Results 61 to 70 of about 3,404 (180)

Biosafety Evaluation of 6,7‐Dihydroxy‐3‐(2‐Nitrophenyl)Coumarin in Human Cells

Journal of Applied Toxicology, Volume 46, Issue 1, Page 198-206, January 2026.
ABSTRACT Coumarins are considered a privileged scaffold in medicinal chemistry, as they may interact with biological macromolecules, presenting several pharmacological properties. Their potential makes them an object of study for the evaluation of their safety for humans, which is essential in the design of a potential drug.
Júlia Zocca Nunes de Barros, Luma Eduarda Lopes Escalante, Maria João Matos, Edson Luis Maistro   +3 more
wiley   +1 more source

Novel Gallate Triphenylphosphonium Derivatives with Potent Antichagasic Activity. [PDF]

PLoS ONE, 2015
disease is one of the most neglected tropical diseases in the world, affecting nearly 15 million people, primarily in Latin America. Only two drugs are used for the treatment of this disease, nifurtimox and benznidazole. These drugs have limited efficacy
Leonel A Cortes, Lorena Castro, Bárbara Pesce, Juan D Maya, Jorge Ferreira, Vicente Castro-Castillo, Eduardo Parra, José A Jara, Rodrigo López-Muñoz   +8 more
doaj   +1 more source

Seasonal Dynamics and Associated Risk Factors of Bovine Trypanosomosis and Its Vector in Selected Districts of Gamo and Gofa Zones, Southern Ethiopia

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
The median PCV of poor body‐conditioned animals is below 20 (anaemic) compared to corresponding body‐condition animals. Black‐ and red‐coloured animals are more significantly affected by trypanosomosis than white‐coloured animals. Multivariable logistic regression revealed more about contributory factors than univariable logistic regression.
Solomon Mekuria, Aschenaki Kalsa
wiley   +1 more source

Structure-Based and Molecular Modeling Studies for the Discovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti-Trypanosoma cruzi Activity

Frontiers in Chemistry, 2019
Chagas disease causes ~10,000 deaths each year, mainly in Latin America, where it is endemic. The currently available chemotherapeutic agents are ineffective in the chronic stage of the disease, and the lack of pharmaceutical innovation for Chagas ...
Rafael A. A. Ferreira, Ivani Pauli, Thiago S. Sampaio, Mariana L. de Souza, Leonardo L. G. Ferreira, Luma G. Magalhães, Celso de O. Rezende, Rafaela S. Ferreira, Renata Krogh, Luiz C. Dias, Adriano D. Andricopulo   +10 more
doaj   +1 more source

Benzoic Acid Derivatives with Trypanocidal Activity: Enzymatic Analysis and Molecular Docking Studies toward Trans-Sialidase

Molecules, 2017
Chagas, or American trypanosomiasis, remains an important public health problem in developing countries. In the last decade, trans-sialidase has become a pharmacological target for new anti-Chagas drugs.
Muhammad Kashif, Antonio Moreno-Herrera, Juan Carlos Villalobos-Rocha, Benjamín Nogueda-Torres, Jaime Pérez-Villanueva, Karen Rodríguez-Villar, José Lius Medina-Franco, Peterson de Andrade, Ivone Carvalho, Gildardo Rivera   +9 more
doaj   +1 more source

Exploring Bioactive Metabolites From Fusarium falciforme and Aspergillus terreus Isolated From Protease‐Rich Fruits: Antifungal, Antitrypanosomal, and Enzymatic Inhibitory Activities

Chemistry &Biodiversity, Volume 22, Issue 11, November 2025.
Metabolites from fungi isolated from protease rich‐fruits displayed antifungal, antitrypanosomal and enzymatic inhibitory activities. ABSTRACT Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from
Gabriela de Oliveira Almeida, Vitor de Souza Mazucato, Ludmilla Tonani, Marcia Regina von Zeska Kress, Gisele Barbosa, Renata Krogh, Adriano Defini Andricopulo, Leonardo Luiz Gomes Ferreira, Paulo Cezar Vieira   +8 more
wiley   +1 more source

Vascular Growth Factor Inhibition with Bevacizumab Improves Cardiac Electrical Alterations and Fibrosis in Experimental Acute Chagas Disease

Biology, 2023
Chagas disease (CD) caused by Trypanosoma cruzi is a neglected illness and a major reason for cardiomyopathy in endemic areas. The existing therapy generally involves trypanocidal agents and therapies that control cardiac alterations.
Lindice Mitie Nisimura, Roberto Rodrigues Ferreira, Laura Lacerda Coelho, Gabriel Melo de Oliveira, Beatriz Matheus Gonzaga, Marcelo Meuser-Batista, Joseli Lannes-Vieira, Tania Araujo-Jorge, Luciana Ribeiro Garzoni   +8 more
doaj   +1 more source

Essential Oil Profiles of Lippia turbinata (Verbenaceae) from Argentina: Insights from a Systematic Review and Meta‐Analysis

ChemistryOpen, Volume 14, Issue 11, November 2025.
This study systematically reviews essential oil (EO) profiles of Lippia turbinata (Verbenaceae) populations from Argentina. A meta‐analysis reveals significant chemical variability and distinct chemotypes, primarily defined by limonene, carvone, β‐caryophyllene, and caryophyllene oxide.
Fernando Livio Corzo, Franco Emmanuel Calvo, Emilio Fernando Lizarraga, Guillermo Emilio Marcial, Maria Ines Mercado   +4 more
wiley   +1 more source

Phenotypic Evaluation of Nucleoside Analogues against Trypanosoma cruzi Infection: In Vitro and In Vivo Approaches

Molecules, 2022
Chagas disease, caused by Trypanosoma cruzi (T. cruzi), is a serious public health problem. Current treatment is restricted to two drugs, benznidazole and nifurtimox, displaying serious efficacy and safety drawbacks.
Ludmila F. de A. Fiuza, Denise G. J. Batista, Roberson D. Girão, Fabian Hulpia, Paula Finamore-Araújo, Mustafa M. Aldfer, Ehab Kotb Elmahallawy, Harry P. De Koning, Otacílio Moreira, Serge Van Calenbergh, Maria de Nazaré C. Soeiro   +10 more
doaj   +1 more source

Ruthenium-catalyzed C–H oxygenation of quinones by weak O-coordination for potent trypanocidal agents

Chemical Communications, 2018
C–H oxygenation of quinones by weak O-coordination was achieved by versatile ruthenium(ii) catalysis with ample substrate scope and trypanocidal compounds were also identified.
Gleiston G. Dias, Torben Rogge, Rositha Kuniyil, Claus Jacob, Rubem F. S. Menna‐Barreto, Eufrânio N. da Silva Júnior, Lutz Ackermann   +6 more
openalex   +5 more sources