Resistance of mice immunized with killed culture trypomastigotes against infection by insect-derived trypomastigotes of Trypanosoma cruzi [PDF]
Revista do Instituto de Medicina Tropical de São Paulo, 1984 Mice immunized with heat or merthiolate-killed culture trypomastigotes of the non-virulent G strain were resistant to the challenge by insect-derived trypomastigotes of the CL strain of Trypanosoma cruzi.
N. Yoshida +3 more
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Production of amastigotes from metacyclic trypomastigotes of Trypanosoma cruzi [PDF]
Memorias do Instituto Oswaldo Cruz, 2002 Attempts to recreate all the developmental stages of Trypanosoma cruzi in vitro have thus far been met with partial success. It is possible, for instance, to produce trypomastigotes in tissue culture and to obtain metacyclic trypomastigotes in axenic ...
Víctor T Contreras +6 more
doaj +4 more sources
PathogensThe protozoan parasite Trypanosoma cruzi is the causative agent of Chagas disease, also called American trypanosomiasis. This neglected tropical disease affects millions of individuals across the Americas. To complete its life cycle, T. cruzi parasitizes
Ramiro Tomasina +4 more
doaj +3 more sources
Exploring 6-Hydroxy-3-Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi. [PDF]
ChemMedChemNew therapies are urgently needed for Chagas disease, and screening of 6‐hydroxy‐3‐aryl/heteroarylcoumarin derivatives identified highly selective compounds with potent activity against T. cruzi. In particular, derivative 1f showed submicromolar trypomastigote potency, dual‐stage activity, and inhibition of amastigote‐to‐trypomastigote differentiation,
Pereira CN +7 more
europepmc +2 more sources
Glycosomal Phosphoenolpyruvate Carboxykinase CRISPR/Cas9-Deletion and Its Role in Trypanosoma cruzi Metacyclogenesis and Infectivity in Mammalian Host. [PDF]
FASEB JEffects of PEPCK deficiency in Trypanosoma cruzi bioenergetics and life stages. ABSTRACT Trypanosoma cruzi, the causative agent of Chagas disease, possesses glycosomes—unique organelles that house key metabolic enzymes, several of which are promising therapeutic targets.
Vieira CSD +8 more
europepmc +2 more sources
Trypanocidal Effects of Polyprenylated Benzophenone Enriched Brazilian Red Propolis Extract and Its Isolated Constituent. [PDF]
Chem BiodiversIn vitro trypanocidal activity of a polyprenylated benzophenone‐enriched Brazilian red propolis extract (SEBz) and its major constituents, guttiferone E/xanthochymol (GUT/XAN) and oblongifolin B (OBL), exhibit in vitro trypanocidal activity against Trypanosoma cruzi, inducing ultrastructural damage with moderate cytotoxicity and no significant ...
Oliveira ND +9 more
europepmc +2 more sources
Dynamics of Mammalian Cell Infection by Trypanosoma cruzi trypomastigotes [PDF]
Frontiers in Microbiology, 2020 In a recent work we demonstrated that Trypanosoma cruzi trypomastigotes change their motility patterns in the presence of mammalian cells, that the extent of the changes depends on the cell line, and that this extent is positively correlated with the efficiency with which parasites invade the different cell lines.
Jorge A. Arias-del-Angel +2 more
openaire +3 more sources
Major surface immunogens of Trypanosoma cruzi trypomastigotes [PDF]
Memorias do Instituto Oswaldo Cruz, 1988 Ali Ouaissi +4 more
doaj +4 more sources
Chagas Disease and Breast-feeding
Emerging Infectious Diseases, 2013 Chagas disease (infection by the protozoan Trypanosoma cruzi) is a major parasitic disease of the Americas and one of the main neglected tropical diseases. Although various routes of transmission are recognized, the risk for transmission of the infection
Francesca F. Norman +1 more
doaj +1 more source
A Novel Method for Inducing Amastigote-To-Trypomastigote Transformation In Vitro in Trypanosoma cruzi Reveals the Importance of Inositol 1,4,5-Trisphosphate Receptor. [PDF]
PLoS ONE, 2015 Trypanosoma cruzi is a parasitic protist that causes Chagas disease, which is prevalent in Latin America. Because of the unavailability of an effective drug or vaccine, and because about 8 million people are infected with the parasite worldwide, the ...
Muneaki Hashimoto +4 more
doaj +1 more source