Results 71 to 80 of about 1,868 (198)

Trypanocide counterfeits

The script supports Chapter 5 subsection 2 titled: “Trypanocide advancements and challenges in Uganda” from my PhD thesis titled: Exploring trypanocide resistance: Lessons from Uganda (2024). This describes data (referenced as “trypCounterfeit”) were the quality of trypanocides i.e., diminazene aceturate (DA), isometamidium chloride (ISM) and homidium ...
Kasozi, Keneth Iceland, MacLeod, Ewan Thomas, Welburn, Susan Christina   +2 more
openaire   +2 more sources

Evaluating 5-Nitrothiazoles as Trypanocidal Agents [PDF]

Antimicrobial Agents and Chemotherapy, 2016
ABSTRACTThe growth-inhibitory properties of a 5-nitrothiazole series were evaluated againstTrypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expression of a type I nitroreductase by the ...
O'Shea, IP, Shahed, M, Aguilera-Venegas, B, WILKINSON, SR   +3 more
openaire   +3 more sources

In vitro anti‐trypanosomal activity of synthetic nitrofurantoin‐triazole hybrids against Trypanosoma species causing human African trypanosomosis

Fundamental &Clinical Pharmacology, Volume 38, Issue 1, Page 72-83, February 2024.
Abstract Human African trypanosomosis (HAT) which is also known as sleeping sickness is caused by Trypanosoma brucei gambiense that is endemic in western and central Africa and T. b. rhodesiense that is endemic in eastern and southern Africa. Drugs used for treatment against HAT first stage have limited effectiveness, and the second stage drugs have ...
Anna Seetsi, David D. N'da, Nthatisi Molefe‐Nyembe, Keisuke Suganuma, Tsepo Ramatla, Oriel Thekisoe   +5 more
wiley   +1 more source

Infection expérimentale de zébus guyanais avec Trypanosoma vivax

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1990
La souche guyanaise de Trypanosoma vivax est pathogène pour le zébu guyanais de type Brahman : l'infection expérimentale de 19 bovins, agés d'un an, s'est traduite par de la fièvre (peu élevée et transitoire), une chute de l'hématocrite et une perte de ...
Emmanuel Camus, Arnaud Martrenchar
doaj   +1 more source

Essai de l'efficacité du Cymelarsan (ND) sur Trypanosoma evansi chez le dromadaire [PDF]

, 1989
L'expérimentation au Niger d'une nouvelle molécule arsenicale, susceptible d'être utilisée dans le traitement de la trypanosomose cameline à Trypanosoma evansi a démontré, au cours d'un essai d'efficacité sur 8 jeunes dromadaires infestés ...
Clair, Michel, Itard, Jacques, Tager-Kagan, Pierre   +2 more
core  

Treatment and seroconversion in a cohort of children suffering from recent chronic Chagas infection in Yoro, Honduras [PDF]

, 2009
Between 1999-2002, Médécins Sans Frontières-Spain implemented a project seeking to determine the efficacy and safety of benznidazole in the treatment of recent chronic Chagas disease in a cohort of seropositive children in the Yoro Department, Honduras ...
Bassets, Glòria, Escribà, Josep M, Lima, M Angeles, Marchiol, Andrea, Palma, Pedro Pablo, Ponce, Carlos, Ponce, Elisa, Romero, Alberto de Dios, Viñas, Pedro Albajar, Zúniga, Concepción   +9 more
core   +4 more sources

Evaluating 5-Nitrofurans as Trypanocidal Agents [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACTThe nitroheterocycle nifurtimox, as part of a nifurtimox-eflornithine combination therapy, represents one of a limited number of treatments targetingTrypanosoma brucei, the causative agent of human African trypanosomiasis. The mode of action of this prodrug involves an initial activation reaction catalyzed by a type I nitroreductase (NTR), an ...
Bot, C, Hall, BS, Alvarez, G, Di Maio, D, Gonzalez, M, Cerecetto, H, WILKINSON, SR   +6 more
openaire   +3 more sources

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis [PDF]

, 2011
Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites <i>Trypanosoma brucei</i> (<i>T.b.</i>) <i>gambiense</i> or <i>T.b.rhodesiense</i> and is ...
AA Poltera, Amy Jones, B Evrard, B Raz, Barbara Bradley, BJ Berger, C Burri, C Burri, CA Hunter, Christopher McCabe, E Torreele, EW Hurst, FIC Apted, FW Jennings, George Gettinby, H Hirumi, J Opigo, J Pepin, J Pepin, J Rodgers, J Rodgers, Jayne Raper, Jean Rodgers, JH Zar, JLM Atouguia, JW Wong, Michael P. Barrett, MP Barrett, MP Barrett, NJ Abbott, Peter G. E. Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, RL Carrier, S Ben Zirar, S Gibaud, SL Soignet, Stéphane Gibaud, T Loftsson, T Loftsson, V Lejon, VJ Stella   +45 more
core   +10 more sources

Activité thérapeutique et prophylactique de la combinaison Berenil^R et DL-alpha-difluorométhylornithine (DFMO^R) contre l’infection à Trypanosoma brucei brucei chez la souris

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1991
Les auteurs ont étudié l'activité théapeutique et prophylactique de l'association DL-alpha-difluorométhylornithine (à la dose de 2 % dans l'eau de boisson) et BerenilR (à 7 mg par kg de poids vif par voie intrapéritonéale) sur des souris infectées par ...
P.A. Onyeyili, G.O. Egwu, L.T. Zaria, B.A. Orjiude   +3 more
doaj   +1 more source

Trypanocidal Activity of Marine Natural Products [PDF]

Marine Drugs, 2013
Marine natural products are a diverse, unique collection of compounds with immense therapeutic potential. This has resulted in these molecules being evaluated for a number of different disease indications including the neglected protozoan diseases, human African trypanosomiasis and Chagas disease, for which very few drugs are currently available.
Amy Jones, Tanja Grkovic, Melissa Sykes, Vicky Avery   +3 more
openaire   +4 more sources