Results 61 to 70 of about 944 (184)
DFMO inhibition of neuroblastoma tumorigenesis
Cancer Medicine, Volume 13, Issue 9, May 2024.Abstract Background Most high‐risk neuroblastoma patients who relapse succumb to disease despite the existing therapy. We recently reported increased event‐free and overall survival in neuroblastoma patients receiving difluoromethylornithine (DFMO) during maintenance therapy.
Divya Gandra +8 more
wiley +1 more source
Infection expérimentale de zébus guyanais avec Trypanosoma vivax
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1990 La souche guyanaise de Trypanosoma vivax est pathogène pour le zébu guyanais de type Brahman : l'infection expérimentale de 19 bovins, agés d'un an, s'est traduite par de la fièvre (peu élevée et transitoire), une chute de l'hématocrite et une perte de ...
Emmanuel Camus, Arnaud Martrenchar
doaj +1 more source
Fundamental &Clinical Pharmacology, Volume 38, Issue 1, Page 72-83, February 2024.Abstract Human African trypanosomosis (HAT) which is also known as sleeping sickness is caused by Trypanosoma brucei gambiense that is endemic in western and central Africa and T. b. rhodesiense that is endemic in eastern and southern Africa. Drugs used for treatment against HAT first stage have limited effectiveness, and the second stage drugs have ...
Anna Seetsi +5 more
wiley +1 more source
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1991 Les auteurs ont étudié l'activité théapeutique et prophylactique de l'association DL-alpha-difluorométhylornithine (à la dose de 2 % dans l'eau de boisson) et BerenilR (à 7 mg par kg de poids vif par voie intrapéritonéale) sur des souris infectées par ...
P.A. Onyeyili +3 more
doaj +1 more source
Biogenic trypanocidal sesquiterpenes: lead compounds to design future trypanocidal drugs - a mini review [PDF]
DARU Journal of Pharmaceutical Sciences, 2013 Abstract Human trypanosomiasis is a parasitic disease among poor people in Africa and Latin America. Therapy against African and American trypanosomiasis is based on a few drugs that often cause severe side-effects. Therefore, it is essential to develop drug discovery especially from natural origins. Sesquiterpenes, a diverse group of natural
Saeidnia, Soodabeh +2 more
openaire +2 more sources
International Journal for Parasitology: Drugs and Drug Resistance, 2019 The four components present in the trypanocidal treatment Samorin, the commercially available formulation of isometamidium, were separated and purified by column chromatography.
Anthonius A. Eze +4 more
doaj +1 more source
Evaluating 5-Nitrothiazoles as Trypanocidal Agents [PDF]
Antimicrobial Agents and Chemotherapy, 2016 ABSTRACTThe growth-inhibitory properties of a 5-nitrothiazole series were evaluated againstTrypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expression of a type I nitroreductase by the ...
O'Shea, IP +3 more
openaire +3 more sources
Exploring strategies to address trypanocide resistance: lessons from Uganda
BACKGROUND: Trypanosomiasis is a zoonotic disease with a divergent evolutionary history, and gene speciation which has influenced gene flow. Aim: The objective of the study was to generate evidence on the development of African trypanocide resistance ...
Kasozi, Keneth Iceland
core +1 more source
Action trypanopréventive du M et B 4596
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1963 cf. fichier PDF de l'article.
Pierre Finelle, R. Lacotte
doaj +1 more source
Parasites & Vectors, 2012 Background Tsetse fly-transmitted African animal trypanosomosis causes annual losses that run into billions of dollars. The disease is assumed to cause hunger and poverty in most sub-Saharan countries since it represents a serious impediment to ...
Mungube Erick O +10 more
doaj +1 more source