Results 21 to 30 of about 5,561 (208)
Temperature sensitive contact modes allosterically gate TRPV3
PLOS Computational Biology, 2023 TRPV Ion channels are sophisticated molecular sensors designed to respond to distinct temperature thresholds. The recent surge in cryo-EM structures has provided numerous insights into the structural rearrangements accompanying their opening and closing; however, the molecular mechanisms by which TRPV channels establish precise and robust temperature ...
Daniel Burns +2 more
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Evolution of vertebrate transient receptor potential vanilloid 3 channels: opposite temperature sensitivity between mammals and western clawed frogs. [PDF]
PLoS Genetics, 2011 Transient Receptor Potential (TRP) channels serve as temperature receptors in a wide variety of animals and must have played crucial roles in thermal adaptation.
Shigeru Saito +3 more
doaj +1 more source
MicroRNA-369 attenuates hypoxia-induced cardiomyocyte apoptosis and inflammation via targeting TRPV3 [PDF]
Brazilian Journal of Medical and Biological Research, 2021 Hypoxia-induced apoptosis and inflammation play an important role in cardiovascular diseases including myocardial infarction (MI). miR-369 has been suggested to be a key regulator of cardiac fibrosis.
Jinghao Wang, Xu Chen, Wei Huang
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Sensitization of Vanilloid Receptors TRPV3 [PDF]
Biophysical Journal, 2010 Vanilloid receptors of the transient receptor potential family have functions in thermal sensation and nociception. Among them, TRPV3 is expressed in skin keratinnocytes and has also been implicated in flavor sensation in oral and nasal cavities as well as being a molecular target of some allergens and skin sensitizers.
Liu, Beiying +3 more
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TRPV3 as a Therapeutic Target for Itch [PDF]
Journal of Investigative Dermatology, 2012 Abbreviations: AD, atopic dermatitis; AEW, acetone ether water; PGP9.5, protein gene product 9.5; TRPV3, transient receptor potential vanilloid subfamily ...
Yamamoto-Kasai, Erika +7 more
openaire +2 more sources
International Journal of Molecular Sciences, 2022 Itching is a sensory phenomenon characterized by an unpleasant sensation that makes you want to scratch the skin, and chronic itching diminishes the quality of life. In recent studies, multiple transient receptor potential (TRP) channels present in keratinocytes or nerve endings have been shown to engage in the propagation of itch signals in chronic ...
Ji Young Um +7 more
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Genes and primary headaches: discovering new potential therapeutic targets [PDF]
, 2013 Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors.
De Martino, Paola +8 more
core +3 more sources
Molecular Sensors and Modulators of Thermoreception [PDF]
, 2015 Peer ...
Zhang, Xuming
core +1 more source
The Basal Thermal Sensitivity of the TRPV1 Ion Channel Is Determined by PKCβII [PDF]
, 2014 Copyright © 2014 the authors 0270-6474/14/348246-13$15.00/0.Peer reviewedPublisher ...
Hasan, Raquibul, Li, Lin, Zhang, Xuming
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Journal of Pharmacy & Pharmaceutical Sciences, 2009 Transient receptor potential vanilloid-3 (TRPV3) is a thermo-sensitive ion channel expressed in skin keratinocytes and in a variety of neural cells. It is activated by warmth as well as monoterpenoids including camphor, menthol, dihydrocarveol and 1,8 ...
Muhammad Azhar Sherkheli +6 more
doaj +1 more source