Results 21 to 30 of about 24,405 (100)

Pandemic Prevention Paradigms: Understanding Global Health Governance

Public Health Challenges, Volume 4, Issue 2, June 2025.
One Health is an emerging area of integrative studies and interventions aimed at preventing zoonotic diseases by addressing human, animal, and environmental interactions. A fundamental aspect of the concept is understanding how these interactions influence health outcomes among humans, animals, and ecosystems. Developed initially to respond to the need
Soheil Sadr, Cinzia Santucciu, Valentina Chisu, Narges Lotfalizadeh, Shakiba Nazemian, Negin Esfandiari, Ashkan Hajjafari, Helia Sepahvand, Abbas Rahdar, Sadanand Pandey, Hassan Borji   +10 more
wiley   +1 more source

Perceived Threat of Zoonotic Infections in Abattoir Workers in the Tamale Metropolis of Ghana: An Assessment of Knowledge, Attitudes and Practices

Public Health Challenges, Volume 4, Issue 2, June 2025.
Most abattoir workers (90.2%) knew that humans can get zoonotic diseases from the animals they handle. However, some respondents believe that witchcraft (20.0%), curses (20.8%) and supernatural powers (18.0%) cause zoonotic diseases. ABSTRACT Background Abattoir workers are more prone to acquiring zoonotic diseases.
Benjamin Nuhu Tingbani, Ezekiel Kofi Vicar, Stephen Apanga, Elijah Bisuman Sambian, Samuel Tamanyian Suuk, Edmond Nakinpaak Biibantib, Williams Walana   +6 more
wiley   +1 more source

Regulator experiences of trials during Ebola epidemics in Sierra Leone, Guinea, and the Democratic Republic of the Congo

Tropical Medicine &International Health, Volume 30, Issue 6, Page 539-546, June 2025.
Abstract Introduction During the 2014–2016 Ebola epidemic in West Africa and the Ebola outbreaks between 2018 and 2020 in the Democratic Republic of Congo, vaccines and other tools for prevention and treatment had to be taken through trials in exceptional circumstances using accelerated processes.
Kambale Kasonia, Frank Baiden, Frédéric Le Marcis, Bruno Lapika, Joel Kiyulu, Henri Kimina, Freddy Bikioli, Fanny Attas, Anthony Mansaray, Rose Burns, Elysée Nouvet, Séverine Thys, Antea Paviotti, Daniela Manno, Mukeh Kenneth Fahnbulleh, Bailah Leigh, Mohamed Samai, Brian Greenwood, Shelley Lees, Patrick Mitashi Mulopo, Deborah Watson‐Jones   +20 more
wiley   +1 more source

Eflornithine is Safer Than Melarsoprol for the Treatment of Second-Stage Trypanosoma Brucei Gambiense Human African Trypanosomiasis. [PDF]

, 2005
Patients with second-stage human African trypanosomiasis treated with eflornithine (n = 251) in 2003 in Kiri, southern Sudan, had an adjusted relative risk of death of 0.2 and experienced significantly fewer cutaneous and neurological adverse effects ...
A. Meussen, Brun, F. Chappuis, K. Stietenroth, Legros, Milord, Milord, N. Udayraj, P. A. Bovier, P  pin, Schmid   +10 more
core   +2 more sources

Risk Evaluation and Mitigation Strategies for Newly Detected Mysterious Dinga Dinga Virus Infection in Africa: A Narrative Review

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aims The Dinga Dinga Virus (DDV) has emerged as a mysterious disease gripping women in Uganda, raising alarm due to its unusual and distressing “dancing” like symptoms. These symptoms, characterized by involuntary movements resembling dance, suggest possible neurological involvement, though the exact pathogen remains ...
Sabrina Sharmin, Salsabil Islam, Md. Aminul Haque, Md. Rabiul Islam   +3 more
wiley   +1 more source

Tick Species Infesting Livestock in Three Bioclimatic Areas of Senegal: Bioecology, Prevalence of Tick Infestation, Associated Categorical Factors and Crimean‐Congo Haemorrhagic Fever Virus Infection

Veterinary Medicine and Science, Volume 11, Issue 3, May 2025.
Ticks were collected between October 2020 and November 2022, from cattle, goats and sheep in the Sahelian, Sudano‐Sahelian and Sudanian zones, and tested for CCHFV infection. A total of 3632 animals were examined and 35.3% (95% CI: 33.8–36.9) found tick‐infested.
Aliou Khoule, Déthié Ngom, Mouhamet Faye, Ousseynou Sene, Aminata Badji, Elhadji Ndiaye, Gamou Fall, Ibrahima Dia, Mawlouth Diallo, Diawo Diallo   +9 more
wiley   +1 more source

Integrated cost-benefit analysis of tsetse control and herd productivity to inform control programs for animal African trypanosomiasis [PDF]

, 2018
Animal African trypanosomiasis (AAT) and its tsetse vector are responsible for annual losses estimated in billions of US dollars ($). Recent years have seen the implementation of a series of multinational interventions.
Chilongo, K, Fauron, A, Gilbert, W, Guitian, J, Holt, H R, Meyer, A, Mumba, C, Oumarou,, F   +7 more
core   +1 more source

Exploring Aspartate Transcarbamoylase: A Promising Broad‐Spectrum Target for Drug Development

ChemBioChem, Volume 26, Issue 7, April 1, 2025.
Pyrimidine biosynthesis is a pivotal process shared by both eukaryotes and prokaryotes. This review examines the applications and advantages of a series of inhibitors specifically designed to target aspartate transcarbamylase within the de novo biosynthetic pathway of the malarial parasite.
Siyao Chen, Queenie Mondile, XiaoChen Du, Chao Wang, Mayur Mukim, Carsten Wrenger, Alexander S. S. Dömling, Özlem Tastan Bishop, Matthew R. Groves   +8 more
wiley   +1 more source

Spatially and genetically distinct African trypanosome virulence variants defined by host interferon-g response [PDF]

, 2007
We describe 2 spatially distinct foci of human African trypansomiasis in eastern Uganda. The Tororo and Soroti foci of <i>Trypanosoma brucei rhodesiense</i> infection were genetically distinct as characterized by 6 microsatellite and 1 ...
Anneli Cooper, Annette MacLeod, Bakhiet M, Bancroft GJ, Cattand P, Hertz CJ, Hunter CA, Jeremy M. Sternberg, Liam Morrison, Lindsay Sweeney, Lorna MacLean, Martin Odiit, Morrison LJ, Page RDM, Peter G. E. Kennedy, Schleifer KW, Schleifer KW, Sternberg JM, Woo PT, World Health Organization   +19 more
core   +1 more source

From fat storage to immune hubs: the emerging role of adipocytes in coordinating the immune response to infection

The FEBS Journal, Volume 292, Issue 8, Page 1868-1883, April 2025.
Traditionally, adipocytes have been viewed as energy storage units, which upregulate inflammatory factors in response to obesity. However, emerging evidence demonstrates that adipocytes are highly responsive to systemic infection, and upregulate cytokines and antimicrobial compounds in response.
Matthew C. Sinton, Shingo Kajimura
wiley   +1 more source