Results 91 to 100 of about 7,490 (202)

A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin [PDF]

FEBS Letters, 1998
African trypanosomes contain a cytosolic serine oligopeptidase, called OP‐Tb, that is reversibly inhibited by the active principles of three of the five most commonly used trypanocidal drugs: pentamidine, diminazene and suramin. OP‐Tb was inhibited by pentamidine in a competitive manner, and by suramin in a partial, non‐competitive manner.
Morty, Rory E., Troeberg, Linda, Pike, Robert N., Jones, Roy, Nickel, Peter, Lonsdale-Eccles, John D., Coetzer, Theresa H.T.   +6 more
openaire   +2 more sources

Seasonal Dynamics and Associated Risk Factors of Bovine Trypanosomosis and Its Vector in Selected Districts of Gamo and Gofa Zones, Southern Ethiopia

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
The median PCV of poor body‐conditioned animals is below 20 (anaemic) compared to corresponding body‐condition animals. Black‐ and red‐coloured animals are more significantly affected by trypanosomosis than white‐coloured animals. Multivariable logistic regression revealed more about contributory factors than univariable logistic regression.
Solomon Mekuria, Aschenaki Kalsa
wiley   +1 more source

Short-course eflornithine in Gambian trypanosomiasis: a multicentre randomized controlled trial

Bulletin of the World Health Organization, 2000
OBJECTIVE: A randomized controlled trial was conducted to determine whether 7 days of intravenous eflornithine (100 mg/kg every 6 h) was as effective as the standard 14-day regimen in the treatment of late-stage Trypanosoma brucei gambiense ...
Jacques Pépin, Nzambi Khonde, Faustine Maiso, Félix Doua, Shabbar Jaffar, Stéphane Ngampo, Bokelo Mpia, Dawson Mbulamberi, Felix Kuzoe   +8 more
doaj  

Antiprotozoal Activity of Quinonemethide Triterpenes from Maytenus ilicifolia (Celastraceae)

Molecules, 2013
The present study describes the leishmanicidal and trypanocidal activities of two quinonemethide triterpenes, maytenin (1) and pristimerin (2), isolated from Maytenus ilicifolia root barks (Celastraceae).
Maysa Furlan, Ana Maria Soares Pereira, Regina M. B. Cicarelli, Beatriz S. Stolf, Mariana Kolos Galuppo, Camila T. Nogueira, Isabel Martinez, Luis O. Regasini, Mariana da Costa Siqueira, Karoline M. Leite, Vania A. F. F. M. dos Santos, Marcia A. S. Graminha   +11 more
doaj   +1 more source

Ethnomedical uses, chemical constituents, and evidence-based pharmacological properties of Chenopodium ambrosioides L.: extensive overview

Future Journal of Pharmaceutical Sciences, 2021
Background The Chenopodium genus is a plant family widely spread worldwide that includes various plant species reputed to possess several medicinal virtues in folk medicines. Chenopodium ambrosioides L.
Félicien Mushagalusa Kasali, Jonans Tusiimire, Justin Ntokamunda Kadima, Amon Ganafa Agaba   +3 more
doaj   +1 more source

A Clinical and Epidemiological Investigation of the First Reported Human Infection With the Zoonotic Parasite Trypanosoma evansi in Southeast Asia [PDF]

, 2016
Background. Trypanosoma is a genus of unicellular parasitic flagellate protozoa. Trypanosoma brucei species and Trypanosoma cruzi are the major agents of human trypanosomiasis; other Trypanosoma species can cause human disease, but are rare.
Baker, S, Berto, A, Campbell, JI, Carrique-Mas, J, Chalermwong, P, Desquesnes, M, Franco, JR, Herder, S, Jittapalapong, S, Le, BC, Nga, TVT, Ngo, TH, Ngo, TT, Nguyen, CT, Nguyen, KC, Nguyen, PHL, Nguyen, VC, Nguyen, VMH, Nguyen, VVC, Rabaa, MA, Tam, PTT, Thwaites, GE, Tran, TH, Wills, B, Yacoub, S, Yimming, B   +25 more
core   +1 more source

Antitrypanosomal Activity and Molecular Docking Studies of Lobetyolin From Lobelia rhynchopetalum Hemsl. Root Extract Against Trypanosoma congolense Field Isolates

BioMed Research International, Volume 2026, Issue 1, 2026.
Currently available drugs for trypanosomiasis are few, and their use is limited by toxicity and growing resistance. This highlights the need for safer and more effective alternatives. In this study, the in vitro and in vivo antitrypanosomal activities of an 80% methanol root extract of Lobelia rhynchopetalum and its major constituent were evaluated ...
Selamawit Yimer, Eyael Tewelde, Daniel Bisrat, Solomon Tadesse, Mariamawit Y. Yeshak, Rahul Shivahare   +5 more
wiley   +1 more source

Atypical human infections by animal trypanosomes: evaluation of human and animal trypanocidal drugs against Trypanosoma lewisi in Wistar rats [PDF]

, 2016
Trypanosomosis is a disease of medical and veterinary importance, mainly distributed in tropical areas of Africa, Latin America and Asia. Some Trypanosoma species are typically pathogenic for animals, such as Trypanosoma vivax, T. congolense, T.
Chalermwong, Piangjai, Desquesnes, Marc, Herder, Stéphane, Jittapalapong, Sathaporn, Yangtara, Sarawut   +4 more
core  

Field investigation of Trypanosoma evansi and comparative analysis of diagnostic tests in horses from Bahawalpur, Pakistan [PDF]

, 2017
In order to assess the prevalence of Trypanosoma evansi, a parasitological, molecular, and serological-based investigation was carried out in randomly sampled horses (n = 375) belonging to different age groups, sexes, and localities from the district of ...
Desquesnes, Marc, Jahan, Nusrat, Qamar, Muahammad Fiaz, Shahzad, Mirza Imran, Tehseen, Sonia   +4 more
core   +1 more source

Piplartine as an Innovative Natural Product With Dual Antiparasitic and Immunomodulatory Actions

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Neglected tropical diseases (NTDs) remain a major global health burden, disproportionately affecting low‐ and middle‐income regions and demanding innovative therapeutic strategies. This review summarizes current evidence on piplartine (piperlongumine), a naturally occurring amide from Piper species with broad antiparasitic and immunomodulatory ...
Lucas Fukui-Silva, Felipe C. R. de Souza, Camila S. Amorim, Josué de Moraes, Poorani Gurumallesh Prabu   +4 more
wiley   +1 more source