Results 51 to 60 of about 3,271 (166)

Echinacoside Ameliorates UVB-Induced Skin Damage Through Selective Inhibition of the Cutaneous TRPV3 Channel

Molecules
Excessive exposure to ultraviolet B (UVB) radiation can lead to skin damage, such as erythema and swelling. Echinacoside is a key effective ingredient of medicinal plant Cistanche deserticola commonly used for therapies and treatments for anti-aging and ...
Shilun Mo, Xinying Yue, Yaxuan Qu, Guoji Zhang, Liqin Wang, Xiaoying Sun   +5 more
doaj   +1 more source

Thermoring basis for the TRPV3 bio-thermometer

Scientific Reports, 2023
Abstract The thermosensitive transient receptor potential (TRP) channels are well-known as bio-thermometers with specific temperature thresholds and sensitivity. However, their precise structural origins are still mysterious. Here, graph theory was used to test how the temperature-dependent non-covalent interactions as identified in ...
openaire   +4 more sources

Role of TRPV3 in immune response to development of dermatitis [PDF]

Journal of Inflammation, 2009
Abstract Background Recently, it has been reported that the Gly573Ser substitution of transient receptor potential V3 (TRPV3) leads to increased ion-channel activity in keratinocytes. Our previous studies have indicated that the spontaneous hairless and dermatitis phenotypes of DS-Nh mice, which were newly established
Hirasawa Tsutomu, Yoshioka Takeshi, Imura Kinichi, Sakata Tsuneaki   +3 more
openaire   +3 more sources

When can AlphaFold predict the oligomeric states of proteins?

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Homooligomerisation is a prevalent and important process that many proteins undergo to form the quaternary structures required for biological function. However, determining oligomeric states and structures experimentally remains technically challenging and time‐consuming for many proteins.
Yiechang Lin, Ciara Wallis, Ben Corry
wiley   +1 more source

The Xenopus tropicalis orthologue of TRPV3 is heat sensitive [PDF]

Journal of General Physiology, 2015
Thermosensitive members of the transient receptor potential (TRP) family of ion channels (thermal TRP channels) play a crucial role in mammalian temperature sensing. Orthologues of these channels are present in lower vertebrates and, remarkably, some thermal TRP orthologues from different species appear to mediate opposing responses to temperature. For
Liu, Beiying, Qin, Feng
openaire   +2 more sources

Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

British Journal of Pharmacology, Volume 183, Issue 13, Page 3538-3557, July 2026.
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe, Julia A. Rocereta, Ruth A. Pumroy, Andreas Leffler, Michael Schaefer, Vera Moiseenkova‐Bell, Kerstin Hill   +6 more
wiley   +1 more source

Hysteresis of gating underlines sensitization of TRPV3 channels [PDF]

Journal of General Physiology, 2011
Vanilloid receptors of the transient receptor potential family have functions in thermal sensation and nociception. Among them, transient receptor potential vanilloid (TRPV)3 displays a unique property by which the repeated stimulation causes successive increases in its activity.
Liu, Beiying, Yao, Jing, Zhu, Michael X., Qin, Feng   +3 more
openaire   +2 more sources

The Effect of Carvacrol on Lipid Profiles, Oxidative Stress, Inflammatory Markers, and Renal Injury in STZ‐Induced Diabetic Rats

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Carvacrol administration is associated with improvements in lipid profiles, attenuation of oxidative stress, and modulation of inflammatory markers, including C‐reactive protein (CRP). The diagram summarizes systemic effects across major organs, highlighting potential protective roles against inflammation‐related oxidative damage and kidney injury ...
Vida Seyedmousavi Dijvejin, Vahid Asghariazar, Helda Tutunchi, Elnaz Faramarzi, Hamed Shoorei, Rouhallah Moradpour, Mehdi Asghari Vostakolaei   +6 more
wiley   +1 more source

Inhibition of Cutaneous TRPV3 Channels by Natural Caffeic Acid for the Alleviation of Skin Inflammation

Molecules
Natural caffeic acid (CA) and its analogues have been studied for their potential applications in the treatment of various inflammatory and infectious skin diseases.
Guoji Zhang, Liqin Wang, Yaxuan Qu, Shilun Mo, Xiaoying Sun, Kewei Wang   +5 more
doaj   +1 more source

Genome-wide analysis study of gestational diabetes mellitus and related pathogenic factors in a Chinese Han population

BMC Pregnancy and Childbirth, 2023
Background Gestational diabetes mellitus (GDM) affects the metabolism of both the mother and fetus during and after pregnancy. Genetic factors are important in the pathogenesis of GDM, and associations vary by ethnicity.
Shufan Yue, Ling Pei, Fenghua Lai, Huangmeng Xiao, Zeting Li, Rui Zeng, Li Chen, Wenzhan Chen, Huiling Liu, Yanbing Li, Haipeng Xiao, Xiaopei Cao   +11 more
doaj   +1 more source