Results 21 to 30 of about 4,775 (199)

Expression and distribution of TRPV2 in rat brain [PDF]

Experimental Neurology, 2012
Transient receptor potential (TRP) proteins are non-selective cation channels that mediate sensory transduction. The neuroanatomical localization and the physiological roles of isoform TRPV2 in the rodent brain are largely unknown. We report here the neuroanatomical distribution of TRPV2 in the adult male rat brain focusing on the hypothalamus and ...
Thekkethil Prashant, Nedungadi, Mayurika, Dutta, Chandra Sekhar, Bathina, Michael J, Caterina, J Thomas, Cunningham   +4 more
openaire   +2 more sources

Cationic Channel TRPV2 Overexpression Promotes Resistance to Cisplatin-Induced Apoptosis in Gastric Cancer Cells

Frontiers in Pharmacology, 2021
Gastric cancer (GC) is characterized by poor efficacy and modest clinical impact of current therapies, in which apoptosis evasion is relevant. Intracellular calcium homeostasis dysregulation is associated with apoptosis escaping, and aberrant expression ...
Simona Laurino, Pellegrino Mazzone, Vitalba Ruggieri, Vitalba Ruggieri, Pietro Zoppoli, Giovanni Calice, Antonella Lapenta, Mario Ciuffi, Orazio Ignomirelli, Giulia Vita, Alessandro Sgambato, Sabino Russi, Geppino Falco, Geppino Falco   +13 more
doaj   +1 more source

TRPV2 knockout mice demonstrate an improved cardiac performance following myocardial infarction due to attenuated activity of peri-infarct macrophages. [PDF]

PLoS ONE, 2017
We have recently shown that the expression of the transient receptor potential vanilloid 2 channel, TRPV2, is upregulated in the peri-infarct zone 3-5 days following an acute myocardial infarction (AMI).
Michal Entin-Meer, Lena Cohen, Einat Hertzberg-Bigelman, Ran Levy, Jeremy Ben-Shoshan, Gad Keren   +5 more
doaj   +1 more source

Oxidation sensitizes TRPV2 to chemical and heat stimuli, but not mechanical stimulation

Biochemistry and Biophysics Reports, 2021
The transient receptor potential vanilloid 2 (TRPV2) ion channel is activated by a chemical ligand (2-aminoethoxydiphenyl borate; 2-APB), noxious heat and mechanical stimulation.
Mai Oda, Yuichiro Fujiwara, Yasuki Ishizaki, Koji Shibasaki   +3 more
doaj   +1 more source

transporter TRPV2 leads to pyroptotic cell death

, 2022
The enteropathogenic Escherichia coli (EPEC) type III secretion system effector Tir, which mediates intimate bacterial attachment to epithelial cells, also triggers Ca2+ influx followed by LPS entry and caspase-4-dependent pyroptosis, which could be ...
Jyoti S. Choudhary, Gad Frankel, Zhong, Q, Chatterjee, S, Sharanya Chatterjee, Choudhary, JS, Qiyun Zhong, Frankel, G   +7 more
core   +1 more source

TRPV2-induced Ca2+-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma

Cell Communication and Signaling, 2018
Background Myeloma bone disease (MBD) can cause bone destruction and increase the level of Ca2+ concentration in the bone marrow microenvironment by stimulating osteoclastic differentiation.
Hua Bai, Huayuan Zhu, Qing Yan, Xuxing Shen, Xiupan Lu, Juejin Wang, Jianyong Li, Lijuan Chen   +7 more
doaj   +1 more source

Role of transient receptor potential vanilloid subtype 2 in lower oesophageal sphincter in rat acid reflux oesophagitis

Journal of Pharmacological Sciences, 2021
Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder. In the present study, we investigated TRP vanilloid subfamily member 2 (TRPV2) expression in lower oesophageal sphincter (LES) and its involvement in acid reflux oesophagitis ...
Kenjiro Matsumoto, Minako Suenaga, Yumi Mizutani, Kohei Matsui, Ayano Yoshida, Tomohiro Nakamoto, Shinichi Kato   +6 more
doaj   +1 more source

Dystrophic cardiomyopathy: role of TRPV2 channels in stretch-induced cell damage [PDF]

, 2015
Aims Duchenne muscular dystrophy (DMD), a degenerative pathology of skeletal muscle, also induces cardiac failure and arrhythmias due to a mutation leading to the lack of the protein dystrophin.
Niggli, Ernst, Vögeli, Isabelle, Lorin, Charlotte   +2 more
core   +3 more sources

Oxidative Stress-Induced TRPV2 Expression Increase Is Involved in Diabetic Cataracts and Apoptosis of Lens Epithelial Cells in a High-Glucose Environment

Cells, 2022
Cataracts are a serious complication of diabetes. In long-term hyperglycemia, intracellular Ca2+ concentration ([Ca2+]i) and reactive oxygen species (ROS) are increased.
Linghui Chen, Yanzhuo Chen, Wen Ding, Tao Zhan, Jie Zhu, Lesha Zhang, Han Wang, Bing Shen, Yong Wang   +8 more
doaj   +1 more source

Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function

, 2022
TRPV2 is a ligand-operated temperature sensor with poorly defined pharmacology. Here, we combine calcium imaging and patch-clamp electrophysiology with cryo-electron microscopy (cryo-EM) to explore how TRPV2 activity is modulated by the phytocannabinoid ...
Zhang, Liying, Moparthi, Lavanya,, Gourdon, Pontus,, Nilsson, Gunnar,, Nilsson, Gunnar, Wang, Kaituo, Zygmunt, Peter M., Zimova, Lucie,, Hellmich, Ute A., Wang, Kaituo,, Simonsen, Charlotte, Zimova, Lucie, Gourdon, Pontus, Vlachova, Viktorie, Gaudet, Rachelle,, Vlachova, Viktorie,, Zhang, Liying,, Zygmunt, Peter M.,, Gaudet, Rachelle, Ekoff, Maria, Ekoff, Maria,, Hellmich, Ute A.,, Moparthi, Lavanya, Simonsen, Charlotte,   +23 more
core   +1 more source