Results 1 to 10 of about 5,561 (208)
TRPV3: Structure, Diseases and Modulators
Molecules, 2023 Transient receptor potential vanillin 3 (TRPV3) is a member of the transient receptor potential (TRP) superfamily. As a Ca2+-permeable nonselective cation channel, TRPV3 can recognize thermal stimulation (31–39 °C), and it plays an important regulatory ...
Wuyue Su, Xuechuan Hong
exaly +5 more sources
TRPV3 in Drug Development [PDF]
Pharmaceuticals, 2016 Transient receptor potential vanilloid 3 (TRPV3) is a member of the TRP (Transient Receptor Potential) super-family. It is a relatively underexplored member of the thermo-TRP sub-family (Figure 1), however, genetic mutations and use of gene knock-outs ...
Dominic L Li
exaly +5 more sources
Pathogenesis and management of TRPV3-related Olmsted syndrome [PDF]
Frontiers in GeneticsOlmsted syndrome is characterized by symmetrically distributed, destructive, inflammatory palmoplantar keratoderma with periorificial keratotic plaques, most commonly due to gain-of-function mutations in the transient receptor potential vanilloid 3 ...
Antong Lu +18 more
doaj +4 more sources
Novel Insights into the Role of Keratinocytes-Expressed TRPV3 in the Skin
Biomolecules, 2023 TRPV3 is a non-selective cation channel that is highly expressed in keratinocytes in the skin. Traditionally, keratinocytes-expressed TRPV3 is involved in multiple physiological and pathological functions of the skin, such as itching, heat pain, and hair
Zhou Yu
exaly +3 more sources
Acta Pharmaceutica Sinica B, 2022 Genetic gain-of-function mutations of warm temperature-sensitive transient receptor potential vanilloid 3 (TRPV3) channel cause Olmsted syndrome characterized by severe itching and keratoderma, indicating that pharmacological inhibition of TRPV3 may hold
Hang Qi, Yuntao Shi, Xiaoying Sun
exaly +3 more sources
Acta Pharmaceutica Sinica B, 2022 Ischemic brain stroke is pathologically characterized by tissue acidosis, sustained calcium entry and progressive cell death. Previous studies focusing on antagonizing N-methyl-d-aspartate (NMDA) receptors have failed to translate any clinical benefits ...
Xiaoling Chen +2 more
exaly +3 more sources
TRPV3 channel activity helps cortical neurons stay active during fever [PDF]
eLifeFever raises body temperature (Tb) from ~37°C to beyond 38.4°C to combat pathogens. While generally well tolerated below 40°C, in rare cases, fever can abnormally elevate neural activity and induce seizures in neurotypical children aged 2–5 years.
Yiming Shen +4 more
doaj +2 more sources
Repositioning Fluoxetine as a TRPV3 Channel Inhibitor to Alleviate Skin Inflammation and Pruritus [PDF]
Current Issues in Molecular BiologyTransient receptor potential vanilloid 3 (TRPV3) is a non-selective cation channel prominently present in the skin. It plays a role in diverse physiological and pathological functions like inflammation of the skin, pain sensations in the skin, and ...
Ling Zhang +4 more
doaj +2 more sources
Echinacoside Ameliorates UVB-Induced Skin Damage Through Selective Inhibition of the Cutaneous TRPV3 Channel [PDF]
MoleculesExcessive exposure to ultraviolet B (UVB) radiation can lead to skin damage, such as erythema and swelling. Echinacoside is a key effective ingredient of medicinal plant Cistanche deserticola commonly used for therapies and treatments for anti-aging and ...
Shilun Mo +5 more
doaj +2 more sources
The regulatory role and mechanism of TRPV3 on apoptosis and inflammation in osteoarthritis [PDF]
EXCLI Journal : Experimental and Clinical SciencesOsteoarthritis (OA) is one of the most common forms of degenerative joint disease characterized by persistent pain, inflammation of the joints, and restricted range of motion among the elderly worldwide.
Sahar Ghafari +2 more
doaj +2 more sources