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The role of serum tryptase in COVID-19 pathogenesis and its value as a prognostic marker: a single-center prospective cohort study [PDF]
Acta Biochimica PolonicaBackgroundDysregulated inflammation is central to COVID-19 pathogenesis. Mast cells (MCs) and their protease tryptase are implicated in tissue injury and vascular dysfunction, but the prognostic value of circulating tryptase in COVID-19 remains uncertain.
Alan Majeranowski +8 more
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Mast cell tryptase and asthma [PDF]
Mediators of Inflammation, 1997 Recent physiological and pharmacological studies have indicated the potential importance of tryptase, the major protein component in mast cells, in inflammatory diseases (especially asthma).
M-Q. Zhang, H. Timmerman
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Tryptase genetics and anaphylaxis [PDF]
Journal of Allergy and Clinical Immunology, 2006 Tryptases secreted by tissue mast cells and basophils can enter the bloodstream. In human subjects tryptases are encoded by several genes and alleles, including alpha, beta, gamma, and delta. Common variations include complete absence of alpha genes.
George H Caughey
exaly +3 more sources
Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells [PDF]
Cell Death DiscoveryMast cells accumulate in breast cancer, but there is only limited knowledge of how they impact on breast cancer growth. Here we show that tryptase, a major compound stored in mast cell secretory granules, has profound effects on breast cancer cell ...
Filip Pano +6 more
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Tryptase and tumor angiogenesis
Frontiers in OncologyTryptases represent the most abundant constituent of human mast cells, involved in extracellular matrix degradation, contributing to wound healing and metastasis. Moreover, most recently, it has been demonstrated that tryptase is angiogenic both in vitro
Domenico Ribatti
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Mast Cell Tryptase Potentiates Neutrophil Extracellular Trap Formation
Journal of Innate Immunity, 2021 Previous research has indicated an intimate functional communication between mast cells (MCs) and neutrophils during inflammatory conditions, but the nature of such communication is not fully understood.
Gunnar Pejler +6 more
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Circulating tryptase as a marker for subclinical atherosclerosis in obese subjects. [PDF]
PLoS ONE, 2014 INTRODUCTION: Mast cells participate in atherogenesis by releasing cytokines to induce vascular cell protease expression. Tryptase is expressed highly in human atherosclerotic lesions and the inhibition of tryptase activity hampers its capacity to ...
María Moreno +6 more
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Tryptase Regulates the Epigenetic Modification of Core Histones in Mast Cell Leukemia Cells
Frontiers in Immunology, 2021 Mast cells are immune cells that store large amounts of mast cell-restricted proteases in their secretory granules, including tryptase, chymase and carboxypeptidase A3.
Sultan Alanazi +2 more
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A simple, sensitive and safe method to determine the human α/β-tryptase genotype. [PDF]
PLoS ONE, 2014 The human tryptase locus on chromosome 16 contains one gene encoding only β-tryptase and another encoding either β-tryptase or the homologous α-tryptase, providing α:β gene ratios of 0:4, 1:3 or 2:2 in the diploid genome, these genotypes being of ...
Quang Trong Le +3 more
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Clinical and Translational Science, 2023 Tryptase, a protease implicated in asthma pathology, is secreted from mast cells upon activation during an inflammatory allergic response. MTPS9579A is a novel monoclonal antibody that inhibits tryptase activity by irreversibly dissociating the active ...
Sharon M. Rymut +9 more
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