Results 21 to 30 of about 7,490 (202)

Terpenoid Derivatives as Potential Trypanocidal Agents [PDF]

Medicinal chemistry, 2016
In this review we refer to a promising family of molecules in the fight against Chagas disease. Terpene derivatives are abundant in the plant Kingdom and in the last years many compounds have shown important biological activities. Diterpenes and sesquiterpene lactones have shown in vitro and in vivo trypanocidal activity and they emerge as potential ...
Lozano E, Barrera P
openaire   +3 more sources

Electrocardiographic Abnormalities and Treatment with Benznidazole among Children with Chronic Infection by Trypanosoma cruzi: A Retrospective Cohort Study [PDF]

, 2016
Background: Chronic infection by Trypanosoma cruzi could cause heart conduction disturbances. We sought to analyze electrocardiographic abnormalities among children with chronic T. cruzi infection with and without trypanocidal treatment with benznidazole.
Colantonio, Lisandro Damián, Prado, Nilda, Segura, Elsa Leonor, Sosa-Estani, Sergio Alejandro   +3 more
core   +15 more sources

Synthesis of 4-(4-chlorophenyl)thiazole compounds: in silico and in vitro evaluations as leishmanicidal and trypanocidal agents [PDF]

Anais da Academia Brasileira de Ciências, 2023
Neglected tropical diseases are a diverse group of communicable pathologies that mainly prevail in tropical and subtropical regions. Thus, the objective of this work was to evaluate the biological potential of eight 4-(4-chlorophenyl)thiazole compounds ...
IRANILDO JOSÉ DA CRUZ FILHO, JAMERSON F. DE OLIVEIRA, ALINE CAROLINE S. SANTOS, VALÉRIA R.A. PEREIRA, MARIA CARMO A. DE LIMA   +4 more
doaj   +1 more source

Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen

Frontiers in Tropical Diseases, 2023
The repurposing of approved drugs is an appealing method to fast-track the development of novel therapies for neglected diseases. Amiodarone and dronedarone, two approved antiarrhythmic agents, have been reported to have potential for the management of ...
Amanda F. Francisco, Gong Chen, Wen Wang, Melissa L. Sykes, Fanny Escudié, Ivan Scandale, Francisco Olmo, David M. Shackleford, Bilal Zulfiqar, Jadel M. Kratz, Thao Pham, Jessica Saunders, Meiyu Hu, Vicky M. Avery, Susan A. Charman, John M. Kelly, Eric Chatelain   +16 more
doaj   +1 more source

Lipophilic Guanylhydrazone Analogues as Promising Trypanocidal Agents: An Extended SAR Study [PDF]

Current Pharmaceutical Design, 2020
In this report, we extend the SAR analysis of a number of lipophilic guanylhydrazone analogues with respect to in vitro growth inhibition of Trypanosoma brucei and Trypanosoma cruzi. Sleeping sickness and Chagas disease, caused by the tropical parasites T. brucei and T.
Vasiliki Pardali, Erofili Giannakopoulou, Dimitrios-Ilias Balourdas, Vassilios Myrianthopoulos, Martin C. Taylor, Marina Šekutor, Kata Mlinarić-Majerski, John M. Kelly, Grigoris Zoidis   +8 more
openaire   +3 more sources

Anti-protozoal activity and metabolomic analyses of Cichorium intybus L. against Trypanosoma cruzi

International Journal for Parasitology: Drugs and Drug Resistance, 2022
Chagas disease, caused by the protozoa Trypanosoma cruzi, is a potentially life-threatening parasitic zoonosis infecting 6–7 million people worldwide, mainly in Latin America.
Miguel Peña-Espinoza, Yeambell Romero-Uzqueda, Angela H. Valente, Matthew de Roode, Henrik T. Simonsen, Stig M. Thamsborg, Andrew R. Williams, Rodrigo López-Muñoz   +7 more
doaj   +1 more source

Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents. [PDF]

Chembiochem
All‐cis‐fluorinated cyclohexyl motifs with progressively increasing levels of fluorine are introduced into the WKYMVm peptide and a class of keto‐piperazine derivatives and assayed against the FPR2 receptor or the parasite Trypanosoma brucei, respectively.
He M, Thomson CM, Thompson D, Kuodis V, Smith TK, Dall'Angelo S, O'Hagan D.   +6 more
europepmc   +2 more sources

Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids [PDF]

, 2020
This is the pre-peer reviewed version of the following article: Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids, which has been published in final form at https://doi.org/10.1002/slct.201903835.
Carda, Miguel, Cardona G, Wilson I, Coa, Juan Carlos, Conesa Milián, Laura, Robledo, Sara M., Upegui Zapata, Yulieth Alexandra, Yepes, Andrés   +6 more
core   +1 more source

Natural Sesquiterpene Lactones as Potential Trypanocidal Therapeutic Agents: A Review [PDF]

Natural Product Communications, 2016
Chagas’ disease and Human African Trypanosomiasis are parasitic diseases that remain major health problems, mainly among the poorest and the most marginalized communities from Latin America and Africa. The scarcity of effective chemotherapy, due to the low investment in the research and development (R&D) of new drugs, together with a high ...
Liliana V, Muschietti, Jerónimo L, Ulloa   +1 more
openaire   +2 more sources

Ruthenium-Catalyzed CH Alkenylation of Trypanocidal Naphthoquinones: A Mechanistic Benchmarking Study. [PDF]

ChemistryOpen
Computational roadmap to click‐ready quinones. Quantum chemical analysis reveals how substituents modulate the reactivity of trypanocidal naphthoquinones in Ru‐catalyzed CH alkenylation, guiding the design of sulfonyl‐fluoride scaffolds for next‐generation antiparasitic agents.
Paz ERS, Souza CP, De Oliveira JC, Almeida RG, Herrera-Acevedo C, Lakoh S, Jardim GAM, da Silva Júnior EN, Fantuzzi F.   +8 more
europepmc   +2 more sources