Results 81 to 90 of about 3,404 (180)

Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
A series of isatinylhydantoin derivatives were synthesized and investigated for antileishmanial and antitrypanosomal activities in vitro and in vivo. The derivative 5 was identified with higher leishmanicidal activity than the clinical drug amphotericin B while 4b was uncovered as in vitro trypanocidal hit against T. congolense parasite.
Keamogetswe Sechoaro, Janine Aucamp, Christina Kannigadu, Helena D. Janse van Rensburg, Keisuke Suganuma, David D. N'Da   +5 more
wiley   +1 more source

Exploration of Novel “Ferroxazide/Ferrazone” Derivatives as Antitrypanosomatid Agents: Design, Synthesis, and Biological Efficacy

Applied Organometallic Chemistry, Volume 39, Issue 1, January 2025.
A series of novel ferrocene derivatives, mimics of the clinical antibiotics, nifuroxazide and nitrofurazone, termed ferroxazides and ferrazones, respectively, were synthesized and evaluated for antitrypanosomatid activities. The ferroxazide 15 bearing dimethylamino moiety was identified in vitro as hit against Trypanosoma congolense strain but ...
Christina Kannigadu, Helena D. Janse van Rensburg, Janine Aucamp, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source

Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody

eLife
African trypanosomes are the causative agents of neglected tropical diseases affecting both humans and livestock. Disease control is highly challenging due to an increasing number of drug treatment failures.
Joar Esteban Pinto Torres, Mathieu Claes, Rik Hendrickx, Meng Yuan, Natalia Smiejkowska, Pieter Van Wielendaele, Aysima Hacisuleyman, Hans De Winter, Serge Muyldermans, Paul AM Michels, Malcolm D Walkinshaw, Wim Versées, Guy Caljon, Stefan Magez, Yann G-J Sterckx   +14 more
doaj   +1 more source

The carbonic anhydrase enzymes as new targets for the management of neglected tropical diseases

Archiv der Pharmazie, Volume 358, Issue 1, January 2025.
The scientific literature dealing with the identification and development of selective inhibitors of the carbonic anhydrases expressed by the protozoans Trypanosoma cruzi (T. cruzi) and Leishmania spp. is reviewed and analyzed, with the aim to sustain the validation process of new classes of drugs useful for the management of neglected tropical ...
Gioele Renzi, Federico Ladu, Fabrizio Carta, Claudiu T. Supuran   +3 more
wiley   +1 more source

Nutritional, Nutraceutical, and Medicinal Potential of Cantharellus cibarius Fr.: A Comprehensive Review

Food Science &Nutrition, Volume 13, Issue 1, January 2025.
This review explores the nutritional, nutraceutical, and medicinal potential of Cantharellus cibarius, known as the “Golden chanterelle.” Emphasizing its rich composition of bioactive compounds and wide range of health benefits, the review also covers ecological significance, preservation strategies, and potential applications in dietary supplements ...
Ajay Kumar, Reema Devi, Rajni Dhalaria, Ashwani Tapwal, Rachna Verma, Summya Rashid, Gehan M. Elossaily, Khalid Ali Khan, Kow‐Tong Chen, Tarun Verma   +9 more
wiley   +1 more source

Tris(3-methoxypropyl)tin aminobenzoates as potentially trypanocidal agent

, 2004
A set of tris(3-methoxypropyl)tin aminobenzoates and N-(4,6-diamino-1,3,5-triazin-2-yl-)aminobenzoates as compounds with potential trypanocidal activity have been prepared and their solubility in water was determined. On the basis of their 13C and 119Sn NMR spectra and IR spectra, bonding relations in these esters are discussed and a model of the ...
Lenka Semenyšínová, Karel Handlíř
openalex   +2 more sources

Insights into Chagas treatment based on the potential of bacteriocin AS-48

International Journal for Parasitology: Drugs and Drug Resistance, 2019
Chagas disease caused by the protozoan parasite Trypanosoma cruzi represents a significant public health problem in Latin America, affecting around 8 million cases worldwide.
Rubén Martín-Escolano, Rubén Cebrián, Javier Martín-Escolano, Maria J. Rosales, Mercedes Maqueda, Manuel Sánchez-Moreno, Clotilde Marín   +6 more
doaj   +1 more source

Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease

Frontiers in Pharmacology, 2019
Leishmaniasis and Chagas disease cause great impact on social and economic aspects of people living in developing countries. The treatments for these diseases are based on the same regimen for over 40 years, thus, there is an urgent need for the ...
Roberval Nascimento Moraes Neto, Ruth Flávia Barros Setúbal, Taciana Mirely Maciel Higino, Maria Carolina Accioly Brelaz-de-Castro, Luís Cláudio Nascimento da Silva, Amanda Silva dos Santos Aliança   +5 more
doaj   +1 more source

Ligand-Based Virtual Screening and Molecular Docking of Benzimidazoles as Potential Inhibitors of Triosephosphate Isomerase Identified New Trypanocidal Agents. [PDF]

Int J Mol Sci, 2022
Vázquez-Jiménez LK, Juárez-Saldivar A, Gómez-Escobedo R, Delgado-Maldonado T, Méndez-Álvarez D, Palos I, Bandyopadhyay D, Gaona-Lopez C, Ortiz-Pérez E, Nogueda-Torres B, Ramírez-Moreno E, Rivera G.   +11 more
europepmc   +1 more source

Computer-Aided Design and Synthesis of a New Class of PEX14 Inhibitors: Substituted 2,3,4,5-Tetrahydrobenzo[F][1,4]oxazepines as Potential New Trypanocidal Agents [PDF]

, 2021
Roberto Fino, Dominik Lenhart, Vishal C. Kalel, Charlotte A. Softley, Valeria Napolitano, Ryan Byrne, Wolfgang Schliebs, Maciej Dawidowski, Ralf Erdmann, Michael Sattler, Gisbert Schneider, Oliver Plettenburg, Grzegorz M. Popowicz   +12 more
openalex   +1 more source