Results 71 to 80 of about 2,492,447 (209)

Effect of Alpha-Glucosyl-Hesperidin Consumption on Lens Sclerosis and Presbyopia

Cells, 2021
Presbyopia is characterized by a decline in the ability to accommodate the lens. The most commonly accepted theory for the onset of presbyopia is an age-related increase in the stiffness of the lens.
Yosuke Nakazawa, Yuri Doki, Yuki Sugiyama, Ryota Kobayashi, Noriaki Nagai, Naoki Morisita, Shin Endo, Megumi Funakoshi-Tago, Hiroomi Tamura   +8 more
doaj   +1 more source

Quantitative Real-Time PCR Detection of TRPV1–4 Gene Expression in Human Leukocytes from Healthy and Hyposensitive Subjects [PDF]

, 2008
BACKGROUND: Besides functioning as chemosensors for a broad range of endogenous and synthetic ligands, transient receptor potential vanilloid (TRPV) 1-4 channels have also been related to capsaicin (TRPV1), pain, and thermal stimuli perception, and ...
Giacomo Spinsanti, Raffaella Zannolli, Cristina Panti, Ilaria Ceccarelli, Letizia Marsili, Valeria Bachiocco, Francesco Frati, Anna Maria Aloisi   +7 more
core   +1 more source

Differential expression and localization of thermosensitive Transient Receptor Potential Vanilloid (TRPV) channels in the mature sperm of white pekin duck (Anas platyrhynchos)

bioRxiv, 2020
Sperm cells have the ability of precise chemotactic and thermotactic movement which is crucial for fertilization, yet the key molecules involved in the detection of different chemical and physical stimuli and guide the sperm cells for proper navigation ...
R. Majhi, Ashutosh Kumar, Sunil C. Giri, C. Goswami   +3 more
semanticscholar   +1 more source

Inhibition of TRPV1 Channel Activity in Human CD4+ T Cells by Nanodiamond and Nanoplatinum Liquid, DPV576

Nanomaterials, 2018
Background: Transient receptor potential vanilloid (TRPV) channels act as sensors of pain, temperature, and other external stimuli. We have recently shown that DPV576, an aqueous mixture of nanodiamond (ND) and nanoplatinum (NP), can modulate the ...
Mamdooh H. Ghoneum, James K. Gimzewski, Aya Ghoneum, Hideki Katano, Clarissa Nila Paw U, Anshu Agrawal   +5 more
doaj   +1 more source

Atypical pharmacology of schistosome TRPA1-like ion channels. [PDF]

PLoS Neglected Tropical Diseases, 2018
Parasitic flatworms of the genus Schistosoma cause schistosomiasis, a neglected tropical disease estimated to affect over 200 million people worldwide.
Swarna Bais, Corbett T Berry, Xiaohong Liu, Gordon Ruthel, Bruce D Freedman, Robert M Greenberg   +5 more
doaj   +1 more source

Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor [PDF]

, 2017
Bone grafts are one of the most commonly transplanted tissues. However, autologous grafts are in short supply, and can be associated with pain and donor-site morbidity.
Biggs, Manus J. P., Blackburn, Gavin, Burgess, Karl, Childs, Peter G., Curtis, Adam S. G., Dalby, Matthew J., González-García, Cristina, Jayawarna, Vineetha, Orapiriyakul, Wich, Pemberton, Gabriel D., Reid, Stuart, Salmerón-Sánchez, Manuel, Thomas, Dilip, Tsimbouri, Penelope M., Vallejo-Giraldo, Catalina, Yang, Jingli   +15 more
core   +2 more sources

Mechanosensitivity of TRPV Channels: Implications for Vasopressin Neuron Activity

The FASEB Journal, 2020
Vasopressin is synthesised by magnocellular neurons in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei, and is secreted from the posterior pituitary gland in response to increased plasma osmolality.
Emily F. Brown, C. Brown, M. Fronius
semanticscholar   +1 more source

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

TRPV-mediated capsaicin-induced feeding promotion and growth enhancement in sea cucumber Apostichopus japonicus: First evidence in echinoderms

Aquaculture Reports
The transient receptor potential vanilloid (TRPV) subfamily plays crucial roles in sensory transduction and physiological regulation in mammals, yet its functional mechanisms remain poorly understood in marine invertebrates, particularly in echinoderms ...
Xuemin Wang, Yanlin Wang, Muyan Chen
doaj   +1 more source

TRP channels: Role in neurodegenerative diseases and therapeutic targets

Heliyon, 2023
TRP (Transient receptor potential) channels are integral membrane proteins consisting of a superfamily of cation channels that allow permeability of both monovalent and divalent cations. TRP channels are subdivided into six subfamilies: TRPC, TRPV, TRPM,
Mashoque Ahmad Rather, Andleeb Khan, Lianchun Wang, Sadaf Jahan, Muneeb U. Rehman, Hafiz A. Makeen, Syam Mohan   +6 more
doaj   +1 more source