journal of Ophthalmology, 2020
PURPOSE: We determined if the immunohistochemical expression pattern of transient receptor potential vanilloid (TRPV) family members and TRP ankyrin 1 (TRPA1) differs among a healthy conjunctival epithelium and diseased epithelia.
Ai Izutani-Kitano, Yuka Okada, Kana Ichikawa, Peter Sol Reinach, Shizuya Saika   +4 more
doaj   +1 more source

Genome-wide analysis study of gestational diabetes mellitus and related pathogenic factors in a Chinese Han population

BMC Pregnancy and Childbirth, 2023
Background Gestational diabetes mellitus (GDM) affects the metabolism of both the mother and fetus during and after pregnancy. Genetic factors are important in the pathogenesis of GDM, and associations vary by ethnicity.
Shufan Yue, Ling Pei, Fenghua Lai, Huangmeng Xiao, Zeting Li, Rui Zeng, Li Chen, Wenzhan Chen, Huiling Liu, Yanbing Li, Haipeng Xiao, Xiaopei Cao   +11 more
doaj   +1 more source

Nrf2 Activation in Inflammatory Diseases: A Review of Natural and Synthetic Modulators

Oxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
The nuclear factor erythroid 2–related factor 2 (Nrf2) pathway is a central regulator of the cellular antioxidant response, playing a key role in modulating inflammation and defending against oxidative stress‐induced damage. A range of natural and synthetic compounds, including dimethyl fumarate, bardoxolone, oltipraz, RTA‐408, ursodiol, curcumin ...
Vitória B. Costa, Iolanda A. F. de Matos, Isabela R. G. Nogueira, Mariely A. de Godoi, Fábio R. M. Leite, Morgana R. Guimarães-Stabili, Dario Ramirez   +6 more
wiley   +1 more source

Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway

iScience, 2023
Summary: Global warming and rising temperature significantly increase the incidence of heat stress, which is known to affect the process of inflammation and aging. However, the effect of heat stress on skin melanogenesis is not fully known. We found that
Lan Zhang, Hongliang Zeng, Ling Jiang, Chuhan Fu, Yushan Zhang, Yibo Hu, Xiaolin Zhang, Lu Zhu, Fan Zhang, Jinhua Huang, Jing Chen, Qinghai Zeng   +11 more
doaj   +1 more source

Implication of intracellular chloride channel in extracellular matrix remodeling in pressure‐overloaded mice and patients with dilated cardiomyopathy

Physiological Reports, Volume 14, Issue 1, January 2026.
Abstract Chloride intracellular channels (CLICs) are important in cardiac cellular physiology. We aimed to determine the pathophysiological roles of CLICs in the heart. For this, we analyzed CLIC expression in cardiomyocytes in a mouse transverse aortic constriction (TAC) model to induce cardiac hypertrophy and failure, as well as in ventricular ...
Gaku Oguri, Seitaro Nomura, Takafumi Nakajima, Hironobu Kikuchi, Syotaro Obi, Issei Komuro, Norihiko Takeda, Shigeru Toyoda, Toshiaki Nakajima   +8 more
wiley   +1 more source