Results 71 to 80 of about 3,271 (166)

Towards a digital cancer cell twin: External pharmacological validation of a mechanistic A549 electrophysiology model

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
A mechanistic in‐silico model of A549 lung adenocarcinoma electrophysiology reproduces drug‐modulated ion‐channel responses across wild‐type and erlotinib‐resistant phenotypes. By accurately capturing KCa1.1 and KCa3.1 inhibition and phenotype‐specific KCa remodelling within biologically plausible bounds, the model provides a validated foundation for ...
Celine Desoyer, Martin Ruf, Christian Baumgartner   +2 more
wiley   +1 more source

Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action

Nature Communications
Our skin safeguards the body homeostasis for health and also provides psychological consolation in social life. Natural essential oils are widely used for skin maintenance, while the molecular target and mechanism of action remain largely unknown.
Yang Li, Xuteng Lu, Xufeng Cheng, Keyu Xia, Junyan Hu, Peiyu Wang, Peiyuan Pang, Bomin Gao, Demeng Sun, Zhuzhen Zhang, Dongdong Li, Zengqin Deng, Changlin Tian, Chang Xie, Jing Yao   +14 more
doaj   +1 more source

Camphor, Applied Epidermally to the Back, Causes Snout- and Chest-Grooming in Rats: A Response Mediated by Cutaneous TRP Channels

Pharmaceuticals, 2019
Thermoregulatory grooming, a behavioral defense against heat, is known to be driven by skin-temperature signals. Because at least some thermal cutaneous signals that drive heat defenses are likely to be generated by transient receptor potential (TRP ...
Débora T. Ishikawa, Robson Cristiano Lillo Vizin, Cristiane Oliveira de Souza, Daniel Carneiro Carrettiero, Andrej A. Romanovsky, Maria Camila Almeida   +5 more
doaj   +1 more source

Erlotinib therapy for Olmsted syndrome with p.L655P missense mutation in the TRPV3 gene: a case report

Frontiers in Medicine
Olmsted syndrome (OS) is a rare disorder characterized by a mutilating palmoplantar keratoderma and periorificial keratotic plaques, but which shows considerable clinical heterogeneity. Recently, transient receptor potential vanilloid 3 (TRPV3) mutations
Jia Zhang, MengYue Guo, DongYang Yuan, JinYang Wei, Hongzhou Cui, Hongzhou Cui   +5 more
doaj   +1 more source

Transient Receptor Potential Cation Channel Subfamily Vanilloid 4 and 3 in the Inner Ear Protect Hearing in Mice

Frontiers in Molecular Neuroscience, 2019
The transient receptor potential cation channel, vanilloid type (TRPV) 3, is a member of the TRPV subfamily that is expressed predominantly in the skin, hair follicles, and gastrointestinal tract. It is also distributed in the organ of Corti of the inner
Shengnan Wang, Shengnan Wang, Shengnan Wang, Shengnan Wang, Qiaowei Geng, Qiaowei Geng, Qiaowei Geng, Qiaowei Geng, Lifang Huo, Lifang Huo, Lifang Huo, Yirui Ma, Yirui Ma, Yirui Ma, Yirui Ma, Yiting Gao, Yiting Gao, Yiting Gao, Yiting Gao, Wei Zhang, Wei Zhang, Wei Zhang, Hailin Zhang, Hailin Zhang, Hailin Zhang, Hailin Zhang, Ping Lv, Ping Lv, Ping Lv, Ping Lv, Zhanfeng Jia, Zhanfeng Jia, Zhanfeng Jia, Zhanfeng Jia   +33 more
doaj   +1 more source

Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain

BMC Women's Health, 2005
Background Breast pain and tenderness affects 70% of women at some time. These symptoms have been attributed to stretching of the nerves with increase in breast size, but tissue mechanisms are poorly understood.
Facer Paul, Holdcroft Anita, Wan Elaine, Gopinath Preethi, Davis John B, Smith Graham D, Bountra Chas, Anand Praveen   +7 more
doaj   +1 more source

Papillomavirus-like particles as vectors for ex vivo gene therapy of the skin

Molecular Therapy: Nucleic Acids
Ex vivo gene delivery to the skin utilizing retroviral vectors has been demonstrated to be a viable clinical option for replacement of defective genes.
Francesco Diversi, Juliette Dabin, Elisa Mazza, Mirko Rinaldin, Fernanda de Castro Reis, Jamie A. Hackett, Paul A. Heppenstall   +6 more
doaj   +1 more source

Molecular basis of TRPV3 channel blockade by intracellular polyamines

Communications Biology
ThermoTRPV1-4 channels are involved in the regulation of multiple physiological processes, including thermo- and pain perception, thermoregulation, itch, and nociception and therefore tight control of their activity is a critical requirement for correct ...
Jingying Zhang, Peng Yuan, Colin G. Nichols, Grigory Maksaev   +3 more
doaj   +1 more source

Ligand-induced cold activation of TRPV3

Abstract Both hot and cold sensation of the homotetrameric thermosensitive transient receptor potential vanilloid 1–4 (TRPV1-4) channels have been predicted by a single Gibbs-Helmholtz equation for a change in molar heat capacity. However, cold activation has not been confirmed for those heat-responsive TRPV1-4 channels.
openaire   +2 more sources

Effects of electroacupuncture at “Hegu” （LI4） and “Quchi” （LI11） on Parthanatos in atopic dermatitis mice by regulating the PAR2/TRPV3 pathway

针刺研究
ObjectiveTo observe the effect of electroacupuncture （EA） at “Hegu” （LI4） and “Quchi” （LI11） on skin inflammatory injury， itching， and poly（ADP-ribose） polymerase 1 （PARP1）-dependent cell death （Parthanatos） in mice with atopic dermatitis （AD） based on ...
HUANG Liu-yang, YANG Shu-rui, TANG Qian, LU Da-min, XUE Ting-zheng, YANG Wen-zhuo, HE Qian-li, LIANG Feng-xia, CHEN Rui   +8 more
doaj   +2 more sources