Results 91 to 100 of about 3,404 (180)

In Vivo Biological Evaluation of a Synthetic Royleanone Derivative as a Promising Fast-Acting Trypanocidal Agent by Inducing Mitochondrial-Dependent Necrosis [PDF]

, 2020
Rubén Martín‐Escolano, Juan J. Guardia, Javier Martín‐Escolano, Nuria Cirauqui, Antonio Fernández, María J. Rosales, Rachid Chahboun, Manuel Sánchez‐Moreno, Enrique Álvarez‐Manzaneda, Clotilde Marı́n   +9 more
openalex   +1 more source

The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi

Memorias do Instituto Oswaldo Cruz, 2010
Trypanosoma cruzi is a parasite that causes Chagas disease, which affects millions of individuals in endemic areas of Latin America. One hundred years after the discovery of Chagas disease, it is still considered a neglected illness because the available
Cristiane França da Silva, Patrícia Bernadino da Silva, Marcos Meuser Batista, Anissa Daliry, Richard R Tidwell, Maria de Nazaré Correia Soeiro   +5 more
doaj   +1 more source

Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and Trypanosoma cruzi Amastigotes

Pharmaceuticals
Background: Anticancer therapies represent the primary treatment option for a significant number of cancer patients globally; however, many of these treatments are associated with severe side effects as they target molecular structures present in both ...
Gabriela Alves de Souza, Lorrane de Souza Chaves, Afonso Santine M. M. Velez, Jorge Lucas F. Lacerda, Paulo Pitasse-Santos, Jayane Clys Conceição dos Santos, Otávio Augusto Chaves, Carlos Serpa, Raphael do Carmo Valente, Leonardo Marques da Fonseca , Marcos André Rodrigues da Costa Santos, Jhenifer Santos dos Reis, Carlos Antônio do Nascimento Santos, Lucia Mendonça-Previato, Jose Osvaldo Previato, Celio Geraldo Freire-de-Lima, Debora Decoté-Ricardo, Leonardo Freire-de-Lima, Marco Edilson Freire de Lima   +18 more
doaj   +1 more source

The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process.

PLoS ONE, 2015
Chagas' disease is an infection that is caused by the protozoan Trypanosoma cruzi, affecting millions of people worldwide. Because of severe side effects and variable efficacy, the current treatments for Chagas' disease are unsatisfactory, making the ...
Vânia Cristina Desoti, Danielle Lazarin-Bidóia, Fabianne Martins Ribeiro, Solange Cardoso Martins, Jean Henrique da Silva Rodrigues, Tania Ueda-Nakamura, Celso Vataru Nakamura, Valdecir Farias Ximenes, Sueli de Oliveira Silva   +8 more
doaj   +1 more source

A potent trypanocidal component from the fungus Lentinus strigosus inhibits trypanothione reductase and modulates PBMC proliferation

Memorias do Instituto Oswaldo Cruz, 2008
The fungus Lentinus strigosus (Pegler 1983) (Polyporaceae, basidiomycete) was selected in a screen for inhibitory activity on Trypanosoma cruzi trypanothione reductase (TR). The crude extract of L. strigosus was able to completely inhibit TR at 20 µg/ml.
Betania Barros Cota, Luiz Henrique Rosa, Elaine Maria Souza Fagundes, Olindo Assis Martins-Filho, Rodrigo Correa-Oliveira, Alvaro José Romanha, Carlos Augusto Rosa, Carlos Leomar Zani   +7 more
doaj   +1 more source

Evaluating 5-nitrothiazoles as trypanocidal agents

, 2013
s.r.wilkinson@qmul.ac ...
Bot, Christopher, Hall, Belinda S., Alvarez, Guzman, Di Maio, Rossanna, Gonzalez, Mercedes, Cerecetto, Hugo, Wilkinson, Shane R.   +6 more
openaire   +2 more sources

Carbohydrate‐binding agents act as potent trypanocidals that elicit modifications in VSG glycosylation and reduced virulence in Trypanosoma brucei [PDF]

, 2013
Víctor M. Castillo‐Acosta, Antonio E. Vidal, Luis M. Ruiz‐Pérez, Els J. M. Van Damme, Yasuhiro Igarashi, Jan Balzarini, Dolores González‐Pacanowska   +6 more
openalex   +1 more source

Identification of Potential Trypanosoma cruzi Trans-Sialidase Inhibitors by Computational Drug Repositioning Approaches

Scientia Pharmaceutica
Chagas disease, caused by the parasitic protozoan Trypanosoma cruzi (T. cruzi), represents a worldwide public health issue. To date, there is no efficient treatment to combat this pathology, and the only drugs available are usually toxic to the patient ...
Miguel A. Uc-Chuc, Nohemi Cigarroa-Toledo, Karla Y. Acosta-Viana, José I. Chan-Pérez, Juan C. Pineda-Cortes, Hernán de J. Villanueva-Alonzo   +5 more
doaj   +1 more source

[Introduction of changes in the DNA of Trypanosoma cruzi by trypanocidal agents].

Revista Argentina de microbiologia, 1989
Incubation of Trypanosoma cruzi culture (epimastigote) forms with nifurtimox (10 or 100 microM), benznidazole (38 or 380 microM) and beta-lapachone (1.6 or 7.8 microM) produced damage of nuclear DNA, as shown by the increased rate of the "unscheduled DNA synthesis" in epimastigotes arrested at phase S (9-, 3-, and 6-fold, respectively). alpha-lapachone,
S G, Goijman, A C, Frasch, A O, Stoppani
openaire   +1 more source

Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents

, 2001
Zhili Li, Michael W. Fennie, Bruce Ganem, Matthew T Hancock, Muris Kobašlija, Donna Rattendi, Cyrus J. Bacchi, Mary C. O’Sullivan   +7 more
openalex   +1 more source