Structural dynamics and permeability of the TRPV3 pentamer [PDF]
Nature CommunicationsTRPV3 belongs to the large superfamily of tetrameric transient receptor potential (TRP) ion channels. Recently, using high-speed atomic force microscopy (HS-AFM), we discovered a rare and transient pentameric state for TRPV3 that is in equilibrium with ...
Shifra Lansky +4 more
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Molecular basis of TRPV3 channel blockade by intracellular polyamines [PDF]
Communications BiologyThermoTRPV1-4 channels are involved in the regulation of multiple physiological processes, including thermo- and pain perception, thermoregulation, itch, and nociception and therefore tight control of their activity is a critical requirement for correct ...
Jingying Zhang +3 more
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TRPV3 Channels Mediate Strontium-Induced Mouse-Egg Activation
Cell Reports, 2013 In mammals, calcium influx is required for oocyte maturation and egg activation. The molecular identities of the calcium-permeant channels that underlie the initiation of embryonic development are not established.
Ingrid Carvacho +3 more
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Conformational ensemble of the human TRPV3 ion channel [PDF]
Nature Communications, 2018 Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists.
Lejla Zubcevic +7 more
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Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action [PDF]
Nature CommunicationsOur skin safeguards the body homeostasis for health and also provides psychological consolation in social life. Natural essential oils are widely used for skin maintenance, while the molecular target and mechanism of action remain largely unknown.
Yang Li +14 more
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Erlotinib therapy for Olmsted syndrome with p.L655P missense mutation in the TRPV3 gene: a case report [PDF]
Frontiers in MedicineOlmsted syndrome (OS) is a rare disorder characterized by a mutilating palmoplantar keratoderma and periorificial keratotic plaques, but which shows considerable clinical heterogeneity. Recently, transient receptor potential vanilloid 3 (TRPV3) mutations
Jia Zhang +5 more
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Papillomavirus-like particles as vectors for ex vivo gene therapy of the skin [PDF]
Molecular Therapy: Nucleic AcidsEx vivo gene delivery to the skin utilizing retroviral vectors has been demonstrated to be a viable clinical option for replacement of defective genes.
Francesco Diversi +6 more
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Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine
eLife, 2021 The multimodal sensory channel transient receptor potential vanilloid-3 (TRPV3) is expressed in epidermal keratinocytes and implicated in chronic pruritus, allergy, and inflammation-related skin disorders.
Qiang Liu +12 more
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Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice
Nature Communications, 2023 TRPV3, a non-selective cation transient receptor potential (TRP) ion channel, is activated by warm temperatures. It is predominantly expressed in skin keratinocytes, and participates in various somatic processes.
Jing Lei +5 more
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Monoterpenoid agonists of TRPV3 [PDF]
British Journal of Pharmacology, 2007 Background and purpose:Transient receptor potential (TRP) V3 is a thermosensitive ion channel expressed predominantly in the skin and neural tissues. It is activated by warmth and the monoterpene camphor and has been hypothesized to be involved in skin sensitization.
A K, Vogt-Eisele +6 more
openaire +2 more sources