Results 61 to 70 of about 28,232 (207)

Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review

American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 993-1003, May 2026.
ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle, Sara M. Sarasua, Tracy Lowe, Christopher L. Farrell, Luigi Boccuto, Charles Schwartz, Anthony E. Pegg, Angela Peron, Victor Faundes, Mythily Ganapathi, Wendy K. Chung, Alban Ziegler, Floris Hofstede, Clément Prouteau, Katharina Steindl, Colleen Olson, Orrin Devinsky, Teresa L. Mastracci, Robert A. Casero Jr., Tracy Murray Stewart, Susan Gilmour, Teri Koerner, Mary Jo Kutler, Surender Rajasekaran, Julianne Michael, André S. Bachmann, Caleb P. Bupp   +26 more
wiley   +1 more source

Challenges facing the elimination of sleeping sickness in west and central Africa: sustainable control of animal trypanosomiasis as an indispensable approach to achieve the goal

Parasites & Vectors, 2015
African trypanosomiases are infectious diseases caused by trypanosomes. African animal trypanosomiasis (AAT) remains an important threat for livestock production in some affected areas whereas human African trypanosomiasis (HAT) is targeted for ...
Gustave Simo, Jean Baptiste Rayaisse
doaj   +1 more source

Whole-genome sequencing of trypanosoma brucei reveals introgression between subspecies that is associated with virulence [PDF]

, 2013
Human African trypanosomiasis is caused by two subspecies of Trypanosoma brucei. Trypanosoma brucei rhodesiense is found in East Africa and frequently causes acute disease, while Trypanosoma brucei gambiense is found in West Africa and is associated with
Apted, Balmer, Balmer, Berriman, Brun, Cottle, Fakhar, Gibson, Gibson, Grigg, Hertz-Fowler, Hide, Hoare, Huson, Jackson, Jamonneau, Kristjanson, Langmead, Li, Maclean, MacLeod, Masumu, Mehlitz, Morrison, Ormerod, Picozzi, Rozen, Savill, Seed, Simarro, Smith, Stevens, Thorvaldsdóttir, Truc, Tyler, Vincent   +35 more
core   +5 more sources

Occurrence and Public Health Implications of Brucella Abortus and Antimicrobial Residues in Raw Cow Milk in Bukombe District, Tanzania

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Poor husbandry practices in Bukombe District accelerate diseases in livestock and indiscriminate uses of antimicrobials. Cow abortions, raw cow placenta and aborted fetuses feeding dogs, communal grazing and watering and introduction of new animals predict brucellosis in the herd.
Makoye Mhozya, Mwalimu Julius K, Hezron Emmanuel Nonga   +2 more
wiley   +1 more source

Reemergence of Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense, Ethiopia

Emerging Infectious Diseases
We report 4 cases of human African trypanosomiasis that occurred in Ethiopia in 2022, thirty years after the last previously reported case in the country. Two of 4 patients died before medicine became available.
Adugna Abera, Tihitina Mamecha, Ebise Abose, Belachew Bokicho, Agune Ashole, Tesfahun Bishaw, Abinet Mariyo, Buzayehu Bogale, Haileyesus Terefe, Henok Tadesse, Mahlet Belachew, Hailemariam Difabachew, Araya Eukubay, Solomon Kinde, Abraham Ali, Feyesa Regasa, Fikre Seife, Zeyede Kebede, Mesfin Wossen, Getachew Tollera, Mesay Hailu, Nigus Manaye, Nick Van Reet, Gerardo Priotto, Johan van Griensven, Myrthe Pareyn, Geremew Tasew   +26 more
doaj   +1 more source

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe, Vishal Satikuvar, Tanjia M. Syeda, Monica Cal, Pascal Mäser, Marcel Kaiser, Hachemi Kadri   +6 more
wiley   +1 more source

Green fluorescent diamidines as diagnostic probes for trypanosomes [PDF]

, 2014
LED fluorescence microscopy offers potential benefits to the diagnosis of human African trypanosomiasis, as well as to other aspects of diseases management, such as detection of drug resistant strains.
Arvind Kumar, Bailey, Baker, Barrett, Bieler, Bridges, Carter, Chappuis, David W. Boykin, de Koning, Federica Giordani, Hanscheid, Jones, Keiser, Lanteri, Manoj Munde, Mathis, Mathis, Matovu, Michael P. Barrett, Minion, Mohamed A. Ismail, Paine, Steingart, Stewart, Vincent, W. David Wilson, Wilson   +27 more
core   +1 more source

Phytochemical Diversity, Nutritional Values, and Biological Properties of Halopithys incurva (Hudson) Batters, 1902

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Halopithys incurva is a red macroalga distributed across the Mediterranean Sea and North‐East Atlantic, with occasional reports from the Indian Ocean. It exhibits a rich chemical diversity, including isoflavones, bromophenols, MAAs, pigments, phycobiliproteins, primary metabolites, and neuroactive compounds.
Youssra Aalilou, Abdelhakim Bouyahya, Kaoutar Benrahou, Mustapha Hassoun, Hanaa Moussa, Issam Ameziane El Hassani, Waleed Al Abdulmonem, Learn‐Han Lee, Gokhan Zengin, My El Abbes Faouzi   +9 more
wiley   +1 more source

Availability and affordability of treatment for Human African Trypanosomiasis. [PDF]

, 2001
Human African Trypanosomiasis (HAT) is a re-emerging disease whose usual treatments are becoming less efficient because of the increasing parasite resistance.
Etchegorry, M, Helenport, J, Jannin, J, Legros, D, Pecoul, B   +4 more
core   +3 more sources

Mystery Disease X Outbreak in the Democratic Republic of the Congo: A Narrative Review of Epidemiological Patterns and Response Challenges

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims An unknown disease known as Disease X first surfaced in the Panzi Health Zone, Kwango Province, Democratic Republic of the Congo (DRC), towards the end of 2024. It mainly affected children under the age of five. The clinical characteristics and of the outbreak are examined in this review.
Muhammad Shaheer Bin Faheem, Muhammad Haroon‐Ul‐Rasheed, Sumaya Samadi   +2 more
wiley   +1 more source