Results 31 to 40 of about 5,177 (179)

Lipids shed into the culture medium by trypomastigotes of Trypanosoma cruzi [PDF]

Memórias do Instituto Oswaldo Cruz, 2000
Trypomastigote forms of Trypanosoma cruzi were metabolically labeled with [14C]-ethanolamine and [3H]-palmitic acid. Lipids shed to the culture medium were analyzed and compared with the parasite components. Phosphatidylcholine and lysophosphatidylcholine accounted for 53% of the total incorporated precursor. Interestingly, phosphatidylethanolamine and
Rosalia Agusti, Alicia S. Couto, Maria Júlia Manso Alves, Walter Colli, Rosa M. de Lederkremer   +4 more
openaire   +4 more sources

Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection. [PDF]

PLoS Pathogens, 2017
Trypanosoma cruzi, the protozoan that causes Chagas disease, has a complex life cycle involving several morphologically and biochemically distinct stages that establish intricate interactions with various insect and mammalian hosts.
A Trey Belew, Caroline Junqueira, Gabriela F Rodrigues-Luiz, Bruna M Valente, Antonio Edson R Oliveira, Rafael B Polidoro, Luciana W Zuccherato, Daniella C Bartholomeu, Sergio Schenkman, Ricardo T Gazzinelli, Barbara A Burleigh, Najib M El-Sayed, Santuza M R Teixeira   +12 more
doaj   +1 more source

Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives

Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.
1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman, Janine Aucamp, Helena D. Janse van Rensburg, Christina Kannigadu, Rotondwa Mphephu, Andrew J. Swarts, Keisuke Suganuma, David D. N'Da   +7 more
wiley   +1 more source

Hybrids of Cinchona Alkaloids and Bile Acids as Antiparasitic Agents Against Trypanosoma cruzi

Molecules, 2019
The current chemotherapy of Chagas disease needs to be urgently improved. With this aim, a series of 16 hybrids of Cinchona alkaloids and bile acids were prepared by functionalization at position C-2 of the quinoline nucleus by a radical attack of a ...
Daniel Musikant, Aurélie Leverrier, Diana Bernal, Gabriel Ferri, Jorge A. Palermo, Martin M. Edreira   +5 more
doaj   +1 more source

Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical Candidates

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Caroline Rodrigues Chaves dos Reis, Hellen Valério Chaves Moura de Souza, Lidia Corrêa Parra, Guilber Valério Chaves Moura de Souza, Bruna Costa Zorzanelli, Nubia Boechat, Lucas Villas Bôas Hoelz, Tácio Vinício Amorim Fernandes   +7 more
wiley   +1 more source

Methylene blue vital staining for Trypanosoma cruzi trypomastigotes and epimastigotes [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 2006
The morphological identification of Trypanosoma cruzi is currently considered to have a high specificity, but its sensitivity, which depends on the volume of the sample examined, is rather low. Trypanosome developmental stages suspended in blood, reduviid feces, and culture media are routinely searched for by means of fresh film examination (about 2 µL)
Ferreira, Cláudio S., Bezerra, Rita C., Pinheiro, Ariadne A.   +2 more
openaire   +3 more sources

Parameters affecting cellular invasion and escape from the parasitophorous vacuole by different infective forms of Trypanosoma cruzi

Memorias do Instituto Oswaldo Cruz, 2003
In this study we have examined certain aspects of the process of cell invasion and parasitophorous vacuole escape by metacyclic trypomastigotes and extracellular amastigote forms of Trypanosoma cruzi (G strain). Using Vero (and HeLa) cells as targets, we
RB Stecconi-Silva, WK Andreoli, RA Mortara   +2 more
doaj   +1 more source

Insight into the Exoproteome of the Tissue-Derived Trypomastigote form of Trypanosoma cruzi [PDF]

Frontiers in Chemistry, 2016
The protozoan parasite Trypanosoma cruzi causes Chagas disease, one of the major neglected infectious diseases. It has the potential to infect any nucleated mammalian cell. The secreted/excreted protein repertoire released by T. cruzi trypomastigotes is crucial in host-pathogen interactions.
Queiroz, Rayner Myr Lauterjung, Ricart, Carlos André Ornelas, Machado, Mara Olimpia, Bastos, Izabela Marques Dourado, Santana, Jaime Martins de, Sousa, Marcelo Valle de, Roepstorf, Peter, Charneau, Sébastien   +7 more
openaire   +6 more sources

Features of host cell invasion by different infective forms of Trypanosoma cruzi [PDF]

Memorias do Instituto Oswaldo Cruz, 1999
Through its life cycle from the insect vector to mammalian hosts Trypanosoma cruzi has developed clever strategies to reach the intracellular milieu where it grows sheltered from the hosts' immune system.
Renato A Mortara, Daniela O Procópio, Helena C Barros, Newton V Verbisck, Walter K Andreoli, Ricardo BS Silva, Solange da Silva   +6 more
doaj   +1 more source

Rhenium Complexes as Antimicrobial Agents

Helvetica Chimica Acta, Volume 109, Issue 5, May 2026.
Rhenium complexes are stepping into the fight against superbugs. Our new review explores how these metallic complexes could inspire the next generation of antimicrobial therapies. ABSTRACT The escalating crisis of antimicrobial resistance (AMR) necessitates the exploration of unconventional therapeutic scaffolds.
Fabio Zobi, Gozde Demirci, Marija Rasic
wiley   +1 more source