Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance [PDF]
Tropical Medicine and Infectious Disease, 2022 Background: African trypanocide resistance is an emerging public health emergency whose control requires a revisit on farmer’s knowledge, attitudes, and practices in developing countries.
Keneth Iceland Kasozi +5 more
doaj +2 more sources
Systematic Review and Meta-Analysis on Human African Trypanocide Resistance [PDF]
Pathogens, 2022 Background Human African trypanocide resistance (HATr) is a challenge for the eradication of Human African Trypansomiaisis (HAT) following the widespread emergence of increased monotherapy drug treatment failures against Trypanosoma brucei gambiense and ...
Keneth Iceland Kasozi +2 more
doaj +2 more sources
Nanoformulation of a Trypanocidal Drug Isometamidium Chloride Ameliorates the Apurinic-Apyrimidinic DNA Sites/Genotoxic Effects in Horse Blood Cells [PDF]
Journal of Xenobiotics, 2023 Isometamidium chloride (ISM) is a trypanocide for the prophylactic and therapeutic use against vector-borne animal trypanosomosis (mainly Surra caused by Trypanosoma evansi) and African animal trypanosomosis caused by T. congolense/T. vivax/T.
Sandeep Singh +5 more
doaj +2 more sources
Trypanocide usage in the cattle belt of southwestern Uganda [PDF]
Frontiers in Microbiology, 2023 BackgroundSystematic infrastructure and regulatory weaknesses over many decades, in communities struggling with animal African trypanosomiasis (AAT) would be expected to create an environment that would promote drug misuse and risk development of drug ...
Keneth Iceland Kasozi +6 more
doaj +2 more sources
Longitudinal observational (single cohort) study on the causes of trypanocide failure in cases of African animal trypanosomosis in cattle near wildlife protected areas of Northern Tanzania. [PDF]
PLoS Neglected Tropical DiseasesAfrican animal trypanosomosis (AAT) in cattle is primarily managed through trypanocide administration and insecticide application. Trypanocides can be used for both treatment and prophylaxis, but failure is often reported; this may occur due to ...
Shauna Richards +13 more
doaj +2 more sources
Vector competence of sterile male Glossina fuscipes fuscipes for Trypanosoma brucei brucei: implications for the implementation of the sterile insect technique in a sleeping sickness focus in Chad [PDF]
Parasites & Vectors, 2023 Background Human African trypanosomiasis (HAT) is a neglected tropical disease caused by Trypanosoma brucei gambiense transmitted by tsetse flies in sub-Saharan West Africa. In southern Chad the most active and persistent focus is the Mandoul focus, with
Mahamat Hissene Mahamat +8 more
doaj +2 more sources
African animal trypanocide resistance: A systematic review and meta-analysis [PDF]
Frontiers in Veterinary Science, 2023 BackgroundAfrican animal trypanocide resistance (AATr) continues to undermine global efforts to eliminate the transmission of African trypanosomiasis in endemic communities. The continued lack of new trypanocides has precipitated drug misuse and overuse,
Keneth Iceland Kasozi +4 more
doaj +2 more sources
An Update on African Trypanocide Pharmaceutics and Resistance [PDF]
Frontiers in Veterinary Science, 2022 African trypanosomiasis is associated with Trypanosoma evansi, T. vivax, T. congolense, and T. brucei pathogens in African animal trypanosomiasis (AAT) while T. b gambiense and T.
Keneth Iceland Kasozi +5 more
doaj +2 more sources
Trypanocide Use and Molecular Characterization of Trypanosomes Resistant to Diminazene Aceturate in Cattle in Northern Côte D’Ivoire [PDF]
Tropical Medicine and Infectious DiseaseThe resistance of trypanosomes to the doses of trypanocide administered by farmers to their animals acts as a real brake on efforts to control to combat African trypanosomiasis.
Jean-Yves Ekra +6 more
doaj +2 more sources
Clinical trials for Chagas disease: etiological and pathophysiological treatment [PDF]
Frontiers in Microbiology, 2023 Chagas disease (CD) is caused by the flagellate protozoan Trypanosoma cruzi. It is endemic in Latin America. Nowadays around 6 million people are affected worldwide, and 75 million are still at risk. CD has two evolutive phases, acute and chronic.
Beatriz Matheus de Souza Gonzaga +5 more
doaj +2 more sources