Results 21 to 30 of about 1,868 (198)

Core‐Shell DNA‐Cholesterol Nanoparticles Exert Lysosomolytic Activity in African Trypanosomes**

ChemBioChem, Volume 23, Issue 20, October 19, 2022., 2022
The bioengineering of synthetic nanoparticles with therapeutic potential for the treatment of African sleeping sickness is reported. The molecules are DNA‐cholesterol amphiphiles, which self‐assemble into micelle‐type nanoparticles with an exterior DNA shell and a lipid core. The particles are constructed to attack two parasite‐specific targets thereby
Robert Knieß, Wolf‐Matthias Leeder, Paul Reißig, Felix Klaus Geyer, H. Ulrich Göringer   +4 more
wiley   +1 more source

Investigation on Prevalence of Canine Trypanosomiasis in the Conservation Areas of Bwindi‐Mgahinga and Queen Elizabeth in Western Uganda

Journal of Parasitology Research, Volume 2022, Issue 1, 2022., 2022
Nowadays, despite the instauration of several control strategies, animal trypanosomiasis continues to be reported all over Uganda. Few canine African trypanosomiasis (CAT) studies have been carried out, yet dogs are known Trypanosoma reservoirs that share identical home ranges with livestock and serve as parasite link between livestock and humans. This
James Robert Ochieng, Marta Planellas Bachs, Anthony Nsubuga, Innocent B. Rwego, John Joseph M. Kisakye, Laura Muro Riba, Jesus Muro Figueres, John Kagira   +7 more
wiley   +1 more source

Design, Synthesis and Biological Activity of C3 Hemisynthetic Triterpenic Esters as Novel Antitrypanosomal Hits

ChemistryOpen, Volume 10, Issue 9, Page 896-903, September 2021., 2021
A library of 12 C3 triterpenic esters was readily synthesized and tested for antiparasitic activity and cytotoxicity evaluation. C3 esterification kept the activity while lowering the cytotoxicity. The most potent antitrypanosomal activity, coupled with great selectivity, was shown by 2‐fluoro phenylpropionate, phenylpropionate and α‐methyl ...
Laura Schioppa, Claire Beaufay, Natacha Bonneau, Marianela Sanchez, Cynthia Girardi, Aurélie Leverrier, Sergio Ortiz, Jorge Palermo, Jacques H. Poupaert, Joëlle Quetin‐Leclercq   +9 more
wiley   +1 more source

Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential

Molecular Microbiology, Volume 116, Issue 2, Page 564-588, August 2021., 2021
Resistance to diminazene is one of the main problems facing the control of the livestock disease Animal African Trypanosomiasis (AAT, or nagana), caused by the parasite Trypanosoma congolense. We investigated the adaptations of the parasite that allow it to resist the drug and find that changes to the mitochondrion, where the parasite produces its ...
Lauren V. Carruthers, Jane C. Munday, Godwin U. Ebiloma, Pieter Steketee, Siddharth Jayaraman, Gustavo D. Campagnaro, Marzuq A. Ungogo, Leandro Lemgruber, Anne‐Marie Donachie, Tim G. Rowan, Rose Peter, Liam J. Morrison, Michael P. Barrett, Harry P. De Koning   +13 more
wiley   +1 more source

Integrated cost-benefit analysis of tsetse control and herd productivity to inform control programs for animal African trypanosomiasis [PDF]

, 2018
Animal African trypanosomiasis (AAT) and its tsetse vector are responsible for annual losses estimated in billions of US dollars ($). Recent years have seen the implementation of a series of multinational interventions.
Chilongo, K, Fauron, A, Gilbert, W, Guitian, J, Holt, H R, Meyer, A, Mumba, C, Oumarou,, F   +7 more
core   +1 more source

First case report on the occurrence of Trypanosoma evansi in a Siam B Mare in Kelantan, Malaysia

Veterinary Medicine and Science, Volume 7, Issue 2, Page 303-309, March 2021., 2021
This first positive Surra case in Siam B mare in Kelantan, Malaysia, that is bordering Thailand confirms the increasing concern of transboundary infections. Thin blood smear and examination revealed the presence of Trypanosoma sp., and it was confirmed as T. evansi through molecular identification.
Nur Zul Izzati Mohd Rajdi, Mimi Armiladiana Mohamad, Li Peng Tan, Siew Shean Choong, Mohd Farhan Hanif Reduan, Ruhil Hayati Hamdan, C. W. Salma C. W. Zalati   +6 more
wiley   +1 more source

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer, Agbe, Bruhn, Brun, Cristodero, Dean, Deterding, Herbert, Hoare, Holmes, Kaminsky, Lai, Lanteri, M. K. Gould, Mathis, Mukherjee, Painter, Priest, Roy Chowdhury, Räz, Schnaufer, Schnaufer, Schnaufer, Shapiro, Stuart, Tang, Thuita, Ward, Wenzler, Wenzler, Wilson, Zhang, Zuma   +32 more
core   +1 more source

Stress Induces Release of Extracellular Vesicles by Trypanosoma cruzi Trypomastigotes

Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021
All extracellular forms of Trypanosoma cruzi, the causative agent of Chagas disease, release extracellular vesicles (EVs) containing major surface molecules of the parasite. EV release depends on several mechanisms (internal and external). However, most of the environmental conditions affecting this phenomenon are still unknown.
Camilla Ioshida Vasconcelos, A Cronemberger-Andrade, Normanda Souza-Melo, Juliana Terzi Maricato, Patrícia Xander, Wagner Luiz Batista, Rodrigo Pedro Soares, Sergio Schenkman, Ana Claudia Torrecilhas, Ilaria Roato   +9 more
wiley   +1 more source

Prevalence of Bovine Trypanosomosis and Its Associated Risk Factor in Hawa Galan District, Kelem Wollega Zone of Ethiopia

Veterinary Medicine International, Volume 2021, Issue 1, 2021., 2021
An analytical cross‐sectional study was performed between November 2015 and April 2016 at Hawa Galan woreda, Kelem Wollega Zone, Oromia Region, Ethiopia, to estimate the proportion of cattle with trypanosomosis and to evaluate the elements associated with the prevalence of bovine trypanosomosis.
Girma Tsegaye, Belay Abebe, Geremew Haile, Remo Lobetti   +3 more
wiley   +1 more source

Résistance médicamenteuse d'isolats récents de Trypanosoma brucei et Trypanosoma congolense

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1988
Des études ont été menées sur des souris pour déterminer la sensibilité aux médicaments d’isolats récents de Trypanosoma brucei et Trypanosoma congolense. Chacune des onze souches de T. congolense et des cinq souches de T. brucei, toutes isolées sur des
R.A. Joshua
doaj   +1 more source