Results 11 to 20 of about 14,721 (198)

Tryptase promotes atherosclerotic plaque haemorrhage in ApoE-/- mice. [PDF]

PLoS ONE, 2013
Tryptase, the most abundant mast cell (MC) granule protein, plays an important role in atherosclerosis plaque development. To test the hypothesis that tryptase participates directly in atherosclerosis plaque haemorrhage, the gene sequence and siRNA for ...
Xiuling Zhi, Chen Xu, Hao Zhang, Dai Tian, Xiaobo Li, Yanxia Ning, Lianhua Yin   +6 more
doaj   +1 more source

Tryptase activates enteric glial cells followed by affecting neuronal properties possibly via the stimuli-associated mediators

Journal of Pharmacological Sciences, 2023
Objectives: Mast cell-derived tryptase causes neuronal elongation/sensitization leading to visceral hypersensitivity. However, effects of tryptase on enteric glial cells (EGCs) and subsequent interaction between EGCs and neurons remain unknown.
Kazunari Tominaga, Yoshiko Fujikawa
doaj   +1 more source

Correlation between serum tryptase, mast cells positive to tryptase and microvascular density in colo-rectal cancer patients: possible biological-clinical significance. [PDF]

PLoS ONE, 2014
BACKGROUND: Tryptase is a serin protease stored and released from mast cells (MCs) that plays a role in tumour angiogenesis. In this study we aimed to evaluate serum tryptase levels in colo-rectal cancer (CRC) patients before (STLBS) and after (STLAS ...
Michele Ammendola, Rosario Sacco, Giuseppe Sammarco, Giuseppe Donato, Severino Montemurro, Eustachio Ruggieri, Rosa Patruno, Ilaria Marech, Marica Cariello, Angelo Vacca, Cosmo Damiano Gadaleta, Girolamo Ranieri   +11 more
doaj   +1 more source

Mast Cell Tryptase Stimulates DLD-1 Carcinoma Through Prostaglandin- and MAP Kinase-Dependent Manners

Journal of Pharmacological Sciences, 2005
We found that striptease-positive mast cells were abundant in the invasive front of human colon adenocarcinoma by examining 30 cases. Because tryptase has been suggested to be the agonist proteinase for protease-activated receptor-2 (PAR-2), we ...
Masanori Yoshii, Atsushi Jikuhara, Shuji Mori, Hiromi Iwagaki, Hideo K. Takahashi, Masahiro Nishibori, Noriaki Tanaka   +6 more
doaj   +1 more source

Altered immunohistochemical expression of mast cell tryptase and chymase in the pathogenesis of oral submucous fibrosis and malignant transformation of the overlying epithelium. [PDF]

PLoS ONE, 2014
Mast cells (MCs) expressing serine proteases; tryptase and chymase, are associated with fibrosis in various diseases. However, little is known about their involvement in oral submucous fibrosis (OSF).
Archana Yadav, Rajiv S Desai, Bansari A Bhuta, Jatinder S Singh, Reema Mehta, Akash P Nehete   +5 more
doaj   +1 more source

Mast cell tryptase enhances wound healing by promoting migration in human bronchial epithelial cells

Cell Adhesion & Migration, 2021
Epithelial damage and increase of intraepithelial mast cells (MC) are characteristics of asthma. The role of MC mediator tryptase and the protease-activated receptor-2 (PAR2) on epithelial wound healing is not fully investigated. Stimulation of bronchial
Sofia Mogren, Frida Berlin, Sangeetha Ramu, Asger Sverrild, Celeste Porsbjerg, Lena Uller, Cecilia K Andersson   +6 more
doaj   +1 more source

Diagnostic Significance of Tryptase for Suspected Mast Cell Disorders

Diagnostics, 2023
Tryptase has proven to be a very useful and specific marker to demonstrate mast cell activation and degranulation when an acute (i.e., within 4 h after the event) and baseline value (i.e., at least 24 h after the event) are compared and meet the ...
Michiel Beyens, Alessandro Toscano, Didier Ebo, Theo Gülen, Vito Sabato   +4 more
doaj   +1 more source

Activation of Protease-Activated Receptor 2-Mediated Signaling by Mast Cell Tryptase Modulates Cytokine Production in Primary Cultured Astrocytes

Mediators of Inflammation, 2013
Protease-activated receptor 2 (PAR-2), which is abundantly expressed in astrocytes, is known to play major roles in brain inflammation. However, the influence of the natural agonist of PAR-2, tryptase, on proinflammatory mediator releasedfrom astrocytes ...
Xiaoning Zeng, Shu Zhang, Luwei Xu, Haiwei Yang, Shaoheng He   +4 more
doaj   +1 more source

Mast Cell Tryptase Promotes Airway Remodeling by Inducing Anti-Apoptotic and Cell Growth Properties in Human Alveolar and Bronchial Epithelial Cells

Cells, 2023
Bronchial and alveolar remodeling and impaired epithelial function are characteristics of chronic respiratory diseases. In these patients, an increased number of mast cells (MCs) positive for serine proteases, tryptase and chymase, infiltrate the ...
Frida Berlin, Sofia Mogren, Camilla Ly, Sangeetha Ramu, Morten Hvidtfeldt, Lena Uller, Celeste Porsbjerg, Cecilia K. Andersson   +7 more
doaj   +1 more source

Nafamostat Mesilate Is an Extremely Potent Inhibitor of Human Tryptase

Journal of Pharmacological Sciences, 2003
Previously, nafamostat mesilate was found to be a potent inhibitor of human tryptase. In present study, we performed a kinetic study to determine its Ki value for tryptase and compared it with that of gabexate mesilate.
Shuji Mori, Yoshinori Itoh, Ryoko Shinohata, Toshiaki Sendo, Ryozo Oishi, Masahiro Nishibori   +5 more
doaj   +1 more source