Results 51 to 60 of about 5,561 (208)

Hysteresis of gating underlines sensitization of TRPV3 channels [PDF]

Journal of General Physiology, 2011
Vanilloid receptors of the transient receptor potential family have functions in thermal sensation and nociception. Among them, transient receptor potential vanilloid (TRPV)3 displays a unique property by which the repeated stimulation causes successive increases in its activity.
Liu, Beiying, Yao, Jing, Zhu, Michael X., Qin, Feng   +3 more
openaire   +2 more sources

Structure of the full-length TRPV2 channel by cryo-EM. [PDF]

, 2016
Transient receptor potential (TRP) proteins form a superfamily Ca(2+)-permeable cation channels regulated by a range of chemical and physical stimuli. Structural analysis of a 'minimal' TRP vanilloid subtype 1 (TRPV1) elucidated a mechanism of channel ...
Cohen, Matthew R, Huynh, Kevin W, Jiang, Jiansen, Lodowski, David T, Moiseenkova-Bell, Vera Y, Samanta, Amrita, Zhou, Z Hong   +6 more
core   +2 more sources

Integrative analysis of TRPV family to prognosis and immune infiltration in renal clear cell carcinoma

Channels, 2022
The transient receptor potential vanilloid (TRPV) family has been preliminarily discovered to play an important role in various cancers, including clear cell renal cell carcinoma (ccRCC), which is closely associated with immune infiltration. However, the
Zixuan Gong, Jiaheng Xie, Liang Chen, Qikai Tang, Yiming Hu, Aiming Xu, Zengjun Wang   +6 more
doaj   +1 more source

Analysis of metabolic effects of menthol on WFS1-deficient mice [PDF]

, 2016
In this study, we investigated the physiological regulation of energy metabolism in wild-type (WT) and WFS1-deficient (Wfs1KO) mice by measuring the effects of menthol treatment on the O2 consumption, CO2 production, rectal body temperature, and heat ...
Ehrlich, Marite, Ivask, Marilin, Kõks, Sulev, Raasmaja, Atso   +3 more
core   +1 more source

Gating of human TRPV3 in a lipid bilayer

Nature Structural & Molecular Biology, 2020
The transient receptor potential cation channel subfamily V member 3 (TRPV3) channel plays a critical role in skin physiology, and mutations in TRPV3 result in the development of a congenital skin disorder, Olmsted syndrome. Here we describe multiple cryo-electron microscopy structures of human TRPV3 reconstituted into lipid nanodiscs, representing ...
Zengqin Deng, Grigory Maksaev, Michael Rau, Zili Xie, Hongzhen Hu, James A. J. Fitzpatrick, Peng Yuan   +6 more
openaire   +3 more sources

FRET analysis of the temperature-induced structural changes in human TRPV3

Scientific Reports, 2023
Transient receptor potential vanilloid member 3 (TRPV3) is an ion channel that plays a critical role in temperature sensing in skin. There have been active studies on how TRPV3, which is also known as one of the temperature-sensitive transient receptor ...
Jinyoung Kim, Jongdae Won, Dong Kyu Chung, Hyung Ho Lee   +3 more
doaj   +1 more source

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. [PDF]

, 2012
The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation of TRPV1 elicit similar pungent, painful sensation, the molecular mechanism underlying ...
Cao, Xu, Cui, Yuanyuan, Wang, KeWei, Yang, Fan, Yarov-Yarovoy, Vladimir, Zheng, Jie   +5 more
core   +1 more source

Recent advances in our understanding of the structure and function of more unusual cation channels. [PDF]

, 2019
As their name implies, cation channels allow the regulated flow of cations such as sodium, potassium, calcium, and magnesium across cellular and intracellular membranes.
Brown, Brandon M, Nguyen, Hai M, Wulff, Heike   +2 more
core   +1 more source

Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

Veterinary Dermatology, EarlyView.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon, Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Didier Pin   +5 more
wiley   +1 more source

Potentiation of TRPV3 channel function by unsaturated fatty acids [PDF]

Journal of Cellular Physiology, 2006
AbstractTransient receptor potential vanilloid (TRPV) channels are polymodal detectors of multiple environmental factors, including temperature, pH, and pressure. Inflammatory mediators enhance TRPV function through multiple signaling pathways. The lipoxygenase and epoxygenase products of arachidonic acid (AA) metabolism have been shown to directly ...
Hong-Zhen, Hu, Rui, Xiao, Chunbo, Wang, Na, Gao, Craig K, Colton, Jackie D, Wood, Michael X, Zhu   +6 more
openaire   +2 more sources