Results 41 to 50 of about 611 (151)

Traitement de la maladie du sommeil du bétail au dimidium bromide

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1948
Aucun résumé disponible.
M. Blommaert
doaj   +1 more source

Synthesis and Evaluation of Trypanocidal Activity of Chromane-Type Compounds and Acetophenones

Molecules, 2021
American trypanosomiasis (Chagas disease) caused by the Trypanosoma cruzi parasite, is a severe health problem in different regions of Latin America and is currently reported to be spreading to Europe, North America, Japan, and Australia, due to the ...
Luis A. González, Sara Robledo, Yulieth Upegui, Gustavo Escobar, Wiston Quiñones   +4 more
doaj   +1 more source

Trypanocidal Activity of Aziridinyl Nitrobenzamide Prodrugs [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACT The trypanocidal agents nifurtimox and benznidazole both function as prodrugs and must undergo enzyme-mediated activation, a reaction catalyzed by type I nitroreductase (NTR). In the search for new parasitic therapies, we have utilized this finding to investigate whether aziridinyl nitrobenzamide derivatives have ...
Bot, C, Hall, BS, Bashir, N, Taylor, MC, Helsby, NA, Wilkinson, SR   +5 more
openaire   +3 more sources

Natural Products from Mexican Medicinal Plants as Promising Trypanocidal Drugs

ChemistrySelect, Volume 10, Issue 37, October 6, 2025.
Chagas disease (American Trypanosomiasis) is caused by the protozoan Trypanosoma cruzi. Worldwide it is one of the seventeen neglected tropical diseases. There is a need of new drugs. This review assesses the literature (2012‐2024) of secondary metabolites isolated from Mexican plants active against this parasite.
Karla Daniela Rodríguez‐Hernández, Elia Guadalupe Jaimes‐Castelán, Ricardo Reyes‐Chilpa   +2 more
wiley   +1 more source

Synthesis of (-) - 6,6'-dinitrohinokinin from hinokinin natural product and in silico and in vitro trypanocidal activity assessment

Bioscience Journal
Chagas disease is a public health problem affecting approximately seven million people worldwide. Thus, there is a need to discover drugs for the adequate treatment of this disease because currently available drugs have serious side effects.
Suziene Caroline Silva Cardoso, Wilson R. Cunha, Pedro S. dos S. R. Cavallari, Samarah Gomes de Almeida, Ana Helena Januário, Patrícia Mendonça Pauletti, Fernanda Amorim Santos, Rosângela da Silva Laurentiz, Giulia Stavrakas Miranda, João Victor Andrade, Renato Pereira Orenha, Renato Luis Tame Parreira, Márcio Luís Andrade e Silva, Mario F. C. Santos, Viviane Esperandim   +14 more
doaj   +1 more source

Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs

Molecules, 2019
Treatment of animal African trypanosomiasis (AAT) requires urgent need for safe, potent and affordable drugs and this has necessitated this study.
Charles O. Nnadi, Godwin U. Ebiloma, Jennifer A. Black, Ngozi J. Nwodo, Leandro Lemgruber, Thomas J. Schmidt, Harry P. de Koning   +6 more
doaj   +1 more source

Impact of long‐term mass‐rearing on the genetic structure of tsetse fly Glossina palpalis gambiensis colonies

Insect Science, Volume 32, Issue 5, Page 1575-1587, October 2025.
Abstract Tsetse flies are the sole cyclic vectors of African trypanosomes, which cause human and animal African trypanosomiases in Africa. Tsetse fly control remains a promising option for disease management. The sterile insect technique (SIT) stands as an environmentally friendly tool to control tsetse populations.
Kiswend‐sida M. Dera, Soumaïla Pagabeleguem, Tito Tresor Melachio Tanekou, Ange Irénée Toé, Gisèle Marie Sophie Ouedraogo‐Sanou, Adrien Marie Gaston Belem, Sophie Ravel, Robert L. Mach, Marc J. B. Vreysen, Adly M.M. Abd‐Alla   +9 more
wiley   +1 more source

Insights into Ergosterol Peroxide’s Trypanocidal Activity [PDF]

Biomolecules, 2019
Trypanosoma cruzi, which causes Chagas disease, is a significant health threat in many countries and affects millions of people. Given the magnitude of this disease, a broader understanding of trypanocidal mechanisms is needed to prevent and treat infection.
Thuluz Meza-Menchaca, Angel Ramos-Ligonio, Aracely López-Monteon, Abraham Vidal Limón, Leonid Kaluzhskiy, Tatjana V. Shkel, Natallia V. Strushkevich, Luis Jiménez-García, Lourdes Agredano Moreno, Verónica Gallegos-García, Jorge Suárez-Medellín, Ángel Trigos   +11 more
openaire   +3 more sources

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, Volume 32, Issue 5, Page 1747-1760, October 2025.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source

Design, synthesis and identification of novel molecular hybrids based on naphthoquinone aromatic hydrazides as potential trypanocide and leishmanicidal agents

Anais da Academia Brasileira de Ciências
In pursuit of potential agents to treat Chagas disease and leishmaniasis, we report the design, synthesis, and identification novel naphthoquinone hydrazide-based molecular hybrids.
ROSANE D. CEZAR, ADRIANO O. DA SILVA, ROSÂNGELA S. LOPES, CELSO V. NAKAMURA, JEAN HENRIQUE S. RODRIGUES, ESTELA MARIANA G. LOURENÇO, SUMBAL SABA, ADILSON BEATRIZ, JAMAL RAFIQUE, DÊNIS P. DE LIMA   +9 more
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