Results 11 to 20 of about 4,775 (199)
Molecular mechanism of TRPV2 channel modulation by cannabidiol [PDF]
eLife, 2019 Transient receptor potential vanilloid 2 (TRPV2) plays a critical role in neuronal development, cardiac function, immunity, and cancer. Cannabidiol (CBD), the non-psychotropic therapeutically active ingredient of Cannabis sativa, is an activator of TRPV2
Ruth A Pumroy +8 more
doaj +18 more sources
Engineering vanilloid-sensitivity into the rat TRPV2 channel [PDF]
eLife, 2016 The TRPV1 channel is a detector of noxious stimuli, including heat, acidosis, vanilloid compounds and lipids. The gating mechanisms of the related TRPV2 channel are poorly understood because selective high affinity ligands are not available, and the ...
Feng Zhang +8 more
doaj +4 more sources
Understanding the cellular function of TRPV2 channel through generation of specific monoclonal antibodies. [PDF]
PLoS ONE, 2013 Transient receptor potential vanilloid 2 (TRPV2) is a Ca(2+)-permeable nonselective cation channel proposed to play a critical role in a wide array of cellular processes.
Matthew R Cohen +3 more
doaj +2 more sources
TRPV2: A Cancer Biomarker and Potential Therapeutic Target [PDF]
Disease Markers, 2020 The Transient Receptor Potential Vanilloid type-2 (TRPV2) channel exhibits oncogenicity in different types of cancers. TRPV2 is implicated in signaling pathways that mediate cell survival, proliferation, and metastasis. In leukemia and bladder cancer, the oncogenic activity of TRPV2 was linked to alteration of its expression profile.
Kodappully S. Siveen +7 more
openaire +3 more sources
Structure of the Full-Length TRPV2 Channel by Cryo-EM [PDF]
Microscopy and Microanalysis, 2016 AbstractTransient receptor potential (TRP) proteins form a superfamily Ca2+-permeable cation channels regulated by a range of chemical and physical stimuli. Structural analysis of a ‘minimal’ TRP vanilloid subtype 1 (TRPV1) elucidated a mechanism of channel activation by agonists through changes in its outer pore region.
Huynh, Kevin W +6 more
openaire +8 more sources
Cannabidiol sensitizes TRPV2 channels to activation by 2-APB
eLife, 2023 The cation-permeable TRPV2 channel is important for cardiac and immune cell function. Cannabidiol (CBD), a non-psychoactive cannabinoid of clinical relevance, is one of the few molecules known to activate TRPV2.
Aaron Gochman +5 more
doaj +2 more sources
Scientific Reports, 2023 When orthodontic forces are applied to teeth, bone remodeling, which consists of bone resorption and bone formation, occurs around the teeth. Transient receptor potential vanilloid 2 (TRPV2) is a cation channel expressed in various cell types that ...
Shohei Shigemi +9 more
doaj +1 more source
Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel
eLife, 2022 Transient receptor potential vanilloid 2 (TRPV2) is a multimodal ion channel implicated in diverse physiopathological processes. Its important involvement in immune responses has been suggested such as in the macrophages’ phagocytosis process.
Xiaoyi Mo +12 more
doaj +1 more source
Flotillin-1 Interacts With and Sustains the Surface Levels of TRPV2 Channel
Frontiers in Cell and Developmental Biology, 2021 Transient receptor potential vanilloid subtype 2 (TRPV2) channel is a polymodal receptor regulating neuronal development, cardiac function, immunity and oncogenesis.
Juan Hu +9 more
doaj +1 more source
Physiologische Funktion und Modulation des TRPV2-Ionenkanals in Zellen des angeborenen Immunsystems [PDF]
, 2023 Obwohl der Ca2+ permeable Ionenkanal TRPV2 in zahlreichen Immunzellen exprimiert wird, ist wenig über seine physiologische Funktion bekannt. Bisherige Studien verließen sich größtenteils auf die Anwendung von unspezifischen Modulatoren, TRPV2-defizienten
Raudszus, Rick Paul
core +4 more sources