Results 91 to 100 of about 28,049 (192)

Ultrastructural expansion microscopy reveals unexpected levels of glycosome heterogeneity in African trypanosomes

Journal of Microscopy, Volume 301, Issue 2, Page 222-240, February 2026.
Abstract Kinetoplastid parasites include several species. Trypanosoma brucei causes African sleeping sickness in humans and a wasting disease nagana in livestock. Trypanosoma cruzi is the causative agent of Chagas disease and Leishmania species cause leishmaniasis, which can present with visceral, cutaneous, or mucocutaneous symptoms.
Heidi Anderson, Rhonda Reigers Powell, Meredith Teilhet Morris   +2 more
wiley   +1 more source

The challenging problem of disease staging in human African trypanosomiasis (sleeping sickness): a new approach to a circular question [PDF]

, 2017
Human African trypanosomiasis (HAT), also known as sleeping sickness, puts millions of people at risk in sub-Saharan Africa and is a neglected parasitic disease that is almost always fatal if untreated or inadequately treated. HAT manifests itself in two
Gettinby, George, Kennedy, Peter G.E., Njamnshi, Alfred K.   +2 more
core   +1 more source

Trypanocidal Effects of Polyprenylated Benzophenone Enriched Brazilian Red Propolis Extract and Its Isolated Constituent

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
In vitro trypanocidal activity of a polyprenylated benzophenone‐enriched Brazilian red propolis extract (SEBz) and its major constituents, guttiferone E/xanthochymol (GUT/XAN) and oblongifolin B (OBL), exhibit in vitro trypanocidal activity against Trypanosoma cruzi, inducing ultrastructural damage with moderate cytotoxicity and no significant ...
Nicoli Dias Oliveira, Mariana Cintra Pagotti, Lucas Antonio de Lima Paula, Mariana Zaramello Paixão, Daiane Albino dos Santos, Renata Faleiros de Freitas, Sérgio Ricardo Ambrósio, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Lizandra Guidi Magalhães   +9 more
wiley   +1 more source

Through the dark continent: African trypanosome development in the tsetse fly [PDF]

, 2013
African trypanosomes are unicellular flagellated parasites causing trypanosomiases in Africa, a group of severe diseases also known as sleeping sickness in human and nagana in cattle.
Rotureau, Brice, Van Den Abbeele, Jan
core   +4 more sources

First PATTEC consultative workshop on strategies, technical advances and partnerships in tsetse and trypanosomosis management

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2015
Tsetse and trypanosomiasis (T&T) remain endemic in many countries, although many efforts have been made in recent decades within the framework of the Pan-African Tsetse and Trypanosomiasis Eradication Campaign (PATTEC) Initiative, and despite progress ...
Hassane H. Mahamat
doaj   +1 more source

Field evaluation of the CATT/Trypanosoma brucei gambiense on blood-impregnated filter papers for diagnosis of human African trypanosomiasis in southern Sudan. [PDF]

, 2002
Most Human African Trypanosomiasis (HAT) control programmes in areas endemic for Trypanosoma brucei gambiense rely on a strategy of active mass screening with the Card Agglutination Test for Trypanosomiasis (CATT)/T. b. gambiense.
Adams, K, Bovier, P A, Büscher, P, Chappuis, F, Godineau, V, Hwang, S Y, Magnus, E, Pittet, A   +7 more
core   +2 more sources

Management of trypanosomiasis and leishmaniasis [PDF]

, 2012
<p>Background: The current treatments for human African trypanosomiasis (HAT), Chagas disease and leishmaniasis (collectively referred to as the kinetoplastid diseases) are far from ideal but, for some, there has been significant recent progress ...
Alsford, Alvar, Alvar, Barrett, Barrett, Ben Salah, Berman, Bern, Brun, Brun, Burri, Chappuis, Coura, Croft, Croft, El-Sayed, Frearson, Hailu, Jacobs, Jacobs, Le Loup, Lessa, M. P. Barrett, Miranda-Verastegui, Paine, Pinazo, Priotto, Rassi, Reithinger, Rodgers, S. L. Croft, Stuart, Sundar, Sundar, Sundar, Sundar, Torreele, Vanhollebeke, Vincent, Voogd   +39 more
core   +2 more sources

Characterization of Trypanosoma brucei gambiense variant surface glycoprotein LiTat 1.5 [PDF]

, 2012
At present, all available diagnostic antibody detection tests for Trypanosoma brucei gambiense human African trypanosomiasis are based on predominant variant surface glycoproteins (VSGs), such as VSG LiTat 1.5. During investigations aiming at replacement
Büscher, P., Guisez, Y., Lejon, V., Rogé, S., Van Nieuwenhove, L.   +4 more
core   +1 more source

Chemotherapy of Human African Trypanosomiasis

Interdisciplinary Perspectives on Infectious Diseases, 2009
Human Africa trypanosomiasis is a centuries-old disease which has disrupted sub-Saharan Africa in both physical suffering and economic loss. This article presents an update of classic chemotherapeutic agents, in use for >50 years and the recent ...
Cyrus J. Bacchi
doaj   +1 more source

Iloprost treatment enhanced IL-4 signalling to reverse trypanosome-induced cognitive deficits and suppressed neuroinflammation in mice

International Journal of Infectious Diseases
Introduction: The development of neurological disorders following trypanosome brain infection has been recognised for over a century. However, an ongoing endeavour persists to comprehensively understand the neurocognitive and neuropathological changes ...
Dr Oluwashola Olaolu, Professor Hajierah Davids, Professor Gill. B Dealtry, Miss Oluwatoyin Morenikeji, Dr Emmanuel T Obishakin, Mrs Binta Iliayasu, Dr Azeez Idris, Dr Chris Duyilemi Ajonijebu   +7 more
doaj   +1 more source