Results 61 to 70 of about 611 (151)

In vitro anti‐trypanosomal activity of synthetic nitrofurantoin‐triazole hybrids against Trypanosoma species causing human African trypanosomosis

Fundamental &Clinical Pharmacology, Volume 38, Issue 1, Page 72-83, February 2024.
Abstract Human African trypanosomosis (HAT) which is also known as sleeping sickness is caused by Trypanosoma brucei gambiense that is endemic in western and central Africa and T. b. rhodesiense that is endemic in eastern and southern Africa. Drugs used for treatment against HAT first stage have limited effectiveness, and the second stage drugs have ...
Anna Seetsi, David D. N'da, Nthatisi Molefe‐Nyembe, Keisuke Suganuma, Tsepo Ramatla, Oriel Thekisoe   +5 more
wiley   +1 more source

Evaluating 5-Nitrofurans as Trypanocidal Agents [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACTThe nitroheterocycle nifurtimox, as part of a nifurtimox-eflornithine combination therapy, represents one of a limited number of treatments targetingTrypanosoma brucei, the causative agent of human African trypanosomiasis. The mode of action of this prodrug involves an initial activation reaction catalyzed by a type I nitroreductase (NTR), an ...
Bot, C, Hall, BS, Alvarez, G, Di Maio, D, Gonzalez, M, Cerecetto, H, WILKINSON, SR   +6 more
openaire   +3 more sources

Activité thérapeutique et prophylactique de la combinaison Berenil^R et DL-alpha-difluorométhylornithine (DFMO^R) contre l’infection à Trypanosoma brucei brucei chez la souris

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1991
Les auteurs ont étudié l'activité théapeutique et prophylactique de l'association DL-alpha-difluorométhylornithine (à la dose de 2 % dans l'eau de boisson) et BerenilR (à 7 mg par kg de poids vif par voie intrapéritonéale) sur des souris infectées par ...
P.A. Onyeyili, G.O. Egwu, L.T. Zaria, B.A. Orjiude   +3 more
doaj   +1 more source

Trypanocidal Activity of Marine Natural Products [PDF]

Marine Drugs, 2013
Marine natural products are a diverse, unique collection of compounds with immense therapeutic potential. This has resulted in these molecules being evaluated for a number of different disease indications including the neglected protozoan diseases, human African trypanosomiasis and Chagas disease, for which very few drugs are currently available.
Amy Jones, Tanja Grkovic, Melissa Sykes, Vicky Avery   +3 more
openaire   +4 more sources

The individual components of commercial isometamidium do not possess stronger trypanocidal activity than the mixture, nor bypass isometamidium resistance

International Journal for Parasitology: Drugs and Drug Resistance, 2019
The four components present in the trypanocidal treatment Samorin, the commercially available formulation of isometamidium, were separated and purified by column chromatography.
Anthonius A. Eze, John Igoli, Alexander I. Gray, Graham G. Skellern, Harry P. De Koning   +4 more
doaj   +1 more source

Trypanocidal Activity of Melamine-Based Nitroheterocycles [PDF]

Antimicrobial Agents and Chemotherapy, 2004
ABSTRACT A series of nitroheterocyclic compounds were designed with linkages to melamine or benzamidine groups that are known substrates of the P2 aminopurine and other transporters in African trypanosomes of the brucei group.
Mhairi L, Stewart, Gorka Jimenez, Bueno, Alessandro, Baliani, Burkhard, Klenke, Reto, Brun, Janice M, Brock, Ian H, Gilbert, Michael P, Barrett   +7 more
openaire   +2 more sources

Action trypanopréventive du M et B 4596

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1963
cf. fichier PDF de l'article.
Pierre Finelle, R. Lacotte
doaj   +1 more source

Detection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali

Parasites & Vectors, 2012
Background Tsetse fly-transmitted African animal trypanosomosis causes annual losses that run into billions of dollars. The disease is assumed to cause hunger and poverty in most sub-Saharan countries since it represents a serious impediment to ...
Mungube Erick O, Vitouley Hervé S, Allegye-Cudjoe Emmanuel, Diall Oumar, Boucoum Zakaria, Diarra Boucader, Sanogo Yousouf, Randolph Thomas, Bauer Burkhard, Zessin Karl-Hans, Clausen Peter-Henning   +10 more
doaj   +1 more source

Trypanosomose et traitements trypanocides chez le veau Ndama en milieu fortement infesté de glossines (ranch de Madina-Diassa au Mali)

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1992
L'épidémiologie de la trypanosomose chez les veaux de race trypanotolérante et l'influence d'un traitement font l'objet de deux études. La première consiste en un suivi parasitologique et clinique de 100 veaux, de la naissance à l'âge d'un an : les ...
O. Diall, O.B. Touré, B. Diarra, Y. Sanogo   +3 more
doaj   +1 more source

Cost analysis of options for management of African Animal Trypanosomiasis using interventions targeted at cattle in Tororo District; south-eastern Uganda

Parasites & Vectors, 2015
Background Tsetse-transmitted African trypanosomes cause both nagana (African animal Trypanosomiasis-AAT) and sleeping sickness (human African Trypanosomiasis - HAT) across Sub-Saharan Africa.
Dennis Muhanguzi, Walter O. Okello, John D. Kabasa, Charles Waiswa, Susan C. Welburn, Alexandra P.M. Shaw   +5 more
doaj   +1 more source