Gossypol: a potential trypanocidal agent [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 1985 Antonio Blanco
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Synthesis of New Trypanocidal Agents from the Hybridisation of Metronidazole and Eugenol Analogues
Bioorganic Chemistry, 2023 Nitroimidazole compounds are well-known bioactive substances, and the structural activity relationship has been reported whereby the position of the nitro group within the imidazole ring has a large influence on the activity. This study focuses on synthesising new trypanocidal agents from the hybridisation of metronidazole with different natural ...
Lucas Lopardi Franco +12 more
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Pilot-Scale Compound Screening against RNA Editing Identifies Trypanocidal Agents [PDF]
SLAS Discovery, 2014 Most mitochondrial messenger RNAs in trypanosomatid pathogens undergo a unique type of posttranscriptional modification involving insertion and/or deletion of uridylates. This process, RNA editing, is catalyzed by a multiprotein complex (~1.6 MDa), the editosome.
Houtan Moshiri +3 more
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Trypanocidal Effects of Polyprenylated Benzophenone Enriched Brazilian Red Propolis Extract and Its Isolated Constituent. [PDF]
Chem BiodiversIn vitro trypanocidal activity of a polyprenylated benzophenone‐enriched Brazilian red propolis extract (SEBz) and its major constituents, guttiferone E/xanthochymol (GUT/XAN) and oblongifolin B (OBL), exhibit in vitro trypanocidal activity against Trypanosoma cruzi, inducing ultrastructural damage with moderate cytotoxicity and no significant ...
Oliveira ND +9 more
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Synthesis of indazol‐4,7‐dione derivatives as potential trypanocidal agents
Journal of Heterocyclic Chemistry, 2002 AbstractThe synthesis of new indazol‐4,7‐dione derivatives via 1,3‐dipolar cycloaddition of diazomethane with 2,3‐dimethyl‐1,4‐benzoquinone (2) and 1,4‐naphthoquinone (7) followed by N‐alkylation of the pyrazol nitrogen atom of the corresponding quinones (3) and (8) with methyl chloroacetate is described.
Ricardo A. Tapia +6 more
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SYNTHESIS OF 4-ALKYLAMINO-6-CHLOROQUINOLINES AS POTENTIAL TRYPANOCIDAL AGENTS [PDF]
Heterocyclic Communications, 2002 Ricardo A. Tapia +6 more
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Natural Sesquiterpene Lactones as Potential Trypanocidal Therapeutic Agents: A Review [PDF]
Natural Product Communications, 2016 Chagas’ disease and Human African Trypanosomiasis are parasitic diseases that remain major health problems, mainly among the poorest and the most marginalized communities from Latin America and Africa. The scarcity of effective chemotherapy, due to the low investment in the research and development (R&D) of new drugs, together with a high ...
Liliana Muschietti, Jerónimo Ulloa
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DB75, a Novel Trypanocidal Agent, Disrupts Mitochondrial Function in Saccharomyces cerevisiae [PDF]
Antimicrobial Agents and Chemotherapy, 2004 ABSTRACT The aromatic diamidines represent a class of compounds with broad-spectrum antimicrobial activity; however, their development is hindered by a lack of understanding of their mechanism of antimicrobial action. DB75 [2,5-bis(4-amidinophenyl)furan] is a trypanocidal aromatic diamidine that was originally developed as a ...
Charlotte Lanteri +3 more
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Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents. [PDF]
ChembiochemAll‐cis‐fluorinated cyclohexyl motifs with progressively increasing levels of fluorine are introduced into the WKYMVm peptide and a class of keto‐piperazine derivatives and assayed against the FPR2 receptor or the parasite Trypanosoma brucei, respectively.
He M +6 more
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Synthesis and Biological Evaluation of Tetrahydroisoquinoline Derivatives as Trypanocidal Agents
ACS OmegaJoão Paulo de Moura Lopes +9 more
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