Results 41 to 50 of about 5,561 (208)
TRPV3 in skin thermosensation and temperature responses. [PDF]
J Physiol SciHuman skin, as a sophisticated sensory organ, is able to detect subtle changes in ambient temperature. This thermosensory capability is primarily mediated by temperature-sensitive TRP channels expressed in both sensory neurons and keratinocytes. Among these, TRPV3, which responds to warm temperatures and plays a crucial role in various skin functions ...
Lei J, Tominaga M.
europepmc +3 more sources
Kv7/M-type potassium channels in rat skin keratinocytes. [PDF]
, 2013 Skin keratinocytes fulfil important signalling and protective functions. Immunocytochemical experiments revealed the unexpected presence of immunoreactivity for the M-type potassium channel subunit Kv7.2 in the keratinocyte layer of intact rat paw skin ...
Brown, DA +4 more
core +1 more source
Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine
Nature Communications, 2022 TRPV3 mediates cutaneous sensations such as itch and pain. Here authors present the cryo-EM structure of TRPV3 bound with local anesthetic which binds the channel in membrane portals that connect the membrane environment to the channel pore.
Arthur Neuberger +2 more
doaj +1 more source
Effects of dietary menthol-rich bioactive lipid compounds on zootechnical traits, blood variables and gastrointestinal function in growing sheep [PDF]
, 2019 Background The present study aimed at investigating the influence of 90% menthol-containing plant bioactive lipid compounds (PBLC, essential oils) on growth performance, blood haematological and biochemical profile, and nutrient absorption in sheep ...
Aschenbach, Jörg R. +9 more
core +1 more source
Identification of Natural Compound Carnosol as a Novel TRPA1 Receptor Agonist [PDF]
, 2014 The transient receptor potential ankyrin 1 (TRPA1) cation channel is one of the well-known targets for pain therapy. Herbal medicine is a rich source for new drugs and potentially useful therapeutic agents.
Li, Shiyou +6 more
core +3 more sources
Preventing a Perm with TRPV3 [PDF]
Cell, 2010 Epidermal growth factor receptor (EGFR) signaling is instrumental for terminal differentiation of keratinocytes, hair morphogenesis, and maintenance of the skin barrier. Cheng et al. (2010) now demonstrate that the calcium-permeable channel TRPV3 is required for these EGFR-dependent functions.
openaire +2 more sources
Thermoring basis for the TRPV3 bio-thermometer
Scientific Reports, 2023 Abstract The thermosensitive transient receptor potential (TRP) channels are well-known as bio-thermometers with specific temperature thresholds and sensitivity. However, their precise structural origins are still mysterious. Here, graph theory was used to test how the temperature-dependent non-covalent interactions as identified in ...
openaire +4 more sources
Quantitative Real-Time PCR Detection of TRPV1–4 Gene Expression in Human Leukocytes from Healthy and Hyposensitive Subjects [PDF]
, 2008 BACKGROUND: Besides functioning as chemosensors for a broad range of endogenous and synthetic ligands, transient receptor potential vanilloid (TRPV) 1-4 channels have also been related to capsaicin (TRPV1), pain, and thermal stimuli perception, and ...
Giacomo Spinsanti +7 more
core +1 more source
Targeting TRPV3 for the Development of Novel Analgesics [PDF]
The Open Pain Journal, 2013 Decades of characterization of the transient receptor potential vanilloid subtype 1 (TRPV1) have led to the realization of its central role in thermosensation and pain perception. A large number of pharmaceutical companies have had interest in developing TPRV1 antagonists for the treatment of pain.
Susan M, Huang, Man-Kyo, Chung
openaire +2 more sources
TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes
Communications Biology, 2023 Abstract Transient receptor potential vanilloid 3 (TRPV3) belongs to the TRP ion channel super family and functions as a nonselective cation channel that is highly permeable to calcium. This channel is strongly expressed in skin keratinocytes and is involved in warmth sensation, itch, wound healing and secretion of several cytokines ...
Yu Yamanoi +5 more
openaire +3 more sources