Results 81 to 90 of about 2,492,447 (209)

Impacts of chronic stress on urinary bladder function & recovery through modification of PACAP signaling [PDF]

, 2016
Stress can cause or contribute to bladder dysfunction though specific effects remain unclear. Individuals with interstitial cystitis (IC)/bladder pain syndrome (BPS) experience increased symptom severity with stress, including pain and increased urgency ...
Mathews, Morgan E
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel. [PDF]

PLoS ONE, 2012
Angiotensin II (AngII) receptor (ATR) is involved in pathologic local events such as neovascularisation and inflammation including in the brain and retina.
Rene Barro-Soria, Julia Stindl, Claudia Müller, Renate Foeckler, Vladimir Todorov, Hayo Castrop, Olaf Strauß   +6 more
doaj   +1 more source

Thermosensation and the TRPV channel in Rhodnius prolixus

Journal of Insect Physiology, 2015
The thermal sense of triatomine bugs, vectors of Chagas disease, is unique among insects. Not only do these bugs exhibit the highest sensitivity to heat known in any animal up to date, but they can also perceive the infrared radiation emitted by the body of their warm-blooded hosts.
Zermoglio, Paula F., Latorre-Estivalis, Jose Manuel, Crespo, José E., Lorenzo, Marcelo Gustavo, Lazzari, Claudio R.   +4 more
openaire   +5 more sources

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice [PDF]

, 2017
The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated.
Chiurchiù, Valerio, Giustizieri, Michela, Leuti, Alessandro, Lombardi, Marta, Maccarrone, Mauro, Marinelli, Sara, Marinelli, Silvia, Marrone, Maria Cristina, Mattioli, Marzia, Morabito, Annunziato, Murana, Emanuele, Oddi, Sergio, Piomelli, Daniele, Ragozzino, Davide Antonio, Riganti, Loredana, Totaro, Antonio, Verderio, Claudia   +16 more
core   +3 more sources

Hell's Itch: A Self‐Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Hell's itch is a severely distressing dermatological condition characterized by the onset of incessant itching and intolerable pain 2–3 days post‐sunburn. It is underdiagnosed and underreported, and no definitive management framework has yet been developed.
Kai Peter Moors, Willem I. Visser
wiley   +1 more source

Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor

eLife, 2018
Although it has been known for over a decade that the inflammatory mediator NGF sensitizes pain-receptor neurons through increased trafficking of TRPV1 channels to the plasma membrane, the mechanism by which this occurs remains mysterious.
Anastasiia Stratiievska, Sara Nelson, Eric N Senning, Jonathan D Lautz, Stephen EP Smith, Sharona E Gordon   +5 more
doaj   +1 more source

Expression of transient receptor potential vanilloid (TRPV) channels in different passages of articular chondrocytes [PDF]

, 2012
Ion channels play important roles in chondrocyte mechanotransduction. The transient receptor potential vanilloid (TRPV) subfamily of ion channels consists of six members.
Barrett-Jolley, Richard, El-Shafei, Abdelrafea A., Hdud, Ismail M., Loughna, Paul, Mobasheri, Ali   +4 more
core   +3 more sources

Fluid Osmolarity Modulates the Rate of Spontaneous Contraction of Lymphatic Vessels and Lymph Flow by Means of a Cooperation between TRPV and VRAC Channels

Biology, 2023
Simple Summary The ability of lymphatic vessels to achieve lymph transport by exploiting external forces acting upon the vessels or by an intrinsic pumping mechanism based on spontaneous contractions of the vessel wall is vital for the physiological ...
E. Solari, C. Marcozzi, D. Negrini, A. Moriondo   +3 more
semanticscholar   +1 more source