Results 51 to 60 of about 1,868 (198)

Economic analysis of animal disease control inputs at farm level: the case of trypanocide use in villages under risk of drug resistance in West Africa [PDF]

, 2010
This paper presents an economic analysis of the use of drugs (isometamidium and diminazene) in controlling African Animal Trypanosomosis (AAT), a serious disease of cattle and small ruminants in villages that exhibit resistance to isometamidium in ...
Affognon, Hippolyte D., Randolph, Thomas F., Waibel, H.   +2 more
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African Trypanosomes undermine humoral responses and vaccine development : link with inflammatory responses? [PDF]

, 2017
African trypanosomosis is a debilitating disease of great medical and socioeconomical importance. It is caused by strictly extracellular protozoan parasites capable of infecting all vertebrate classes including human, livestock, and game animals.
Achcar, Alampour-Rajabi, Alirol, Allman, Authie, Authié, Auty, Baker, Balber, Banks, Barry, Barry, Berthier, Beschin, Beschin, Blom-Potar, Bockstal, Bockstal, Boller, Bonnet, Borst, Bosschaerts, Boulange, Bouyer, Brun, Brun, Bucheton, Calandra, Capewell, Chamond, Claes, Cnops, Cnops, Cnops, Cnops, Coller, Dagenais, Darji, De Muylder, De Trez, Delafosse, Delespaux, Desquesnes, Devine, Disease, Drennan, Dubois, Duszenko, Engstler, Fenn, Ferrante, Field, Figarella, Franco, Frenkel, Gilbert, Giordani, Gomez-Rodriguez, Graham, Graham, Haanstra, Hall, Hasker, Hemphill, Holland, Holland, Holt, Jamonneau, Jarvinen, Jones, Keitany, Kennedy, Kennedy, Klasen, Kondo, Kroubi, Kuriakose, La Greca, La Greca, Lalmanach, Lanca, Lebien, Lejon, Lejon, Leng, MacGregor, MacGregor, MacLean, MacLean, Magez, Magez, Magez, Mansfield, McGettrick, Mekori, Millar, Mogk, Mony, Morrison, Morrison, Morrison, Mulindwa, Mårtensson, Naessens, Naula, Ng, Nutt, Obishakin, Odongo, Onyilagha, Ooi, Ooi, Osório, O’Gorman, Paulnock, Pays, Peacock, Priotto, Radwanska, Radwanska, Reth, Rico, Rodgers, Rotureau, Ruiz-Postigo, Salmon, Schwede, Schwede, Seed, Sharpe, Sileghem, Sileghem, Simarro, Simarro, Simarro, Stijlemans, Stijlemans, Stijlemans, Stijlemans, Stijlemans, Stijlemans, Stijlemans, Swallow, Takeya, Taylor, Taylor, Taylor, Telleria, Tiberti, Trindade, Unciti-Broceta, Uzonna, Uzonna, Van Den Abbeele, Vassella, Welburn, Welburn, Wellde, Wenzler, Willert, Yaro   +160 more
core   +1 more source

Trypanocidal Activity of Aziridinyl Nitrobenzamide Prodrugs [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACT The trypanocidal agents nifurtimox and benznidazole both function as prodrugs and must undergo enzyme-mediated activation, a reaction catalyzed by type I nitroreductase (NTR). In the search for new parasitic therapies, we have utilized this finding to investigate whether aziridinyl nitrobenzamide derivatives have ...
Bot, C, Hall, BS, Bashir, N, Taylor, MC, Helsby, NA, Wilkinson, SR   +5 more
openaire   +3 more sources

Impact of long‐term mass‐rearing on the genetic structure of tsetse fly Glossina palpalis gambiensis colonies

Insect Science, Volume 32, Issue 5, Page 1575-1587, October 2025.
Abstract Tsetse flies are the sole cyclic vectors of African trypanosomes, which cause human and animal African trypanosomiases in Africa. Tsetse fly control remains a promising option for disease management. The sterile insect technique (SIT) stands as an environmentally friendly tool to control tsetse populations.
Kiswend‐sida M. Dera, Soumaïla Pagabeleguem, Tito Tresor Melachio Tanekou, Ange Irénée Toé, Gisèle Marie Sophie Ouedraogo‐Sanou, Adrien Marie Gaston Belem, Sophie Ravel, Robert L. Mach, Marc J. B. Vreysen, Adly M.M. Abd‐Alla   +9 more
wiley   +1 more source

Synthesis of (-) - 6,6'-dinitrohinokinin from hinokinin natural product and in silico and in vitro trypanocidal activity assessment

Bioscience Journal
Chagas disease is a public health problem affecting approximately seven million people worldwide. Thus, there is a need to discover drugs for the adequate treatment of this disease because currently available drugs have serious side effects.
Suziene Caroline Silva Cardoso, Wilson R. Cunha, Pedro S. dos S. R. Cavallari, Samarah Gomes de Almeida, Ana Helena Januário, Patrícia Mendonça Pauletti, Fernanda Amorim Santos, Rosângela da Silva Laurentiz, Giulia Stavrakas Miranda, João Victor Andrade, Renato Pereira Orenha, Renato Luis Tame Parreira, Márcio Luís Andrade e Silva, Mario F. C. Santos, Viviane Esperandim   +14 more
doaj   +1 more source

Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs

Molecules, 2019
Treatment of animal African trypanosomiasis (AAT) requires urgent need for safe, potent and affordable drugs and this has necessitated this study.
Charles O. Nnadi, Godwin U. Ebiloma, Jennifer A. Black, Ngozi J. Nwodo, Leandro Lemgruber, Thomas J. Schmidt, Harry P. de Koning   +6 more
doaj   +1 more source

Synthesis and Evaluation of Trypanocidal Activity of Chromane-Type Compounds and Acetophenones

Molecules, 2021
American trypanosomiasis (Chagas disease) caused by the Trypanosoma cruzi parasite, is a severe health problem in different regions of Latin America and is currently reported to be spreading to Europe, North America, Japan, and Australia, due to the ...
Luis A. González, Sara Robledo, Yulieth Upegui, Gustavo Escobar, Wiston Quiñones   +4 more
doaj   +1 more source

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, Volume 32, Issue 5, Page 1747-1760, October 2025.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source

Cinétique de la mort in vitro de Trypanosoma vivax et Trypanosoma congolense Vanderplank au contact de médicaments trypanocides [PDF]

, 1967
Trypanosoma vivax et Trypanosoma congolense ont été soumis in vitro à l'action de trypanocides appartenant à trois familles chimiques: diamidine, quinoléine et phénanthridine.
Touré, Saydil
core  

Insights into Ergosterol Peroxide’s Trypanocidal Activity [PDF]

Biomolecules, 2019
Trypanosoma cruzi, which causes Chagas disease, is a significant health threat in many countries and affects millions of people. Given the magnitude of this disease, a broader understanding of trypanocidal mechanisms is needed to prevent and treat infection.
Thuluz Meza-Menchaca, Angel Ramos-Ligonio, Aracely López-Monteon, Abraham Vidal Limón, Leonid Kaluzhskiy, Tatjana V. Shkel, Natallia V. Strushkevich, Luis Jiménez-García, Lourdes Agredano Moreno, Verónica Gallegos-García, Jorge Suárez-Medellín, Ángel Trigos   +11 more
openaire   +3 more sources