The bovine TRPV3 as a pathway for the uptake of Na+, Ca2+, and NH4+ [PDF]
, 2018 Absorption of ammonia from the gastrointestinal tract results in problems that range from hepatic encephalopathy in humans to poor nitrogen efficiency of cattle with consequences for the global climate. Previous studies on epithelia and cells from the
Friederike, Stumpff +4 more
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Supercooling Agent Icilin Blocks a Warmth-Sensing Ion Channel TRPV3
The Scientific World Journal, 2012 Transient receptor potential vanilloid subtype 3 (TRPV3) is a thermosensitive ion channel expressed in a variety of neural cells and in keratinocytes. It is activated by warmth (33–39°C), and its responsiveness is dramatically increased at nociceptive ...
Muhammad Azhar Sherkheli +2 more
doaj +1 more source
Localization of TRPV3/4 and PIEZO1/2 sensory receptors in murine and human larynges
Laryngoscope Investigative Otolaryngology, 2022 Objective The primary aim of this study was to identify expression of TRPV3 and TRPV4 chemoreceptors across perinatal and adult stages using a murine model with direct comparisons to human laryngeal mucosa.
Alexander G. Foote +3 more
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Abnormal Somatosensory Behaviors Associated With a Gain-of-Function Mutation in TRPV3 Channels
Frontiers in Molecular Neuroscience, 2022 Thermosensitive transient receptor potential V3 (TRPV3) is a polymodal receptor implicated in nociceptive, thermoceptive, pruritoceptive, and inflammatory pathways.
Mahar Fatima +8 more
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Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins [PDF]
, 2018 Cold-inducible RNA-binding protein (CIRP), RNA-binding motif protein 3 (RBM3) and serine and arginine rich splicing factor 5 (SRSF5) are RNA-binding proteins that are transcriptionally upregulated in response to moderately low temperatures and a variety ...
Fujita Jun +7 more
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PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes [PDF]
Journal of Investigative Dermatology, 2020 Animal studies have suggested that transient receptor potential ion channels and G-protein coupled receptors play important roles in itch transmission. TRPV3 gain-of-function mutations have been identified in patients with Olmsted syndrome, which is associated with severe pruritus. However, the mechanisms causing itch remain poorly understood. Here, we
Jiahui Zhao +11 more
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TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation
Molecular Pain, 2011 Background The discovery of heat-sensitive Transient Receptor Potential Vanilloid (TRPV) ion channels provided a potential molecular explanation for the perception of innocuous and noxious heat stimuli.
Wang Juan +4 more
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A new TRPV3 missense mutation in a patient with Olmsted syndrome and erythromelalgia [PDF]
, 2014 IMPORTANCE: Olmsted syndrome (OS) is a rare keratinizing disorder characterized by excessive epidermal thickening of the palms and soles, with clinical and genetic heterogeneity.
Bodemer, Christine +7 more
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Acute heat-evoked temperature sensation is impaired but not abolished in mice lacking TRPV1 and TRPV3 channels. [PDF]
PLoS ONE, 2014 The discovery of heat-sensitive Transient Receptor Potential Vanilloid ion channels (ThermoTRPVs) greatly advanced our molecular understanding of acute and injury-evoked heat temperature sensation.
Irène Marics +4 more
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Frontiers in Immunology, 2022 BackgroundThe transient receptor potential vanilloid (TRPV) channels family, TRPV1-6, has been identified to profoundly affect a wide spectrum of pathological processes in various cancers. However, the biological function and prognostic value of TRPVs in
Yuxiong Jiang +8 more
doaj +1 more source