Results 111 to 120 of about 7,490 (202)

Novel cruzain inhibitors for the treatment of Chagas' disease. [PDF]

, 2012
The protozoan parasite Trypanosoma cruzi, the etiological agent of Chagas' disease, affects millions of individuals and continues to be an important global health concern.
Arkin, Michelle R, Doak, Allison, Durrant, Jacob D, Keränen, Henrik, McCammon, J Andrew, Ratnam, Joseline, Rogers, Kathleen E   +6 more
core   +1 more source

The trypanocidal activity of the alkaloid oliverine involves inhibition of DNA synthesis [PDF]

, 2010
The Trypanosoma cruzi parasite is an etiologic agent of the American trypanosomiasis called Chagas disease. This pathology affects more than 24 million persons and represents one of the most important public health problems in Latin America.
Garro, Hugo Alejandro, Juri Ayub, Maximiliano, Lucero Estrada, Cecilia Stella Marys, Nieto, M., Pungitore, Carlos Rodolfo, Tonn, Carlos Eugenio   +5 more
core  

Trypanocidal activity of the proteasome inhibitor and anti-cancer drug bortezomib [PDF]

, 2009
The proteasome inhibitor and anti-cancer drug bortezomib was tested for in vitro activity against bloodstream forms of Trypanosoma brucei. The concentrations of bortezomib required to reduce the growth rate by 50% and to kill all trypanosomes were 3.3 nM
Steverding Dietmar, Wang Xia
core   +2 more sources

Insights into Chagas treatment based on the potential of bacteriocin AS-48

International Journal for Parasitology: Drugs and Drug Resistance, 2019
Chagas disease caused by the protozoan parasite Trypanosoma cruzi represents a significant public health problem in Latin America, affecting around 8 million cases worldwide.
Rubén Martín-Escolano, Rubén Cebrián, Javier Martín-Escolano, Maria J. Rosales, Mercedes Maqueda, Manuel Sánchez-Moreno, Clotilde Marín   +6 more
doaj   +1 more source

Chagas' disease: an update on immune mechanisms and therapeutic strategies [PDF]

, 2010
The final decade of the 20th century was marked by an alarming resurgence in infectious diseases caused by tropical parasites belonging to the kinetoplastid protozoan order.
Abel, Abrahamsohn, Abrahamsohn, Albareda, Almeida, Alvarez, Alves, Araujo, Bafica, Bahia-Oliveira, Barr, Benvenuti, Bilate, Bixby, Bodley, Bonney, Boscardin, Bustamante, Bustamante, Cabeza Meckert, Caldas, Campos, Campos, Cardillo, Castanos-Velez, Cazzulo, Chamond, Cunha-Neto, Da Silva, Diez, Docampo, Duschak, Duthie, Dutra, Dutra, Engel, Esteva, Fonseca, Fonseca, Frank, Frank, Fuenmayor, Galvao Da Silva, Garg, Gattuso, Gomes, Gonzales-Perdomo, Hardison, Hardison, Higuchi, Hoft, Holscher, Hunter, Hyland, Kierszenbaum, Koga, Kotner, Krettli, Krettli, Kroll-Palhares, Kumar, Lages-Silva, Lages-Silva, Laucella, Lelchuk, Lelchuk, Lieke, Lima-Martins, Machado, Machado, Magdaleno, Manarin, Marin-Neto, Marinho, Martin, Maya, Michailowsky, Michailowsky, Moncayo, Muller, Murta, Nomizo, Okabe, Olivieri, Pascutti, Paveto, Piaggio, Piaggio, Punukollu, Reis, Revelli, Ribeirao, Rivarola, Rodrigues, Rodriques Coura, Romanha, Rottenberg, Rottenberg, Rottenberg, Rowland, Sales, Sanchez-Burgos, Santos Lima, Sathler-Avelar, Sathler-Avelar, Shoda, Soares, Souza, Stephens, Stolf, Stolić, Takeda, Talvani, Talvani, Tarleton, Tarleton, Tarleton, Tzelepis, Tzelepis, Tzelepis, Urbina, Urbina, Vaidian, Vasconcelos, Vitelli-Avelar, Walker   +125 more
core   +1 more source

Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease

Frontiers in Pharmacology, 2019
Leishmaniasis and Chagas disease cause great impact on social and economic aspects of people living in developing countries. The treatments for these diseases are based on the same regimen for over 40 years, thus, there is an urgent need for the ...
Roberval Nascimento Moraes Neto, Ruth Flávia Barros Setúbal, Taciana Mirely Maciel Higino, Maria Carolina Accioly Brelaz-de-Castro, Luís Cláudio Nascimento da Silva, Amanda Silva dos Santos Aliança   +5 more
doaj   +1 more source

Ligand-Based Virtual Screening and Molecular Docking of Benzimidazoles as Potential Inhibitors of Triosephosphate Isomerase Identified New Trypanocidal Agents. [PDF]

Int J Mol Sci, 2022
Vázquez-Jiménez LK, Juárez-Saldivar A, Gómez-Escobedo R, Delgado-Maldonado T, Méndez-Álvarez D, Palos I, Bandyopadhyay D, Gaona-Lopez C, Ortiz-Pérez E, Nogueda-Torres B, Ramírez-Moreno E, Rivera G.   +11 more
europepmc   +1 more source

The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi

Memorias do Instituto Oswaldo Cruz, 2010
Trypanosoma cruzi is a parasite that causes Chagas disease, which affects millions of individuals in endemic areas of Latin America. One hundred years after the discovery of Chagas disease, it is still considered a neglected illness because the available
Cristiane França da Silva, Patrícia Bernadino da Silva, Marcos Meuser Batista, Anissa Daliry, Richard R Tidwell, Maria de Nazaré Correia Soeiro   +5 more
doaj   +1 more source

Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and Trypanosoma cruzi Amastigotes

Pharmaceuticals
Background: Anticancer therapies represent the primary treatment option for a significant number of cancer patients globally; however, many of these treatments are associated with severe side effects as they target molecular structures present in both ...
Gabriela Alves de Souza, Lorrane de Souza Chaves, Afonso Santine M. M. Velez, Jorge Lucas F. Lacerda, Paulo Pitasse-Santos, Jayane Clys Conceição dos Santos, Otávio Augusto Chaves, Carlos Serpa, Raphael do Carmo Valente, Leonardo Marques da Fonseca , Marcos André Rodrigues da Costa Santos, Jhenifer Santos dos Reis, Carlos Antônio do Nascimento Santos, Lucia Mendonça-Previato, Jose Osvaldo Previato, Celio Geraldo Freire-de-Lima, Debora Decoté-Ricardo, Leonardo Freire-de-Lima, Marco Edilson Freire de Lima   +18 more
doaj   +1 more source

The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process.

PLoS ONE, 2015
Chagas' disease is an infection that is caused by the protozoan Trypanosoma cruzi, affecting millions of people worldwide. Because of severe side effects and variable efficacy, the current treatments for Chagas' disease are unsatisfactory, making the ...
Vânia Cristina Desoti, Danielle Lazarin-Bidóia, Fabianne Martins Ribeiro, Solange Cardoso Martins, Jean Henrique da Silva Rodrigues, Tania Ueda-Nakamura, Celso Vataru Nakamura, Valdecir Farias Ximenes, Sueli de Oliveira Silva   +8 more
doaj   +1 more source