Results 61 to 70 of about 12,325 (181)
A murine model of Trypanosoma brucei-induced myocarditis and cardiac dysfunction
Microbiology SpectrumTrypanosoma brucei is a protozoan parasite that causes human and animal African trypanosomiases (HAT and AAT). Cardiac symptoms are commonly reported in HAT patients, and intracardiac parasites with accompanying myocarditis have been observed in both ...
Nathan P. Crilly +7 more
doaj +1 more source
Anilinoquinoline based inhibitors of trypanosomatid proliferation.
PLoS Neglected Tropical Diseases, 2018 We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum.
Lori Ferrins +11 more
doaj +1 more source
Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review
American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 993-1003, May 2026.ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle +26 more
wiley +1 more source
The Burden of Human African Trypanosomiasis
PLoS Neglected Tropical Diseases, 2008 Human African trypanosomiasis (HAT, or sleeping sickness) is a protozoan parasitic infection caused by Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense. These are neglected tropical diseases, and T.b. rhodesiense HAT is a zoonosis. We review current knowledge on the burden of HAT in sub-Saharan Africa, with an emphasis on the disability ...
Fèvre, Eric M. +3 more
openaire +6 more sources
Tick‐borne pathogen interactions enhance transmission in cattle and ticks in Ogun, Nigeria
Ecosphere, Volume 17, Issue 5, May 2026.Abstract Tick‐borne diseases (TBDs) pose a major public health concern in tropical regions, where co‐infections and pathogen interactions complicate disease control. Understanding how these interactions vary across vertebrate hosts and tick vectors, and their impact on disease transmission, is crucial for developing effective intervention strategies ...
Foluke Adedayo Akande +15 more
wiley +1 more source
Pharmacological Approaches to Antitrypanosomal Chemotherapy
Memorias do Instituto Oswaldo Cruz, 1999 There is an urgent need for new drugs for the chemotherapy of human African trypanosomiasis, Chagas disease and leishmaniasis. Progress has been made in the identification and characterization of novel drug targets for rational chemotherapy and ...
Simon L Croft
doaj +1 more source
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2015 Tsetse and trypanosomiasis (T&T) remain endemic in many countries, although many efforts have been made in recent decades within the framework of the Pan-African Tsetse and Trypanosomiasis Eradication Campaign (PATTEC) Initiative, and despite progress ...
Hassane H. Mahamat
doaj +1 more source
Parasite Immunology, 2011 Morrison, L J; id_orcid 0000-0002-8304-9066 +1 more
openaire +3 more sources
Chemotherapy of Human African Trypanosomiasis
Interdisciplinary Perspectives on Infectious Diseases, 2009 Human Africa trypanosomiasis is a centuries-old disease which has disrupted sub-Saharan Africa in both physical suffering and economic loss. This article presents an update of classic chemotherapeutic agents, in use for >50 years and the recent ...
Cyrus J. Bacchi
doaj +1 more source
International Journal of Infectious DiseasesIntroduction: The development of neurological disorders following trypanosome brain infection has been recognised for over a century. However, an ongoing endeavour persists to comprehensively understand the neurocognitive and neuropathological changes ...
Dr Oluwashola Olaolu +7 more
doaj +1 more source