Results 51 to 60 of about 804,478 (143)
TRPV channels in tumor growth and progression
, 2011 Transient receptor potential (TRP) channels affect several physiological and pathological processes. In particular, TRP channels have been recently involved in the triggering of enhanced proliferation, aberrant differentiation, and resistance to ...
AMANTINI, Consuelo +2 more
core +1 more source
Role of Transient Receptor Potential Vanilloid Channels (TRPV) in Cancer: Narrative Review [PDF]
, 2022 Cancer is the leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. It leads cancer to being a global problem. Cancer can modify calcium signaling networks by altering the expression and function of cation channels, pumps ...
HAIKAL, Muhamad Adly
core
Drosophila TRPN(=NOMPC) channel localizes to the distal end of mechanosensory cilia.
PLoS ONE, 2010 BackgroundA TRPN channel protein is essential for sensory transduction in insect mechanosensory neurons and in vertebrate hair cells. The Drosophila TRPN homolog, NOMPC, is required to generate mechanoreceptor potentials and currents in tactile bristles.
Jeongmi Lee +3 more
doaj +1 more source
Evidence for Novel Pharmacological Sensitivities of Transient Receptor Potential (TRP) Channels in Schistosoma mansoni. [PDF]
PLoS Neglected Tropical Diseases, 2015 Schistosomiasis, caused by parasitic flatworms of the genus Schistosoma, is a neglected tropical disease affecting hundreds of millions globally. Praziquantel (PZQ), the only drug currently available for treatment and control, is largely ineffective ...
Swarna Bais +3 more
doaj +1 more source
Role of Transient Receptor Potential Vanilloid Channels in Gastrointestinal Physiology and Pathology
ReceptorsTransient Receptor Potential Vanilloid (TRPV) channels represent one of the seven subfamilies of TRP receptors and are widely expressed throughout the human body where they play pivotal roles in various physiological processes.
Omar Tluli +7 more
doaj +1 more source
Advanced Science, EarlyView.B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu +4 more
wiley +1 more source
Distribution and Expression of Non-Neuronal Transient Receptor Potential (TRPV) Ion Channels in Rosacea [PDF]
, 2012 Rosacea is a frequent chronic inflammatory skin disease of unknown etiology. Because early rosacea reveals all characteristics of neurogenic inflammation, a central role of sensory nerves in its pathophysiology has been discussed.
Cevikbas, Ferda +10 more
core +1 more source
Aquaculture ReportsThe transient receptor potential vanilloid (TRPV) subfamily plays crucial roles in sensory transduction and physiological regulation in mammals, yet its functional mechanisms remain poorly understood in marine invertebrates, particularly in echinoderms ...
Xuemin Wang, Yanlin Wang, Muyan Chen
doaj +1 more source
An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Advanced Science, EarlyView.Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
Nanomaterials, 2018 Background: Transient receptor potential vanilloid (TRPV) channels act as sensors of pain, temperature, and other external stimuli. We have recently shown that DPV576, an aqueous mixture of nanodiamond (ND) and nanoplatinum (NP), can modulate the ...
Mamdooh H. Ghoneum +5 more
doaj +1 more source