Tranilast Does Not Inhibit TRPV2 [PDF]
CellsTransient receptor potential vanilloid 2 (TRPV2) is a non-selective cation channel involved in diverse physiological and pathological processes. Tranilast has frequently been described and used as a rather specific inhibitor of TRPV2.
Tabea C. Fricke +4 more
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TRPV2 mediates stress resilience in mouse cardiomyocytes [PDF]
Communications BiologyThe heart dynamically compensates for haemodynamic stress, but how this resilience forms during cardiac growth is not clear. Using a temporally inducible, cardiac-specific knockout in mice we show that the Transient receptor potential vanilloid family 2 (
Yubing Dong +8 more
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TRPV2 and TRPC5 are potential targets for astringent phytochemicals [PDF]
Current Research in Food ScienceAstringency is a multimodal sensory experience resulting from complex interactions between chemical compounds and the oral environment, involving tactile, chemosensory and thermosensory pathways.
Anna Kadkova +6 more
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Advanced Science, 2022 The transient receptor potential vanilloid 2 (TRPV2) channel is a nonselective cation channel that has been implicated in multiple sensory processes in the nervous system.
Bo Zhong
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TRPV2 in muscle satellite cells is crucial for skeletal muscle remodelling [PDF]
Cell Death and DiseaseSkeletal muscle remodelling relies on muscle stem cells (MuSCs) for regeneration after injury and hypertrophy in response to mechanical loading. However, the mechanisms that trigger MuSC activation and proliferation remain unclear.
Yanzhu Chen +8 more
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TRPV2 regulates cell fate in the human granulosa-like tumor cell line KGN: implications for granulosa cell tumors and cannabidiol [PDF]
Cell Communication and SignalingBackground The transient receptor potential vanilloid 2 (TRPV2) channel is known to have strong species-dependent activation modes and divers functions. Based on previous results, which showed expression by human ovarian granulosa cells, we studied human
Katja Eubler +14 more
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Upregulation of TRPV2 exacerbates age-related hearing loss by promoting oxidative stress in spiral ganglion neurons [PDF]
Molecular BrainAge-related hearing loss (ARHL) is a prevalent neurodegenerative condition characterized by the progressive loss of spiral ganglion neurons (SGNs). Although oxidative stress is recognized as a central pathogenic driver of ARHL, the precise molecular ...
Zhidong Zhang +11 more
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Characterization of TRPV2-associated pathology in Parkinson’s disease and therapeutic modulation using Tranilast [PDF]
Frontiers in Cellular NeuroscienceIntroductionTransient Receptor Potential (TRP) channels have gained worldwide attention for their expression and distribution in multiple human organs.
Apeksha Chunchuwar +2 more
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Structural origins of species-specific differences in TRPV2 activation [PDF]
Nature CommunicationsTransient receptor potential vanilloid 2 (TRPV2) is a broadly expressed ion channel implicated in diverse physiological and pathological processes. Despite strong conservation, human TRPV2 (hTRPV2) displays markedly reduced sensitivity to stimuli such as
Tabea C. Fricke +10 more
doaj +2 more sources
TRPV2 channels facilitate pulmonary endothelial barrier recovery after ROS-induced permeability [PDF]
Redox BiologyReactive oxygen species (ROS), such as hydrogen peroxide (H2O2), are known signaling molecules that increase endothelial barrier permeability. In this study, we investigated the roles of redox-sensitive transient receptor potential (TRP) ion channels ...
Lena Schaller +3 more
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