Results 91 to 100 of about 58,854 (251)
Characterization and phylogenetic analysis of multidrug-resistant protein-encoding genes in Trypanosoma evansi isolated from buffaloes in Ngawi district, Indonesia [PDF]
Veterinary World, 2019 Background and Aim: Excessive use of trypanocidal drugs can lead to cases of drug resistance. Multiple cases of resistance have been widely reported for drugs such as isometamidium chloride and diminazene aceturate. These cases deserve serious attention,
Mohammad Mirza Nuryady +4 more
doaj +1 more source
, 2002 In most aerobic organisms hemoperoxidases play a major role in H(2)O(2)-detoxification, but trypanosomatids have been reported to lack this activity.
Kelly, John M +3 more
core +2 more sources
Lipid metabolism in Trypanosoma brucei [PDF]
Molecular and Biochemical Parasitology, 2010 Trypanosoma brucei membranes consist of all major eukaryotic glycerophospholipid and sphingolipid classes. These are de novo synthesized from precursors obtained either from the host or from catabolised endocytosed lipids. In recent years, substantial progress has been made in the molecular and biochemical characterisation of several of these lipid ...
Smith Terry K, Bütikofer Peter
openaire +2 more sources
Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex
Advanced Science, Volume 13, Issue 2, 9 January 2026.The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua +12 more
wiley +1 more source
Synthesis of biotinylated probes of artemisinin for affinity labeling
Data in Brief, 2015 In this data article, we described the synthetic routes to four biotinylated probes (2, 3, 4, and 5) of artemisinin and the associated experimental procedures. We also provided the physical data for the synthesized compounds.
Benetode Konziase
doaj +1 more source
On the extent and role of the small proteome in the parasitic eukaryote Trypanosoma brucei [PDF]
, 2014 Background: Although technical advances in genomics and proteomics research have yielded a better understanding of the coding capacity of a genome, one major challenge remaining is the identification of all expressed proteins, especially those less than ...
Butter, F. +5 more
core +2 more sources
Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.In vitro trypanocidal activity of a polyprenylated benzophenone‐enriched Brazilian red propolis extract (SEBz) and its major constituents, guttiferone E/xanthochymol (GUT/XAN) and oblongifolin B (OBL), exhibit in vitro trypanocidal activity against Trypanosoma cruzi, inducing ultrastructural damage with moderate cytotoxicity and no significant ...
Nicoli Dias Oliveira +9 more
wiley +1 more source
Trypanosoma brucei infection protects mice against malaria.
PLoS Pathogens, 2019 Sleeping sickness and malaria are parasitic diseases with overlapping geographical distributions in sub-Saharan Africa. We hypothesized that the immune response elicited by an infection with Trypanosoma brucei, the etiological agent of sleeping sickness,
Margarida Sanches-Vaz +8 more
doaj +1 more source
Onderstepoort Journal of Veterinary Research, 2004 The protective efficacy of isometamidium chloride (ISMM) and diminazene aceturate (DIM) against Trypanosoma brucei, Trypanosoma congolense and Trypanosoma vivax infections in cattle under a suppressed tsetse population was assessed in southeast Uganda.
J.W. Magona +3 more
doaj +1 more source