Conformational ensemble of the human TRPV3 ion channel [PDF]
Nature Communications, 2018 Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists.
Lejla Zubcevic +7 more
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Pathogenesis and management of TRPV3-related Olmsted syndrome
Frontiers in GeneticsOlmsted syndrome is characterized by symmetrically distributed, destructive, inflammatory palmoplantar keratoderma with periorificial keratotic plaques, most commonly due to gain-of-function mutations in the transient receptor potential vanilloid 3 ...
Antong Lu +18 more
doaj +3 more sources
Structural dynamics and permeability of the TRPV3 pentamer
Nature CommunicationsTRPV3 belongs to the large superfamily of tetrameric transient receptor potential (TRP) ion channels. Recently, using high-speed atomic force microscopy (HS-AFM), we discovered a rare and transient pentameric state for TRPV3 that is in equilibrium with ...
Shifra Lansky +4 more
doaj +3 more sources
Enzymatically Hydrolyzed Eggshell Membrane Promotes Keratinocyte Differentiation Associated With PKC and Akt Signaling Pathways. [PDF]
J Food SciABSTRACT Skin aging is characterized by physiological and morphological changes, and nutritional interventions are key strategies to mitigate this process. Eggshell membrane (ESM), a natural byproduct of egg processing, is typically discarded as industrial waste; however, recent studies have revealed its health benefits, including antiobesity and anti ...
Furukawa K +5 more
europepmc +2 more sources
BRET-Based Approaches for Ion Channels: Emerging Applications and Future Directions. [PDF]
Arch Pharm (Weinheim)Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Kock N +6 more
europepmc +2 more sources
Epidermal PAR2-TRPV3-IL-33 Signaling Promotes Mast Cell Recruitment and Sensory Nerve-Mast Cell Interactions in Atopic Dermatitis. [PDF]
AllergyAllergy, Volume 81, Issue 5, Page 1898-1901, May 2026.
Zhao J +10 more
europepmc +2 more sources
Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice
Nature Communications, 2023 TRPV3, a non-selective cation transient receptor potential (TRP) ion channel, is activated by warm temperatures. It is predominantly expressed in skin keratinocytes, and participates in various somatic processes.
Jing Lei +5 more
doaj +1 more source
Monoterpenoid agonists of TRPV3 [PDF]
British Journal of Pharmacology, 2007 Background and purpose:Transient receptor potential (TRP) V3 is a thermosensitive ion channel expressed predominantly in the skin and neural tissues. It is activated by warmth and the monoterpene camphor and has been hypothesized to be involved in skin sensitization.
A K, Vogt-Eisele +6 more
openaire +2 more sources
Evolution of vertebrate transient receptor potential vanilloid 3 channels: opposite temperature sensitivity between mammals and western clawed frogs. [PDF]
PLoS Genetics, 2011 Transient Receptor Potential (TRP) channels serve as temperature receptors in a wide variety of animals and must have played crucial roles in thermal adaptation.
Shigeru Saito +3 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2022 Ischemic brain stroke is pathologically characterized by tissue acidosis, sustained calcium entry and progressive cell death. Previous studies focusing on antagonizing N-methyl-d-aspartate (NMDA) receptors have failed to translate any clinical benefits ...
Xiaoling Chen +2 more
doaj +1 more source