Results 81 to 90 of about 68,686 (295)

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Lysosomal and non-lysosomal peptidyl hydrolases of the bloodstream forms of Trypanosoma brucei brucei.

European Journal of Biochemistry, 1987
African trypanosomes have thiol-dependent proteolytic activity that resembles some of the cathepsin-like activity found in mammalian lysosomes [Lonsdale-Eccles, J. D. & Mpimbaza, G. W. N. (1986) Eur. J. Biochem. 155, 469-473].
J. Lonsdale-Eccles, D. Grab
semanticscholar   +1 more source

Life and times:synthesis, trafficking, and evolution of VSG [PDF]

, 2014
Evasion of the acquired immune response in African trypanosomes is principally mediated by antigenic variation, the sequential expression of distinct variant surface glycoproteins (VSGs) at extremely high density on the cell surface.
Adung’a, Ali, Allen, Anitei, Banerjee, Bangs, Bangs, Barlowe, Barry, Blum, Boothroyd, Borst, Borst, Bridgen, Böhme, Chattopadhyay, Chung, Chung, Cordula Boehm, Cross, Cross, Donelson, El-Sayed, Engstler, Engstler, Ferguson, Ferguson, Field, Field, Field, Field, Field, Freymann, Gabernet-Castello, Gabernet-Castello, Goldshmidt, Grünfelder, Grünfelder, Hall, Heider, Izquierdo, Izquierdo, Jackson, Jackson, Jackson, Jeffries, Ka Fai Leung, Koumandou, Koumandou, Leung, Leung, Liu, Lord, Lustig, Lythgoe, Magez, Manna, Manna, Manthri, Mark C. Field, Mayor, McConnell, McConville, McLintock, Mehlert, Morgan, Morrison, Nagamune, Natesan, Nolan, Overath, Pal, Pal, Parodi, Paul T. Manna, Radwanska, Schwede, Senthil Kumar Natesan, Sevova, Seyfang, Sheader, Silverman, Silverman, Smith, Smith, Thomas, Triggs, Udenfriend, Vickerman, Wang, Wang, Warren, Wickner, Ziegelbauer   +93 more
core   +2 more sources

Aminoisothiazolamides, a new class of potent inhibitors of lysyl‐tRNA synthetase

Pest Management Science, EarlyView.
The present work covers a series of novel herbicidal lead structures that possess an aminoisothiazolamide scaffold as a structural key feature. Lysyl‐tRNA synthetase 1 (KRS1) was identified as the biochemical mode‐of‐action. Based on optimized and tailored synthetic approaches, a broader SAR study was carried out delivering some lead structures that ...
David Bernier, David M Barber, Guido Bojack, Birgit Bollenbach‐Wahl, Luke Churchman, Uwe Döller, Tyler Fahrenhorst‐Jones, Jörg Freigang, Elmar Gatzweiler, Claudia Hartfiel, Caroline Hilmi, Yoann Huet, Bernd Laber, Gudrun Lange, Stephanie Lee, Virginie Lempereur, Marc Mosrin, Thomas Müller, China M Payne, Olaf Peters, Luka Posa, Shaun Rees, Anna M Reingruber, Jullien Rey, Jörg Tiebes, Karen Tilmant, Jens Frackenpohl   +26 more
wiley   +1 more source

Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation [PDF]

, 2016
Survival of Trypanosoma brucei depends upon switches in its protective Variant Surface Glycoprotein (VSG) coat by antigenic variation. VSG switching occurs by frequent homologous recombination, which is thought to require locus-specific initiation. Here,
Aresta-Branco, Bachrati, Barry, Barry, Benmerzouga, Bergink, Bermejo, Bernstein, Berriman, Bianchi, Boothroyd, Brookes, Burkard, Cahoon, Cejka, Cross, Cross, Dobson, Dreesen, Fairman-Williams, Falaschi, Fasching, Glover, Glover, Glover, Glover, Glover, Groth, Guizetti, Haaf, Haber, Hall, Hartley, Hertz-Fowler, Hicks, Hickson, Hickson, Higgins, Horn, Hovel-Miner, Im, Imamura, Ira, Jehi, Kassem, Kelly, Kim, Kim, Kitano, Klar, Kusumoto, Landeira, Langmead, Lee, Linder, Livak, Lundin, Lydeard, Mankouri, Marcello, Marques, McCulloch, McCulloch, McKean, Merrikh, Mimitou, Morozov, Morrison, Mugnier, Mullen, Nguyen, Obergfell, Palmer, Parvathaneni, Povelones, Proudfoot, Reiter, Renkawitz, Rhind, Roth, Rudenko, Rudenko, Rudenko, Sheader, Siegel, Spell, Tarsounas, Tiengwe, Trenaman, Turner, Umezu, Wickstead, Wyatt, Xu, Zhu   +94 more
core   +2 more sources

Structure of thioredoxin from Trypanosoma brucei brucei

FEBS Letters, 2003
The three‐dimensional structure of thioredoxin from Trypanosoma brucei brucei has been determined at 1.4 Å resolution. The overall structure is more similar to that of human thioredoxin than to any other thioredoxin structure. The most striking difference to other thioredoxins is the absence of a buried carboxylate behind the active site cysteines ...
Heide Schmidt, Rosmarie Friemann, R. Luise Krauth-Siegel, Hans Eklund, S. Ramaswamy, Michael Forstner   +5 more
openaire   +3 more sources

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, EarlyView.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source

Purine-specific Nucleoside N-Ribohydrolase from Trypanosoma brucei brucei

Journal of Biological Chemistry, 1996
Trypanosomes have no de novo purine biosynthesis and thus depend upon salvage pathways to obtain purines for their metabolic pathways and for the biosynthesis of nucleic acids.
D. Parkin
semanticscholar   +1 more source

The trypanosomal transferrin receptor of trypanosoma brucei : a review [PDF]

, 2019
Iron is an essential element for life. Its uptake and utility requires a careful balancing with its toxic capacity, with mammals evolving a safe and bio-viable means of its transport and storage. This transport and storage is also utilized as part of the
Kariuki, Christopher K., Stijlemans, Benoit, Magez, Stefan   +2 more
core   +2 more sources

Stress in dipteran insects mass‐reared for sterile insect technique applications

Insect Science, EarlyView.
The connections between biotic and abiotic stress affecting mass‐reared dipteran insects and the associated stress and immunological responses. Numbers indicate the order in which the topics are discussed in this review. Abstract Stress may be viewed as the disturbance of homeostasis of an organism.
Caroline K. Mirieri, Vera I.D. Ros, Adly M.M. Abd‐Alla, Monique M. van Oers   +3 more
wiley   +1 more source