Results 51 to 60 of about 28,232 (207)
Therapeutic Strategies against Leishmania and Trypanosoma
Pathogens, 2023 Human African trypanosomiasis (also known as sleeping sickness, with Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense as etiological agents), American trypanosomiasis (also known as Chagas disease, with Trypanosoma cruzi as the etiological
André L. S. Santos +5 more
doaj +1 more source
Spatially and genetically distinct African trypanosome virulence variants defined by host interferon-g response [PDF]
, 2007 We describe 2 spatially distinct foci of human African trypansomiasis in eastern Uganda. The Tororo and Soroti foci of <i>Trypanosoma brucei rhodesiense</i> infection were genetically distinct as characterized by 6 microsatellite and 1 ...
Anneli Cooper +19 more
core +1 more source
Toward the elimination of HAT in Nigeria: leaving no community behind
International Journal of Infectious DiseasesObjectives: Sleeping sickness, also known as human African trypanosomiasis (HAT), is a tsetse fly-borne neglected tropical disease that affects underserved rural communities in sub-Saharan Africa.
Rolayo T. Emmanuel +2 more
doaj +1 more source
Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis [PDF]
, 2017 Although Trypanosoma brucei spp. was first detected by Aldo Castellani in CSF samples taken from sleeping sickness patients over a century ago there is still a great deal of debate surrounding the timing, route and effects of transmigration of the ...
Bradley, Barbara +2 more
core +1 more source
Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies
Journal of Applied Entomology, EarlyView.ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi +4 more
wiley +1 more source
, 2013 Human African trypanosomiasis or sleeping sickness is a neglected tropical disease that affects populations in sub-Saharan Africa. The disease is caused by infection with the gambiense and rhodesiense subspecies of the extracellular parasite Trypanosoma brucei, and is transmitted to humans by bites of infected tsetse flies.
Lejon, Veerle +2 more
openaire +3 more sources
Exploring 6‐Hydroxy‐3‐Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi
ChemMedChem, Volume 21, Issue 9, 14 May 2026.New therapies are urgently needed for Chagas disease, and screening of 6‐hydroxy‐3‐aryl/heteroarylcoumarin derivatives identified highly selective compounds with potent activity against T. cruzi. In particular, derivative 1f showed submicromolar trypomastigote potency, dual‐stage activity, and inhibition of amastigote‐to‐trypomastigote differentiation,
C. N. Pereira +7 more
wiley +1 more source
, 2010 African trypanosomes continue to present major public and livestock health problems in sub-Saharan African, typically in rural communities with limited access to diagnosis and treatment. Over the past 50 years, a tractable set of laboratory models for this infection has led to an appreciation of the immunological, cellular and molecular subtleties of ...
Sternberg, Jeremy M +2 more
+4 more sources
Case of Nigeria-Acquired Human African Trypanosomiasis in United Kingdom, 2016
Emerging Infectious Diseases, 2017 Human African trypanosomiasis has not been reported in Nigeria since 2012. Nevertheless, limitations of current surveillance programs mean that undetected infections may persist.
Akish Luintel +6 more
doaj +1 more source
Counterflow dielectrophoresis for trypanosome enrichment and detection in blood [PDF]
, 2012 Human African trypanosomiasis or sleeping sickness is a deadly disease endemic in sub-Saharan Africa, caused by single-celled protozoan parasites. Although it has been targeted for elimination by 2020, this will only be realized if diagnosis can be ...
A Carlsson +19 more
core +1 more source