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In vivo drug experiment involving Trypanosoma evansi (T.evansi) of Bangkalan isolated from outbreakof surra at 1988 in Madura Island, (Indonesia) infected mice were performed.
Muchamad Lazuardi +2 more
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Trypanocidal analogs of myristate and myristoyllysophosphatidylcholine
K A, Werbovetz +2 more
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Trypanocidal action and toxicity to enzymes [PDF]
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THE TRYPANOCIDAL ACTIVITY OF DITHIOBIURET DERIVATIVES [PDF]
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TRYPANOCIDAL ACTION OF PHENANTHRIDINE COMPOUNDS: EFFECT OF CHANGING THE QUATERNARY GROUPS OF KNOWN TRYPANOCIDES [PDF]
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Trypanocidal treatment of Chagas disease
Enfermedades infecciosas y microbiologia clinica (English ed.), 2021Chagas disease is a neglected parasitosis caused by the protozoan parasite Trypanosoma cruzi. This infection is present in most Latin American countries, although, due to migratory movements, it is a growing cause for concern in non-endemic countries. The only two drugs currently available for its treatment-benznidazole and nifurtimox-were marketed 50 ...
Jose A, Pérez-Molina +3 more
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Methylating agents as trypanocides
Journal of Medicinal Chemistry, 1990Methylating agents, such as streptozotocin, procarbazine, N-methyl-N-nitrosourea, dimethyl sulfate, 1,2-dimethylhydrazine, and a series of 1,2-bis(sulfonyl)-1-methylhydrazines synthesized in this laboratory, were evaluated and shown to be therapeutically active against murine models of African trypanosomiasis.
P G, Penketh +4 more
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Biosynthesis of a trypanocide by Chromobacterium violaceum
World Journal of Microbiology and Biotechnology, 1994Radio-isotope studies indicated not only that L-tryptophan can serve as carbon source for synthesis of the trypanocide, violacein by Chromobacterium violaceum (BB-78 strain) but also that isatin and indole 3-acetic acid are both important metabolic intermediates.
Nelson Duran, Duran N, M Haun
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Metamidium: a New Trypanocidal Drug
Nature, 1958THIS communication describes a new trypanocide, which has been found to possess considerable potentiality as a curative and as a prophylactic drug, both in laboratory experiments and in field trials carried out in Africa during the past year.
W R, WRAGG +3 more
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