Results 31 to 40 of about 3,404 (180)

The trans-Sialidase from Trypanosoma cruzi a Putative Target for Trypanocidal Agents [PDF]

The Open Parasitology Journal, 2010
Trypanosomatid protozoa are parasites of considerable medical and economical importance because they are the causative agents of chronic human and livestock diseases endemic in developing countries. Trypanosoma cruzi is the causative agent of Chagas´ disease, present in most of Latin America. The biology of this parasite presents some unusual features,
Lúcia Mendonça‐Previato, Adriane Regina Todeschini, Leonardo Freire de Lima, Jose Osvaldo Previato   +3 more
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Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen

Frontiers in Tropical Diseases, 2023
The repurposing of approved drugs is an appealing method to fast-track the development of novel therapies for neglected diseases. Amiodarone and dronedarone, two approved antiarrhythmic agents, have been reported to have potential for the management of ...
Amanda F. Francisco, Gong Chen, Wen Wang, Melissa L. Sykes, Fanny Escudié, Ivan Scandale, Francisco Olmo, David M. Shackleford, Bilal Zulfiqar, Jadel M. Kratz, Thao Pham, Jessica Saunders, Meiyu Hu, Vicky M. Avery, Susan A. Charman, John M. Kelly, Eric Chatelain   +16 more
doaj   +1 more source

Intravenous liposomal benznidazole as trypanocidal agent: increasing drug delivery to liver is not enough [PDF]

International Journal of Pharmaceutics, 2004
With the aim of investigating if delivery of benznidazole (BNZ) to liver could be increased by incorporating the drug in multilamellar liposomes, single bolus of free BNZ or liposomal BNZ formulations (MLV-BNZ) composed of HSPC:DSPG:Chol 2:1:2 (mol/mol/mol) at 0.7% (w/w) drug/total lipid ratio, were injected by intramuscular (i.m.), subcutaneous (s.c.)
María José Morilla, Jorge Montanari, María Jimena Prieto, M.O Lopez, Patricia B. Petray, Eder Lilia Romero   +5 more
openalex   +4 more sources

Huprines as a new family of dual acting trypanocidal–antiplasmodial agents [PDF]

Bioorganic & Medicinal Chemistry, 2011
A series of 19 huprines has been evaluated for their activity against cultured bloodstream forms of Trypanosoma brucei and Plasmodium falciparum. Moreover, cytotoxicity against rat myoblast L6 cells was assessed for selected huprines. All the tested huprines are moderately potent and selective trypanocidal agents, exhibiting IC(50) values against T ...
Julien Defaux, Marta Sala, X. Formosa, Carles Galdeano, Martin C. Taylor, Waleed A Alobaid, John M. Kelly, Colin W. Wright, Pelayo Camps, Diego Muñoz‐Torrero   +9 more
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Lipophilic Guanylhydrazone Analogues as Promising Trypanocidal Agents: An Extended SAR Study [PDF]

Current Pharmaceutical Design, 2020
In this report, we extend the SAR analysis of a number of lipophilic guanylhydrazone analogues with respect to in vitro growth inhibition of Trypanosoma brucei and Trypanosoma cruzi. Sleeping sickness and Chagas disease, caused by the tropical parasites T. brucei and T.
Vasiliki Pardali, Erofili Giannakopoulou, Dimitrios-Ilias Balourdas, Vassilios Myrianthopoulos, Martin C. Taylor, Marina Šekutor, Kata Mlinarić-Majerski, John M. Kelly, Grigoris Zoidis   +8 more
openaire   +3 more sources

Synthesis of New Isoxazolylnaphthoquinones as Potential Trypanocidal and Antibacterial Agents [PDF]

Journal of Chemical Research, 1999
The synthesis of three new isoxazolylnaphthoquinones with an ethyl group on the isoxazole ring is reported.
Gladys E. Granero, M. M. de Bertorello, Margarita C. Briñón   +2 more
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Synthesis of Novel Acetamidobenzanilides Derivatives as Potencial Trypanocidal Agents [PDF]

Abstract A simple synthesis of novel N-(2-[N’-acetamidomethyl])benzanilides derivatives from 2-nitrobenzaldehyde in a four steps process is described. The 1H-NMR and 13C-NMR spectra were meticulously analyzed to characterize their structure and it was observed that derivatives with an ortho-substituted phenyl group exhibited detectable ...
Valentín I. Ortellado, Carlos Ulises Molfesa Kaczoruk, Lucio Agustin Guaymas, Ezequiel Parisi, Guido G. Fraga, Gisela C. Muscia, Fernanda M. Frank, Ana M. Bruno, Agustı́n Ponzinibbio, Leandro D. Sasiambarrena   +9 more
openalex   +2 more sources

Anti-protozoal activity and metabolomic analyses of Cichorium intybus L. against Trypanosoma cruzi

International Journal for Parasitology: Drugs and Drug Resistance, 2022
Chagas disease, caused by the protozoa Trypanosoma cruzi, is a potentially life-threatening parasitic zoonosis infecting 6–7 million people worldwide, mainly in Latin America.
Miguel Peña-Espinoza, Yeambell Romero-Uzqueda, Angela H. Valente, Matthew de Roode, Henrik T. Simonsen, Stig M. Thamsborg, Andrew R. Williams, Rodrigo López-Muñoz   +7 more
doaj   +1 more source

Natural and Semisynthetic Analogues of Manadoperoxide B Reveal New Structural Requirements for Trypanocidal Activity

Marine Drugs, 2013
Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3).
Orazio Taglialatela-Scafati, Deniz Tasdemir, Marcel Kaiser, Henny A. Dien, Barbara Calcinai, Carlo Cerrano, Fernando Scala, Giuseppina Chianese   +7 more
doaj   +1 more source

Trypanocidal Activity of Quinoxaline 1,4 Di-N-oxide Derivatives as Trypanothione Reductase Inhibitors

Molecules, 2017
Chagas disease or American trypanosomiasis is a worldwide public health problem. In this work, we evaluated 26 new propyl and isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives as potential trypanocidal agents. Additionally, molecular docking
Karla Fabiola Chacón-Vargas, Benjamin Nogueda-Torres, Luvia E. Sánchez-Torres, Erick Suarez-Contreras, Juan Carlos Villalobos-Rocha, Yuridia Torres-Martinez, Edgar E. Lara-Ramirez, Giulia Fiorani, R. Luise Krauth-Siegel, Maria Laura Bolognesi, Antonio Monge, Gildardo Rivera   +11 more
doaj   +1 more source