Results 91 to 100 of about 54,768 (257)

Structure of thioredoxin from Trypanosoma brucei brucei

FEBS Letters, 2003
The three‐dimensional structure of thioredoxin from Trypanosoma brucei brucei has been determined at 1.4 Å resolution. The overall structure is more similar to that of human thioredoxin than to any other thioredoxin structure. The most striking difference to other thioredoxins is the absence of a buried carboxylate behind the active site cysteines ...
Heide Schmidt, Rosmarie Friemann, R. Luise Krauth-Siegel, Hans Eklund, S. Ramaswamy, Michael Forstner   +5 more
openaire   +3 more sources

Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign.

PLoS Neglected Tropical Diseases, 2012
Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Drugs available for the treatment of HAT have significant issues related to difficult administration regimes ...
Melissa L Sykes, Jonathan B Baell, Marcel Kaiser, Eric Chatelain, Sarah R Moawad, Danny Ganame, Jean-Robert Ioset, Vicky M Avery   +7 more
doaj   +1 more source

Light‐Activated Molecules Targeting G‐Quadruplex Nucleic Acids

Chemistry – A European Journal, Volume 31, Issue 39, July 11, 2025.
We shine a spotlight on the molecular recognition mechanisms and phototherapeutic potential of light‑activated compounds targeting G‑quadruplex nucleic acids, critically evaluating recent breakthroughs and charting the key challenges that must be overcome to drive this promising field forward.
Marta Dudek, Clément Cabanetos, Marco Deiana   +2 more
wiley   +1 more source

Insight into the functional and structural relationship of ornithine decarboxylase and its mutants from Lacticaseibacillus rhamnosus

Bulletin of the Korean Chemical Society, Volume 46, Issue 7, Page 730-742, July 2025.
Structural and functional analysis of Lactaseibacillus rhamnosus ODC highlights a key residue influencing PLP binding, enzymatic activity, and crystal structure, providing insight into its catalytic mechanism. Abstract Ornithine decarboxylase (ODC) is a critical enzyme in the polyamine biosynthesis pathway that catalyzes the conversion of l‐ornithine ...
Nonvide Nicolas Adiko, Hyeon Tae Seo, Dae‐Won Ki, Jung Hee Park, Da Som Kim   +4 more
wiley   +1 more source

Synthesis of biotinylated probes of artemisinin for affinity labeling

Data in Brief, 2015
In this data article, we described the synthetic routes to four biotinylated probes (2, 3, 4, and 5) of artemisinin and the associated experimental procedures. We also provided the physical data for the synthesized compounds.
Benetode Konziase
doaj   +1 more source

The Constructive Neutral Evolution of Behaviour

Ecology and Evolution, Volume 15, Issue 7, July 2025.
We explain how constructive neutral evolution (CNE) can lead to the evolution of nonfunctional behavioural complexity, highlighting a mechanism that is unknown to behavioural ecologists despite being frequently considered by molecular biologists. We summarise indirect evidence that suggests behavioural CNE has occurred and outline how the hypothesis ...
Andrew M. Catherall‐Ostler, Tanmay Dixit   +1 more
wiley   +1 more source

Integrated control of vector-borne diseases of livestock--pyrethroids: panacea or poison?

, 2003
Tick- and tsetse-borne diseases cost Africa approximately US$4-5 billion per year in livestock production-associated losses. The use of pyrethroid-treated cattle to control ticks and tsetse promises to be an increasingly important tool to counter this ...
Coleman, Paul G, Eisler, Mark C, Machila, Noreen, Morton, John F, Torr, Stephen J   +4 more
core   +1 more source

Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast

Protein Science, Volume 34, Issue 7, July 2025.
Abstract In eukaryotes, cellular respiration takes place in the cristae of mitochondria. The mitochondrial inner membrane protein Mic60, a core component of the mitochondrial contact site and cristae organizing system, is crucial for the organization and stabilization of crista junctions and its associated functions.
Friederike M. C. Benning, Tristan A. Bell, Tran H. Nguyen, Della Syau, Louise B. Connell, Yi‐Ting Liao, Matthew P. Keating, Margaret Coughlin, Anja E. H. Nordstrom, Maria Ericsson, Corrie J. B. daCosta, Luke H. Chao   +11 more
wiley   +1 more source

Trypanosoma brucei infection protects mice against malaria.

PLoS Pathogens, 2019
Sleeping sickness and malaria are parasitic diseases with overlapping geographical distributions in sub-Saharan Africa. We hypothesized that the immune response elicited by an infection with Trypanosoma brucei, the etiological agent of sleeping sickness,
Margarida Sanches-Vaz, Adriana Temporão, Rafael Luis, Helena Nunes-Cabaço, António M Mendes, Sarah Goellner, Tânia Carvalho, Luisa M Figueiredo, Miguel Prudêncio   +8 more
doaj   +1 more source