Results 1 to 10 of about 3,271 (166)
TRPV3: Structure, Diseases and Modulators
Molecules, 2023 Transient receptor potential vanillin 3 (TRPV3) is a member of the transient receptor potential (TRP) superfamily. As a Ca2+-permeable nonselective cation channel, TRPV3 can recognize thermal stimulation (31–39 °C), and it plays an important regulatory ...
Xuechuan Hong, Wuyue Su
exaly +5 more sources
TRPV3 in Drug Development [PDF]
Pharmaceuticals, 2016 Transient receptor potential vanilloid 3 (TRPV3) is a member of the TRP (Transient Receptor Potential) super-family. It is a relatively underexplored member of the thermo-TRP sub-family (Figure 1), however, genetic mutations and use of gene knock-outs ...
Adrian J Mogg +2 more
exaly +5 more sources
Orally available Colivin traps TRPV3 in an inactive state and suppresses intestinal inflammation [PDF]
The EMBO JournalTransient receptor potential vanilloid 3 (TRPV3) is a non-selective cation channel highly expressed in the skin and intestine. While its roles in itch and skin inflammation are established, the physiological role of TRPV3 in the intestine remains ...
Yujing Wang +13 more
doaj +2 more sources
Novel Insights into the Role of Keratinocytes-Expressed TRPV3 in the Skin
Biomolecules, 2023 TRPV3 is a non-selective cation channel that is highly expressed in keratinocytes in the skin. Traditionally, keratinocytes-expressed TRPV3 is involved in multiple physiological and pathological functions of the skin, such as itching, heat pain, and hair
Zhou Yu, Yaotao Guo
exaly +3 more sources
Avicularin and Senegenin Suppress TRPV3-Associated TSLP Expression in Human Keratinocytes [PDF]
CellsTransient receptor potential vanilloid channel 3 (TRPV3) is a keratinocyte-expressed ion channel that regulates calcium signaling and thymic stromal lymphopoietin (TSLP) production, contributing to pruritic inflammatory skin diseases. Although avicularin
Han Bi Kim +5 more
doaj +2 more sources
Acta Pharmaceutica Sinica B, 2022 Genetic gain-of-function mutations of warm temperature-sensitive transient receptor potential vanilloid 3 (TRPV3) channel cause Olmsted syndrome characterized by severe itching and keratoderma, indicating that pharmacological inhibition of TRPV3 may hold
KeWei Wang, Xiaoying Sun, Yuntao Shi
exaly +3 more sources
Temperature-dependent gating pathways in TRPV3 [PDF]
Scientific ReportsBoth hot and cold sensations of the homotetrameric thermosensitive transient receptor potential vanilloid 1–4 (TRPV1-4) channels have been predicted by a single Gibbs–Helmholtz equation for a change in molar heat capacity.
Guangyu Wang
doaj +2 more sources
TRPV3 channel activity helps cortical neurons stay active during fever [PDF]
eLifeFever raises body temperature (Tb) from ~37°C to beyond 38.4°C to combat pathogens. While generally well tolerated below 40°C, in rare cases, fever can abnormally elevate neural activity and induce seizures in neurotypical children aged 2–5 years.
Yiming Shen +4 more
doaj +2 more sources
Structural diversity of heat-sensing channel TRPV3 with Olmsted syndrome mutations [PDF]
Nature CommunicationsMutations in TRPV3, a temperature-sensitive ion channel critical for skin physiology, cause severe genodermatosis called Olmsted syndrome (OS). Here we integrate single-channel recordings and cryo-EM to characterize five OS mutants.
Jeffrey Khau +4 more
doaj +2 more sources
Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine
eLife, 2021 The multimodal sensory channel transient receptor potential vanilloid-3 (TRPV3) is expressed in epidermal keratinocytes and implicated in chronic pruritus, allergy, and inflammation-related skin disorders.
Qiang Liu +12 more
doaj +1 more source