Results 81 to 90 of about 69,743 (296)

Unstained Blood Smear Analysis: A Review of Rule‐Based, Machine Learning, and Deep Learning Techniques

Journal of Biophotonics, EarlyView.
Bright‐field images of unstained smears. (1) Sparse erythrocytes allow straightforward intensity‐ or phase‐based segmentation. (2) Overlapping cells blur boundaries, causing over‐ or under‐segmentation and lowering rule‐based accuracy, thus motivating overlap‐aware algorithms for reliable downstream feature extraction and classification. ABSTRACT Blood
Husnu Baris Baydargil, Thomas Bocklitz
wiley   +1 more source

Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity [PDF]

, 2009
Antigenic variation is an immune evasion strategy that has evolved in viral, bacterial and protistan pathogens. In the African trypanosome this involves stochastic switches in the composition of a variant surface glycoprotein (VSG) coat, using a massive ...
Marcello, Lucio, McCulloch, Richard, Morrison, Liam J.   +2 more
core   +1 more source

Purine-specific Nucleoside N-Ribohydrolase from Trypanosoma brucei brucei

Journal of Biological Chemistry, 1996
Trypanosomes have no de novo purine biosynthesis and thus depend upon salvage pathways to obtain purines for their metabolic pathways and for the biosynthesis of nucleic acids.
D. Parkin
semanticscholar   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Through the dark continent: African trypanosome development in the tsetse fly [PDF]

, 2013
African trypanosomes are unicellular flagellated parasites causing trypanosomiases in Africa, a group of severe diseases also known as sleeping sickness in human and nagana in cattle.
Rotureau, Brice, Van Den Abbeele, Jan
core   +4 more sources

Multiple evolutionary origins of Trypanosoma evansi in Kenya.

PLoS Neglected Tropical Diseases, 2017
Trypanosoma evansi is the parasite causing surra, a form of trypanosomiasis in camels and other livestock, and a serious economic burden in Kenya and many other parts of the world.
Christine M Kamidi, Norah P Saarman, Kirstin Dion, Paul O Mireji, Collins Ouma, Grace Murilla, Serap Aksoy, Achim Schnaufer, Adalgisa Caccone   +8 more
doaj   +1 more source

Modelling motility of Trypanosoma brucei. [PDF]

PLoS Comput Biol
African trypanosomiasis, or sleeping sickness, is a life-threatening disease caused by the protozoan parasite Trypanosoma brucei. The bloodstream form of T. brucei has a slender body with a relatively long active flagellum, which makes it an excellent swimmer.
Overberg FA, Jamshidi Khameneh N, Krüger T, Engstler M, Gompper G, Fedosov DA.   +5 more
europepmc   +4 more sources

Hypoxanthine uptake through a purine-selective nucleobase transporter in Trypanosoma brucei brucei procyclic cells is driven by protonmotive force.

European Journal of Biochemistry, 1997
The mechanism of purine nucleobase transport in procyclic cells of the protozoan parasite Trypanosoma brucei brucei was investigated. Hypoxanthine uptake at 22 degrees C was rapid and saturable, exhibiting an apparent Km of 9.3 +/- 2.0 microM and a Vmax ...
H. P. D. Koning, Simon M. Jarvis
semanticscholar   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, EarlyView.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source