Results 141 to 150 of about 22,113 (163)

Kinetics of Methionine Transport and Metabolism by Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense

Archives of Biochemistry and Biophysics, 2000
Methionine is an essential amino acid for both prokaryotic and eukaryotic organisms; however, little is known concerning its utilization in African trypanosomes, protozoa of the Trypanosoma brucei group. This study explored the Michaelis-Menten kinetic constants for transport and pool formation as well as metabolic utilization of methionine by two ...
B, Goldberg, D, Rattendi, D, Lloyd, N, Yarlett, C J, Bacchi   +4 more
openaire   +2 more sources

Identification of Trypanosoma evansi, Trypanosoma equiperdum and Trypanosoma brucei brucei using repetitive DNA probes

Veterinary Parasitology, 1994
The phylogenetic relatedness of 15 stocks of Trypanosoma evansi, three stocks of Trypanosoma equiperdum and one stock of Trypanosoma brucei brucei was determined using Southern blot analysis of restriction enzyme digested DNA, probed with two repetitive DNA sequences from T. b. brucei.
Z Q, Zhang, T, Baltz
openaire   +2 more sources

cAMP signalling in Trypanosoma brucei

International Journal for Parasitology, 2001
Cyclic AMP was the first second messenger to be identified. After five decades of research, much is currently known about its biological functions and clinical implications. Several components of the cAMP signalling pathways, such as the G-protein coupled receptors and the phosphodiesterases, have become sensitive and specific drug targets for a host ...
T, Seebeck, K, Gong, S, Kunz, R, Schaub, T, Shalaby, R, Zoraghi   +5 more
openaire   +2 more sources

Genetic exchange in Trypanosoma brucei

Parasitology Today, 1990
The discovery of genetic exchange in African trypanosomes belonging to the Trypanosoma brucei group is an important development in our understanding of these organisms. Genetic exchange is a feature of major importance in relation to population structure and speciation.
A, Tait, C M, Turner
openaire   +2 more sources

Tubulin mRNAs of Trypanosoma brucei

Journal of Molecular Biology, 1986
The tubulin genes of Trypanosoma brucei are located in a single, tightly packed cluster of ten tandemly arranged alternating alpha and beta-genes. No tubulin genes are detected outside the clustered array. Therefore, the cluster can be assumed to be the locus of tubulin gene expression.
M, Imboden, B, Blum, T, DeLange, R, Braun, T, Seebeck   +4 more
openaire   +2 more sources

Stable transformation of Trypanosoma brucei

Molecular and Biochemical Parasitology, 1993
We have further analyzed parameters affecting stable transformation of Trypanosoma brucei. Linear DNA was much more efficient than circular DNA and in the vast majority of transformants analyzed the plasmid DNA had inserted into the chromosomes by homologous recombination.
ten Asbroek, A. L., Mol, C. A., Kieft, R., Borst, P.   +3 more
openaire   +3 more sources

Enzymatic Targets in Trypanosoma brucei

Current Protein & Peptide Science, 2016
One of the most neglected disease is the Sleeping sickness or Human African Trypanosomiasis (HAT), which is mostly restricted to poor regions of Africa. The disease is caused by parasitic infection with Trypanosoma brucei (T. brucei), and is acquired through the bite of the tsetse fly.
Luciana, Scotti, Francisco J B, Mendonça, Marcelo S, da Silva, Marcus T, Scotti   +3 more
openaire   +2 more sources

Glycolysis in Trypanosoma brucei

European Journal of Biochemistry, 1980
The possibility that the glycosomes present in the bloodstream form of Trypanosoma brucei [Opperdoes, F. R. and Borst, P. (1977) FEBS Lett. 80, 360–364] constitute a separate pool of glycolytic intermediates within the cell was investigated.In titrations of intact cells with digitonin, a differential activation of glycolytic enzymes was observed ...
N, Visser, F R, Opperdoes
openaire   +2 more sources

Self-fertilisation in Trypanosoma brucei

Molecular and Biochemical Parasitology, 1996
We have investigated whether Trypanosoma brucei can undergo self-fertilisation. A group of 27 metacyclic clones derived from the tsetse transmission of a mixture of two genetically marked stocks was analysed and 22 clones were observed to be of non-hybrid phenotype.
A, Tait, N, Buchanan, G, Hide, C M, Turner   +3 more
openaire   +2 more sources

The coatomer of Trypanosoma brucei

Molecular and Biochemical Parasitology, 2001
Coatomer is a multisubunit complex involved in trafficking of vesicles between the endoplasmatic reticulum and the Golgi apparatus. From sequence homologies, all seven subunits, alpha-, beta-, beta'-, gamma-, delta-, epsilon-, and zeta-COP, are encoded in the genome of Trypanosoma brucei.
A G, Maier, H, Webb, M, Ding, M, Bremser, M, Carrington, C, Clayton   +5 more
openaire   +2 more sources