Results 61 to 70 of about 28,049 (192)

Stunning Intricacies of RNA Editing Complexes RECC, RESC, and REH2C: Functional Organization, Developmental Regulation, and Evolutionary History in Kinetoplastid Protists

WIREs RNA, Volume 17, Issue 2, March/April 2026.
U‐indel RNA editing targets mRNA:gRNA duplexes through three key complexes that collectively govern assembly, specificity, catalysis, and developmental regulation. Modern tools, including artificial intelligence, analyze the organization, dynamics, and evolution of the remarkable holo‐editosome, opening new avenues in RNA biology and therapy.
Suzanne M. McDermott, Julius Lukeš, Laurie K. Read, Reza Salavati, Achim Schnaufer, Sara L. Zimmer, Jason Carnes, Alasdair Ivens, Naghmeh Poorinmohammad, Nicholas J. Savill, Dave Speijer, Ken Stuart, Kristína Záhonová, Poorya Mirzavand Borujeni, Zihao Chen, Cody Goode, Sunil Kumar Sharma, Lars O’Hara, Jorge Cruz‐Reyes   +18 more
wiley   +1 more source

Counterflow dielectrophoresis for trypanosome enrichment and detection in blood [PDF]

, 2012
Human African trypanosomiasis or sleeping sickness is a deadly disease endemic in sub-Saharan Africa, caused by single-celled protozoan parasites. Although it has been targeted for elimination by 2020, this will only be realized if diagnosis can be ...
A Carlsson, F Chappuis, FH Labeed, J Vykoukal, JA Rodriguez, KS Ralston, M Jacob, M Murray, MP Barrett, NG Green, P Gascoyne, SC Welburn, SH Holm, U Kim, WH Lumsden, WT Freeman, X-B Wang, XB Wang, Y Huang, ZK Njiru   +19 more
core   +1 more source

Prevalence of Human and Animal African Trypanosomiasis in Nigeria: A Scoping Review

Parasitologia
African trypanosomiasis is a protozoan disease that affects both humans and animals. Human African Trypanosomiasis (HAT) is a Neglected Tropical Disease targeted for elimination in 2030.
Chinwe Chukwudi, Elizabeth Odebunmi, Chukwuemeka Ibeachu   +2 more
doaj   +1 more source

Practical and Ethical Issues in Big Data and Machine Learning Forecasts of Zambian Community Forestry Engagement

Conservation Letters, Volume 19, Issue 2, March/April 2026.
ABSTRACT Approaches integrating geospatial “big data” and machine learning will likely be increasingly used to predict conservation‐related human behavior, such as patterns of local engagement, in socioecological systems. Yet, few studies evaluate both the technical and ethical aspects of such applications.
Thomas Pienkowski, Morena Mills, Matt Clark, Kaala Moombe, Henry Chilufya, Alexandros Sfyridis, Jocelyne Shimin Sze, Erik Olsson, Andreas Christ Sølvsten Jørgensen   +8 more
wiley   +1 more source

Green fluorescent diamidines as diagnostic probes for trypanosomes [PDF]

, 2014
LED fluorescence microscopy offers potential benefits to the diagnosis of human African trypanosomiasis, as well as to other aspects of diseases management, such as detection of drug resistant strains.
Arvind Kumar, Bailey, Baker, Barrett, Bieler, Bridges, Carter, Chappuis, David W. Boykin, de Koning, Federica Giordani, Hanscheid, Jones, Keiser, Lanteri, Manoj Munde, Mathis, Mathis, Matovu, Michael P. Barrett, Minion, Mohamed A. Ismail, Paine, Steingart, Stewart, Vincent, W. David Wilson, Wilson   +27 more
core   +1 more source

A mathematical model for evaluating the role of trypanocide treatment of cattle in the epidemiology and control of Trypanosoma brucei rhodesiense and T. b. gambiense sleeping sickness in Uganda

Parasite Epidemiology and Control, 2019
Background: Human and animal African trypanosomiases impose a large economic and health burden in their endemic regions. Large strides have been made in the control of human African trypanosomiasis (HAT), yet these efforts have largely focused on the non-
Julianne Meisner, Ruanne V. Barnabas, Peter M. Rabinowitz   +2 more
doaj   +1 more source

Influence de la trypanosomose sur la reproduction des bovins en Afrique [PDF]

Tropicultura, 2000
The Influence of African Animal Trypanosomiasis on Reproduction of Cattle in Africa. The main effects of African animal Trypanosomiasis on reproduction of cattle have been reviewed.
Zecchini, M., Kageruka, P., De Deken, R.
doaj  

Cytotoxicity and Antimicrobial Activity of GaMF1 Analogs

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
GaMF1 is a reported, highly potent inhibitor of mycobacterial ATP synthase. Structural modification of this scaffold significantly changes biological activity. We present GaMF1 analogues with strong antiparasitic effects, potential antiproliferative properties, and discuss the selectivity limitations of the parent compound and its analogues.
Jan Chasák, Petr Vyvlečka, Ivan Nemec, An Matheeussen, Natascha Van Pelt, Paul Cos, Guy Caljon, Vladimír Kryštof, Lucie Brulíková   +8 more
wiley   +1 more source

Microfluidics-based approaches to the isolation of African trypanosomes [PDF]

, 2017
African trypanosomes are responsible for significant levels of disease in both humans and animals. The protozoan parasites are free-living flagellates, usually transmitted by arthropod vectors, including the tsetse fly. In the mammalian host they live in
Barrett, Michael P., Beech, Jason P., Cooper, Jonathan M., Hochstetter, Axel, Holm, Stefan H., Regnault, Clément, Tegenfeldt, Jonas O.   +6 more
core   +3 more sources

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source