Results 21 to 30 of about 14,721 (198)

Mast cells and tryptase. Modern aspects

Медицинская иммунология, 2021
The present review considers the role of mast cells (MC) and tryptase levels in various pathological conditions in children and adults. The main causes of hypertryptasemia are presented, as well as a list of the most important stimuli that can cause ...
D. Sh. Macharadze
doaj   +1 more source

Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2

Journal of Neuroinflammation, 2018
Background Mast cells (MCs), the ‘first responders’ in brain injury, are able to disrupt the blood–brain barrier (BBB), but the underlying mechanism is not well understood. Tryptase is the most abundant MC secretory product. Protease-activated receptor 2
Qin Zhou, Yi-wei Wang, Peng-fei Ni, Yi-nan Chen, Hong-quan Dong, Yan-ning Qian   +5 more
doaj   +1 more source

Direct effects of mast cell proteases, tryptase and chymase, on bronchial epithelial integrity proteins and anti-viral responses

BMC Immunology, 2021
Background Mast cells (MCs) are known to contribute to both acute and chronic inflammation. Bronchial epithelial cells are the first line of defence against pathogens and a deficient anti-viral response has been suggested to play a role in the ...
Sangeetha Ramu, Hamid Akbarshahi, Sofia Mogren, Frida Berlin, Samuel Cerps, Mandy Menzel, Morten Hvidtfeldt, Celeste Porsbjerg, Lena Uller, Cecilia K. Andersson   +9 more
doaj   +1 more source

Changes in tryptase levels during cardiac surgery in patients at low risk for allergic reactions

Medičnì Perspektivi, 2022
Tryptase test can be used as a clinical marker of mast cell activation. The present study is was aimed to identify variations in serum tryptase levels and their possible relationships with allergic reactions to protamine in low-risk patients undergoing ...
Menekse Oksar, Hasibe G. Baytan, Selim Turhanoglu, Tayfun Aybek, Nazife Y. Ardicoglu, Oguzhan Ozcan   +5 more
doaj   +1 more source

Isolation of Allosteric Tryptase Inhibitor from Methanol Extract of Rhubarb and Enhancement of Its Tryptase Inhibitory Activity by Compounds That Were Screened by In Silico Screening

Molecules
Tryptase, which is abundant in human mast cells and is involved in allergic inflammations such as asthma, is a serine protease. We isolated a tryptase inhibitor, procyanidin B8 3,3′-di-O-gallate (PB8GG’), a tannin, from the methanol extract of rhubarb ...
Hidetoshi Fujii, Moeno Ito, Kentaro Nishioka, Katsutoshi Nishino, Takanao Otsuka, Kazuhiro Irie, Takashi Tanaka, Masaya Nagao   +7 more
doaj   +1 more source

Influence of Perinatal Factors on Blood Tryptase and Fecal Calprotectin Levels in Newborns

Children, 2023
Background: Blood tryptase and fecal calprotectin levels may serve as biomarkers of necrotizing enterocolitis. However, their interpretation may be hindered by the little-known effects of perinatal factors.
Justine Paysal, Charlotte Oris, Ugo Troin, Pierre-Nicolas Limeri, Jeanne Allard, Marie Tadrent, Bruno Pereira, Etienne Merlin, Emmanuelle Rochette, Bertrand Evrard, Julie Durif, Vincent Sapin, Maguelonne Pons   +12 more
doaj   +1 more source

Tryptase in type I hypersensitivity

Annals of Allergy, Asthma & Immunology, 2023
Tryptase is currently the main mast cell biomarker available in medical practice. Tryptase determination is a quantitative test performed in serum or plasma for the diagnosis, stratification, and follow-up of mast cell-related conditions. The continuous secretion of monomeric α and β protryptases forms the baseline tryptase level. Transient, activation-
Michel, Moïse, Klingebiel, Caroline, Vitte, Joana   +2 more
openaire   +2 more sources

CNC–PNIPAM Drug Delivery System Improves Endometrial Receptivity via Natural Killer Cell Immune Tolerance in Endometriosis

Advanced NanoBiomed Research, EarlyView.
An injectable CNC–PNIPAM hydrogel is developed for intrauterine co‐delivery of levonorgestrel and botropase. This platform reprograms uterine natural killer cells toward an immune–tolerant phenotype and enhances endometrial receptivity marker expression. The results demonstrate a promising strategy to counteract endometriosis–associated infertility and
Zhou Liang, Yingjie Wang, Chenyu Bai, Pengfei Li, Xin He, Meng Ma, Xiaoying Luo, Yi Song, Yao Li, Yun Wang   +9 more
wiley   +1 more source

A targeted amplicon next-generation sequencing assay for tryptase genotyping to support personalized therapy in mast cell-related disorders.

PLoS ONE
Tryptase, the most abundant mast cell granule protein, is elevated in severe asthma patients independent of type 2 inflammation status. Higher active β tryptase allele counts are associated with higher levels of peripheral tryptase and lower clinical ...
Olga Li, Jason A Hackney, David F Choy, Diana Chang, Rhea Nersesian, Tracy L Staton, Fang Cai, Shadi Toghi Eshghi   +7 more
doaj   +1 more source

Correlation of IL-18 with Tryptase in Atopic Asthma and Induction of Mast Cell Accumulation by IL-18

Mediators of Inflammation, 2016
Interleukin- (IL-) 18 and tryptase were previously reported to relate to asthma, but the correlation between these two potent proinflammatory molecules in asthma and their roles in mast cell accumulation remain uninvestigated.
Junling Wang, Huiyun Zhang, Wenjiao Zheng, Hua Xie, Hongling Yan, Xiaoping Lin, Shaoheng He   +6 more
doaj   +1 more source