Results 21 to 30 of about 22,113 (163)

P-type transport ATPases in Leishmania and Trypanosoma

Parasite, 2019
P-type ATPases are critical to the maintenance and regulation of cellular ion homeostasis and membrane lipid asymmetry due to their ability to move ions and phospholipids against a concentration gradient by utilizing the energy of ATP hydrolysis.
Meade John C.
doaj   +1 more source

VSGs Expressed during Natural T. b. gambiense Infection Exhibit Extensive Sequence Divergence and a Subspecies-Specific Bias towards Type B N-Terminal Domains

mBio, 2022
Trypanosoma brucei gambiense is the primary causative agent of human African trypanosomiasis (HAT), a vector-borne disease endemic to West and Central Africa.
Jaime So, Sarah Sudlow, Abeer Sayeed, Tanner Grudda, Stijn Deborggraeve, Dieudonné Mumba Ngoyi, Didier Kashiama Desamber, Bill Wickstead, Veerle Lejon, Monica R. Mugnier   +9 more
doaj   +1 more source

Population genetics of Trypanosoma brucei circulating in Glossina palpalis palpalis and domestic animals of the Fontem sleeping sickness focus of Cameroon

Parasites & Vectors, 2014
Background Human African Trypanosomiasis is still a public health threat in Cameroon. To assess Trypanosoma brucei strains circulating in the Fontem sleeping sickness focus, we conducted a genetic structure study using microsatellites to assess genotypes
Gustave Simo, Guy Roger Njitchouang, Tresor Tito Tanekou Melachio, Flobert Njiokou, Gerard Cuny, Asonganyi Tazoacha   +5 more
doaj   +1 more source

SUMOylation in Trypanosoma brucei

PeerJ, 2013
Small ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma brucei SUMO (Tb927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by temperature changes but were increased by severe oxidative stress.
Cornelia Andrea Klein, Dorothea Droll, Christine Clayton   +2 more
openaire   +3 more sources

Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A series of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline, and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives was designed, synthesised, and evaluated in vitro against three ...
Jean Guillon, Anita Cohen, Clotilde Boudot, Alessandra Valle, Vittoria Milano, Rabindra Nath Das, Aurore Guédin, Stéphane Moreau, Luisa Ronga, Solène Savrimoutou, Maxime Demourgues, Elodie Reviriego, Sandra Rubio, Sandie Ferriez, Patrice Agnamey, Cécile Pauc, Serge Moukha, Pascale Dozolme, Sophie Da Nascimento, Pierre Laumaillé, Anne Bouchut, Nadine Azas, Jean-Louis Mergny, Catherine Mullié, Pascal Sonnet, Bertrand Courtioux   +25 more
doaj   +1 more source

Anti-trypanosomal activity and DNA fingerprinting of fifteen Euphorbia species using ISSR and SCoT markers

Beni-Suef University Journal of Basic and Applied Sciences, 2021
Background Euphorbia is the largest genus in family Euphorbiaceae with a great biological and genetic diversity. The anti-trypanosomal activity of the crude extract of 15 Euphorbia species against Trypanosoma brucei brucei was carried out.
Seham S. El-Hawary, Nadia M. Lithy, Elham Amin, Sameh F. AbouZid, Rabab Mohammed   +4 more
doaj   +1 more source

Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis.

PLoS Pathogens, 2021
Human African Trypanosomiasis (HAT) has been responsible for several deadly epidemics throughout the 20th century, but a renewed commitment to disease control has significantly reduced new cases and motivated a target for the elimination of Trypanosoma ...
Alexandre Girard, Anneli Cooper, Samuel Mabbott, Barbara Bradley, Steven Asiala, Lauren Jamieson, Caroline Clucas, Paul Capewell, Francesco Marchesi, Matthew P Gibbins, Franziska Hentzschel, Matthias Marti, Juan F Quintana, Paul Garside, Karen Faulds, Annette MacLeod, Duncan Graham   +16 more
doaj   +1 more source

Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

International Journal for Parasitology: Drugs and Drug Resistance, 2015
Aquaglyceroporin-2 is a known determinant of melarsoprol–pentamidine cross-resistance in Trypanosoma brucei brucei laboratory strains. Recently, chimerization at the AQP2–AQP3 tandem locus was described from melarsoprol–pentamidine cross-resistant ...
Fabrice E. Graf, Nicola Baker, Jane C. Munday, Harry P. de Koning, David Horn, Pascal Mäser   +5 more
doaj   +1 more source

Golgi-associated phosphohydrolases in Trypanosoma brucei brucei

Molecular and Biochemical Parasitology, 1997
Various parasitic protozoa of the family Trypanosomatidae such as Crithidia spp. [1]; Trypanosoma cruzi [2]; Leishmania donovani [3] and salivarian trypanosomes [4-8] have been shown to contain acid phosphatase activity (EC.3.1.3.2, orthophosphoric-monoester phosphohydrolase activity).
Grab, D.J., Webster, P., Verjee, Y., Lonsdale-Eccles, J.   +3 more
openaire   +3 more sources

Structure of thioredoxin from Trypanosoma brucei brucei

FEBS Letters, 2003
The three‐dimensional structure of thioredoxin from Trypanosoma brucei brucei has been determined at 1.4 Å resolution. The overall structure is more similar to that of human thioredoxin than to any other thioredoxin structure. The most striking difference to other thioredoxins is the absence of a buried carboxylate behind the active site cysteines ...
Friemann, Rosmarie, Schmidt, Heide, Ramaswamy, S., Forstner, Michael, Krauth-Siegel, R.Luise, Eklund, Hans   +5 more
openaire   +2 more sources