Results 11 to 20 of about 611 (151)

One Health policy for combatting African trypanocide resistance [PDF]

One Health
The rise of African trypanocide resistance (ATr) is influenced by various factors such as evolutionary changes in the pathogen, the presence of resistance genes in the population, poor policy decisions, limited private-public partnerships to engage local
Keneth Iceland Kasozi, Ewan Thomas MacLeod, Susan Christina Welburn   +2 more
doaj   +2 more sources

Prevalence of trypanosomes associated with drug resistance in Shimba Hills, Kwale County, Kenya [PDF]

BMC Research Notes, 2020
Objective Animal African trypanosomiasis (AAT) is a life-threatening vector-borne disease, caused by trypanosome parasites, which are principally transmitted by tsetse flies.
Benard W. Kulohoma, Sarah A. O. Wamwenje, Ibrahim I. Wangwe, Nicodemus Masila, Caroline K. Mirieri, Lillian Wambua   +5 more
doaj   +2 more sources

Ascofuranone antibiotic is a promising trypanocidal drug for nagana [PDF]

Onderstepoort Journal of Veterinary Research
Trypanosomosis is a disease complex which affects both humans and animals in sub-Saharan Africa, transmitted by the tsetse fly and distributed within the tsetse belt of Africa.
Keisuke Suganuma, Kennedy M. Mochabo, Judith K. Chemuliti, Kita Kiyoshi, Inoue Noboru, Shin-ichiro Kawazu   +5 more
doaj   +2 more sources

Equine trypanosomiasis, a systematic review and meta-analyses: Prevalence, morbidity and mortality. [PDF]

Equine Vet J
Abstract Background Equine trypanosomiasis is a neglected protozoal disease. Objectives To perform a systematic search of literature to explore: (1) In equines what is the global geographical distribution and prevalence of trypanosomiasis? In low and middle‐income countries (LMICs) is trypanosomiasis more prevalent than in higher‐income countries (HICs)
Raftery AG, Gummery L, Garcia K, Mohite D, Capewell P, Sutton DGM.   +5 more
europepmc   +2 more sources

Piplartine Synthetic Analogs: In Silico Analysis and Antiparasitic Study against Trypanosoma cruzi

Applied Sciences, 2023
Neglected tropical diseases (NTDs) cause thousands of deaths each year. Among these diseases, we find Chagas disease, whose etiologic agent is Trypanosoma cruzi.
Rayanne H. N. Silva, Emanuel P. Magalhães, Rebeca C. Gomes, Yunierkis Perez-Castillo, Alice M. C. Martins, Damião P. de Sousa   +5 more
doaj   +1 more source

Chemosensitization of Trypanosoma congolense strains resistant to isometamidium chloride by tetracyclines and enrofloxacin. [PDF]

PLoS Neglected Tropical Diseases, 2010
BACKGROUND: Because of the development of resistance in trypanosomes to trypanocidal drugs, the livelihood of millions of livestock keepers in sub-Saharan Africa is threatened now more than ever.
Vincent Delespaux, Hervé Sèna Vitouley, Tanguy Marcotty, Niko Speybroeck, Dirk Berkvens, Krisna Roy, Stanny Geerts, Peter Van den Bossche   +7 more
doaj   +1 more source

Antitrypanosomal Activity and Molecular Docking Studies of Lobetyolin From <i>Lobelia rhynchopetalum</i> Hemsl. Root Extract Against <i>Trypanosoma congolense</i> Field Isolates. [PDF]

Biomed Res Int
Currently available drugs for trypanosomiasis are few, and their use is limited by toxicity and growing resistance. This highlights the need for safer and more effective alternatives. In this study, the in vitro and in vivo antitrypanosomal activities of an 80% methanol root extract of Lobelia rhynchopetalum and its major constituent were evaluated ...
Yimer S, Tewelde E, Bisrat D, Tadesse S, Yeshak MY.   +4 more
europepmc   +2 more sources

‘Antrycide' : A New Trypanocidal Drug [PDF]

Nature, 1949
THE discovery of a new drug, ‘Antrycide'*, showing great promise in comprehensive field trials as a trypanocide, has already been referred to in an announcement from the Colonial Office. This new drug resulted from a systematic study of the chemotherapy of trypanosomiasis in these Laboratories, and although a full account of our researches must await ...
F H S, CURD, D G, DAVEY
openaire   +3 more sources

Spatial–Temporal Variations in Parasitological Prevalence and Host‐Related Risk Factors of Camel Trypanosomiasis and Its Vectors in North Eastern Kenya: A Repeated Cross‐Sectional Study

Journal of Parasitology Research, Volume 2023, Issue 1, 2023., 2023
Camel trypanosomiasis (Surra) is endemic in the Horn of Africa. Understanding the spatiotemporal variations in Surra prevalence, vector dynamics, and host‐related risk factors is important in developing effective control strategies. A repeated cross‐sectional study was conducted to determine the Surra parasitological prevalence, livestock reservoirs ...
Kennedy O. Ogolla, Judith K. Chemuliti, Florence N. Wamwiri, Joanna E. Auma, Richard K. Kurgat, Kennedy B. Wanjala, Lawrence G. Mugunieri, Phylis M. Alusi, Raymond E. Mdachi, Phoebe W. Mukiria, Sylvance O. Okoth, Bernard Marchand   +11 more
wiley   +1 more source

Core‐Shell DNA‐Cholesterol Nanoparticles Exert Lysosomolytic Activity in African Trypanosomes**

ChemBioChem, Volume 23, Issue 20, October 19, 2022., 2022
The bioengineering of synthetic nanoparticles with therapeutic potential for the treatment of African sleeping sickness is reported. The molecules are DNA‐cholesterol amphiphiles, which self‐assemble into micelle‐type nanoparticles with an exterior DNA shell and a lipid core. The particles are constructed to attack two parasite‐specific targets thereby
Robert Knieß, Wolf‐Matthias Leeder, Paul Reißig, Felix Klaus Geyer, H. Ulrich Göringer   +4 more
wiley   +1 more source