Results 31 to 40 of about 3,271 (166)
Acute heat-evoked temperature sensation is impaired but not abolished in mice lacking TRPV1 and TRPV3 channels. [PDF]
PLoS ONE, 2014 The discovery of heat-sensitive Transient Receptor Potential Vanilloid ion channels (ThermoTRPVs) greatly advanced our molecular understanding of acute and injury-evoked heat temperature sensation.
Irène Marics +4 more
doaj +1 more source
Abnormal Somatosensory Behaviors Associated With a Gain-of-Function Mutation in TRPV3 Channels
Frontiers in Molecular Neuroscience, 2022 Thermosensitive transient receptor potential V3 (TRPV3) is a polymodal receptor implicated in nociceptive, thermoceptive, pruritoceptive, and inflammatory pathways.
Mahar Fatima +8 more
doaj +1 more source
Targeting TRPV3 for the Development of Novel Analgesics [PDF]
The Open Pain Journal, 2013 Decades of characterization of the transient receptor potential vanilloid subtype 1 (TRPV1) have led to the realization of its central role in thermosensation and pain perception. A large number of pharmaceutical companies have had interest in developing TPRV1 antagonists for the treatment of pain.
Susan M, Huang, Man-Kyo, Chung
openaire +2 more sources
Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine
Nature Communications, 2022 TRPV3 mediates cutaneous sensations such as itch and pain. Here authors present the cryo-EM structure of TRPV3 bound with local anesthetic which binds the channel in membrane portals that connect the membrane environment to the channel pore.
Arthur Neuberger +2 more
doaj +1 more source
TRPV3 Channels Mediate Strontium-Induced Mouse-Egg Activation
Cell Reports, 2013 In mammals, calcium influx is required for oocyte maturation and egg activation. The molecular identities of the calcium-permeant channels that underlie the initiation of embryonic development are not established.
Ingrid Carvacho +3 more
doaj +1 more source
FRET analysis of the temperature-induced structural changes in human TRPV3
Scientific Reports, 2023 Transient receptor potential vanilloid member 3 (TRPV3) is an ion channel that plays a critical role in temperature sensing in skin. There have been active studies on how TRPV3, which is also known as one of the temperature-sensitive transient receptor ...
Jinyoung Kim +3 more
doaj +1 more source
Sensitization of Vanilloid Receptors TRPV3 [PDF]
Biophysical Journal, 2010 Vanilloid receptors of the transient receptor potential family have functions in thermal sensation and nociception. Among them, TRPV3 is expressed in skin keratinnocytes and has also been implicated in flavor sensation in oral and nasal cavities as well as being a molecular target of some allergens and skin sensitizers.
Liu, Beiying +3 more
openaire +1 more source
Advanced Science, EarlyView.Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan +13 more
wiley +1 more source
Channels, 2022 The transient receptor potential vanilloid (TRPV) family has been preliminarily discovered to play an important role in various cancers, including clear cell renal cell carcinoma (ccRCC), which is closely associated with immune infiltration. However, the
Zixuan Gong +6 more
doaj +1 more source
Gating of human TRPV3 in a lipid bilayer
Nature Structural & Molecular Biology, 2020 The transient receptor potential cation channel subfamily V member 3 (TRPV3) channel plays a critical role in skin physiology, and mutations in TRPV3 result in the development of a congenital skin disorder, Olmsted syndrome. Here we describe multiple cryo-electron microscopy structures of human TRPV3 reconstituted into lipid nanodiscs, representing ...
Zengqin Deng +6 more
openaire +3 more sources